Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 12206.145 | uM | 10.59210 | 8.23350 | 0.2171 | 0.3581 | 4.9998 | 0.1235 | 0.9077 | 0.8709 | |
| MDA-MB-134-VI | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12662.177 | uM | 0.32133 | 0.39543 | -0.8870 | -0.8663 | 4.8445 | 0.6389 | 0.9978 | 1.7065 | |
| MDA-MB-134-VI | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | 248.53190 | 343.89760 | -0.9993 | -1.0000 | 3.3827 | 0.2219 | 0.9702 | 0.3095 | |
| MDA-MB-134-VI | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10077.119 | uM | 199.35420 | 247.72370 | -0.9810 | -0.9814 | 5.0000 | 0.2482 | 0.9964 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Celecoxib | COX2 | COX | 10519.136 | uM | inf | inf | 0.9386 | 0.9386 | 0.0000 | 0.0506 | 0.0000 | 1.1406 | |
| MDA-MB-134-VI | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7877.042 | uM | inf | inf | 0.9001 | 0.9001 | 0.0000 | 0.0283 | 0.1356 | 0.3414 | |
| MDA-MB-134-VI | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7876.042 | uM | inf | inf | 0.9178 | 0.9178 | 0.0000 | -0.0251 | 0.2224 | 1.0958 | |
| MDA-MB-134-VI | HR+ | Luminal | Cetuximab | EGFR | ErbB | 10077.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3999 | |
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 10077.026 | uM | 859.70570 | 1000.00000 | -0.8312 | -0.5647 | 5.0000 | 0.1049 | 0.8794 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 10519.14 | uM | inf | 8.4880 | 0.8839 | 0.8826 | 5.0000 | 0.0185 | 0.7338 | 1.0269 | |
| MDA-MB-134-VI | HR+ | Luminal | Chloroquine | 12662.177 | uM | 15.3560 | 23.89390 | -0.8553 | -1.0000 | 2.4849 | 0.1883 | 0.9958 | 1.7065 | |||
| MDA-MB-134-VI | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10077.049 | uM | inf | inf | 0.6528 | 0.6528 | 0.0000 | 0.0188 | 0.5081 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | inf | inf | -0.7752 | -0.7752 | 0.0000 | 0.3146 | 0.5744 | 0.3095 | |
| MDA-MB-134-VI | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7876.017 | uM | 1.23770 | 8.64030 | -0.9480 | -1.0000 | 0.5654 | 0.6496 | 0.6203 | 0.6706 | |
| MDA-MB-134-VI | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7877.017 | uM | 39.9950 | 44.33310 | -0.1249 | -0.1418 | 2.4251 | 0.1349 | 0.9935 | 0.6955 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 7877.007 | uM | 0.61397 | 0.87310 | -0.3750 | -0.3060 | 1.3561 | 0.4489 | 0.9724 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 7876.007 | uM | 2.66370 | 1.61440 | 0.2435 | 0.2984 | 1.8143 | 0.1778 | 0.9794 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | CPT-11 | TOP1 | TOP | 10077.121 | uM | 17.80130 | 19.49840 | -0.2875 | -0.2883 | 4.9995 | 0.1008 | 0.9908 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 10998.155 | uM | inf | inf | 0.3974 | 0.3974 | 0.0000 | 0.2489 | 0.2687 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 12206.155 | uM | inf | inf | 0.6542 | 0.6542 | 0.0000 | 0.2347 | 0.3577 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12662.176 | uM | inf | inf | 0.9145 | 0.9145 | 0.0000 | 0.0531 | -0.0833 | 1.8146 | |
| MDA-MB-134-VI | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 12662.174 | uM | 1.62640 | 12.01690 | -0.8536 | -1.0000 | 0.5493 | 0.3683 | 0.7755 | 1.6130 | |
| MDA-MB-134-VI | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10265.002 | uM | 0.00770 | 0.01408 | -0.2837 | -0.2417 | 0.6532 | 0.6461 | 0.8540 | 0.3365 | |
| MDA-MB-134-VI | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10077.002 | uM | 0.03026 | 0.02447 | 0.0081 | 0.2093 | 2.5501 | 0.3494 | 0.9363 | 0.4343 | |
| MDA-MB-134-VI | HR+ | Luminal | Docetaxel | TUBB | TUBB | 7876.002 | uM | 0.00551 | 0.00687 | -0.2072 | -0.2218 | 1.6678 | 0.6908 | 0.9962 | 1.1036 |