Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF7
HR+
Luminal
 ZM-447439
AURK
AURK
10997.15
uM
inf
inf
 0.7198 0.7198 0.0000 0.1640
0.5121
 1.4218
MDA-MB-134-VI
HR+
Luminal
 (Z)-4-Hydroxytamoxifen
ESR1
7876.016
uM
inf
0.05607
 0.5547 0.5413 0.4800 0.2794
0.8724
 1.0580
MDA-MB-134-VI
HR+
Luminal
 17-AAG
HSP90
HSP90
10077.037
uM
0.02614
0.04840
 -0.9963 -0.8377 1.5975 1.0570
0.9910
 0.4524
MDA-MB-134-VI
HR+
Luminal
 17-AAG
HSP90
HSP90
7876.04
uM
0.04624
0.06744
 -0.7726 -0.6991 2.3168 0.9485
0.9976
 1.0852
MDA-MB-134-VI
HR+
Luminal
 17-AAG
HSP90
HSP90
7877.05
uM
0.03175
0.04491
 -0.9920 -0.9506 3.0706 1.1407
0.9988
 0.5502
MDA-MB-134-VI
HR+
Luminal
 2-deoxyglucose
12662.177
uM
inf
inf
 0.9676 0.9676 0.0000 0.0405
0.0000
 1.7065
MDA-MB-134-VI
HR+
Luminal
 5-DFUR
TYMS
TYMS
10998.143
uM
313.21770
1000.00000
 -0.2431 -0.5980 0.6776 0.3270
0.8588
 0.5976
MDA-MB-134-VI
HR+
Luminal
 5-DFUR
TYMS
TYMS
12206.143
uM
679.57740
1000.00000
 0.0333 -0.1914 0.8391 0.1970
0.9824
 1.0676
MDA-MB-134-VI
HR+
Luminal
 5-FU
TYMS
TYMS
7876.017
uM
24.33680
434.4740
 -0.7133 -1.0000 0.3812 0.6725
0.9013
 0.6706
MDA-MB-134-VI
HR+
Luminal
 5-FU
TYMS
TYMS
7877.017
uM
1133.96240
1000.00000
 0.0563 0.0528 0.8868 0.1924
0.9551
 0.6955
MDA-MB-134-VI
HR+
Luminal
 Afatinib
EGFR/HER2
ErbB
12206.158
uM
3.33710
7.16120
 -0.9506 -1.0000 1.4388 0.4069
0.9869
 1.1431
MDA-MB-134-VI
HR+
Luminal
 AG1024
IGF1R
RTK
10419.066
uM
inf
3.79940
 0.5617 0.5531 1.9221 0.0995
0.8921
 0.6963
MDA-MB-134-VI
HR+
Luminal
 AG1024
IGF1R
RTK
7494.066
uM
13.27460
49.00060
 0.1544 -0.9999 0.8412 0.1534
0.9130
 0.9416
MDA-MB-134-VI
HR+
Luminal
 AG1478
EGFR
ErbB
7876.016
uM
1104.7820
62.16970
 0.5982 0.4885 1.3113 0.0533
0.9403
 1.0580
MDA-MB-134-VI
HR+
Luminal
 AS-252424
PI3K
PI3K
12206.158
uM
inf
3.00130
 0.4194 0.6082 5.0000 0.1235
0.6592
 1.1431
MDA-MB-134-VI
HR+
Luminal
 AS-252424
PI3K
PI3K
10998.153
uM
36.22160
639.31790
 0.4741 -1.0000 0.3827 0.1367
0.7941
 0.7434
MDA-MB-134-VI
HR+
Luminal
 AS-252424
PI3K
PI3K
10519.141
uM
11.26360
7.80090
 0.2621 0.2473 1.8579 0.1286
0.9873
 1.0417
MDA-MB-134-VI
HR+
Luminal
 Baicalein
Lipoxygenase
Metabolism
10998.072
uM
128.2460
157.64570
 -0.0879 -0.9033 4.9999 0.1646
0.8691
 0.8910
MDA-MB-134-VI
HR+
Luminal
 Baicalein
Lipoxygenase
Metabolism
10419.072
uM
74.75730
130.77090
 -0.2362 -0.9999 1.9645 0.1775
0.9253
 0.6039
MDA-MB-134-VI
HR+
Luminal
 Baicalein
Lipoxygenase
Metabolism
10519.072
uM
107.35720
104.39160
 0.2099 0.0445 3.3261 0.0595
0.9671
 0.9861
MDA-MB-134-VI
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7494.074
uM
0.04408
0.06633
 -0.9985 -1.0000 2.6881 1.2339
0.9978
 0.6767
MDA-MB-134-VI
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7494.074
uM
0.04408
0.06633
 -0.9985 -1.0000 2.6881 1.2339
0.9978
 0.6767
MDA-MB-134-VI
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14837.203
uM
0.00955
0.01392
 -0.9078 -0.9193 2.7681 1.2790
0.9995
 1.5334
MDA-MB-134-VI
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14837.203
uM
0.00955
0.01392
 -0.9078 -0.9193 2.7681 1.2790
0.9995
 1.5334
MDA-MB-134-VI
HR+
Luminal
 Bosutinib
Src
nRTK
10998.145
uM
inf
inf
 0.7397 0.7397 0.0000 0.2181
0.0000
 0.9403