Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF7
HR+
Luminal
 Ixabepilone
TUBB
TUBB
7492.095
uM
inf
inf
 0.9180 0.9180 0.0000 0.0139
0.0229
 1.0194
MCF7
HR+
Luminal
 Ixabepilone
TUBB
TUBB
7493.095
uM
0.00008
0.02291
 -0.9964 -1.0000 0.1944 1.0719
0.7483
 1.0092
MCF7
HR+
Luminal
 JNK-IN-5A
JNK
JNK
10997.144
uM
inf
inf
 0.9861 0.9861 0.0000 0.0703
0.2540
 1.2750
MCF7
HR+
Luminal
 L-779450
BRAF
MAPK
10997.149
uM
204.30170
999.98210
 0.7861 -0.8139 0.6084 0.0188
0.7292
 1.2614
MCF7
HR+
Luminal
 Lapatinib
EGFR/HER2
ErbB
7492.098
uM
inf
inf
 0.9404 0.9404 0.0000 0.0256
0.1822
 1.5701
MCF7
HR+
Luminal
 Lapatinib
EGFR/HER2
ErbB
7493.098
uM
inf
inf
 0.7411 0.7411 0.0000 0.0990
0.4417
 1.0051
MCF7
HR+
Luminal
 LBH589
HDAC
HDAC
10997.154
uM
0.07643
0.15390
 -0.9419 -0.9155 1.4869 0.7846
0.9989
 1.0978
MCF7
HR+
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10997.154
uM
1.4390
2.13190
 -0.9374 -0.9514 2.7114 0.4198
0.9939
 1.0978
MCF7
HR+
Luminal
 Mebendazole
12657.174
uM
1.06950
0.35146
 0.2654 0.3736 1.2360 0.2660
0.9367
 1.0776
MCF7
HR+
Luminal
 Methotrexate
DHFR
Metabolism
7493.085
uM
0.02639
0.02219
 0.1493 0.1882 2.7232 0.6234
0.9274
 1.4204
MCF7
HR+
Luminal
 Methotrexate
DHFR
Metabolism
7492.084
uM
0.17780
0.02952
 0.4481 0.4625 1.4432 0.3930
0.9685
 1.4850
MCF7
HR+
Luminal
 Methylglyoxal
13555.184
uM
538.49650
1000.00000
 -0.9769 -0.7313 1.4559 0.4634
0.9479
 1.0647
MCF7
HR+
Luminal
 MG-132
Proteasome
Proteasome
10997.145
uM
0.35937
0.76083
 -0.9042 -0.9192 1.3908 0.6945
0.9936
 1.3945
MCF7
HR+
Luminal
 MG-132
Proteasome
Proteasome
10997.145
uM
0.35937
0.76083
 -0.9042 -0.9192 1.3908 0.6945
0.9936
 1.3945
MCF7
HR+
Luminal
 MG-132
Proteasome
Proteasome
14640.189
uM
0.44980
1.26680
 -0.8133 -0.8930 0.9895 0.5950
0.9941
 1.5721
MCF7
HR+
Luminal
 MG-132
Proteasome
Proteasome
14640.189
uM
0.44980
1.26680
 -0.8133 -0.8930 0.9895 0.5950
0.9941
 1.5721
MCF7
HR+
Luminal
 Pevonedistat
NAE1
NAE1
10997.135
uM
0.06016
0.22250
 -0.8261 -0.8629 0.7667 0.8392
0.9921
 0.6582
MCF7
HR+
Luminal
 Nelfinavir
12657.174
uM
13.85990
23.80460
 -0.3289 -1.0000 2.0312 0.1354
0.9841
 1.0776
MCF7
HR+
Luminal
 Nilotinib
ABL
nRTK
10997.145
uM
inf
inf
 1.0396 1.0396 0.0000 0.0666
0.0029
 1.3945
MCF7
HR+
Luminal
 NSC 663284
CDC25
CDC
10997.152
uM
3.61560
6.26870
 -0.8983 -0.9350 1.9159 0.5251
0.9971
 1.3917
MCF7
HR+
Luminal
 NU6102
CDK1/2
CDK
10997.147
uM
29.87020
39.98180
 -0.4339 -0.7293 3.0853 0.1317
0.9846
 1.3792
MCF7
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7492.066
uM
7.69320
45.28360
 -0.1263 -1.0000 0.6198 0.2422
0.9348
 1.6656
MCF7
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7493.066
uM
5.23030
20.23320
 -0.4732 -1.0000 0.8121 0.2379
0.9949
 1.3293
MCF7
HR+
Luminal
 Olomoucine II
CDK1
CDK
10997.147
uM
5.72860
6.85080
 -0.6358 -0.6337 4.5758 0.3828
0.9944
 1.3792
MCF7
HR+
Luminal
 Omipalisib
PI3K
PI3K
7493.086
uM
0.00717
0.01731
 -0.7558 -0.7434 1.0346 1.0210
0.9993
 0.8986