Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7877.007 | uM | inf | inf | -0.9909 | -0.9909 | 0.0000 | 0.6097 | 0.4266 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 10077.121 | uM | 1.34490 | 1.83630 | -0.9975 | -0.9923 | 3.5115 | 0.6376 | 0.9882 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7876.007 | uM | 1.06330 | 2.07780 | -0.8892 | -0.8744 | 1.5092 | 0.5300 | 0.9983 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7877.017 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1618 | 0.3038 | 0.6955 | |
| MDA-MB-134-VI | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7876.017 | uM | 0.90344 | 1.11330 | -0.9973 | -0.9208 | 5.0000 | 0.9405 | 0.8510 | 0.6706 | |
| MDA-MB-134-VI | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7494.09 | uM | inf | inf | 0.5852 | 0.5852 | 0.0000 | 0.1382 | 0.2867 | 1.0823 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 7494.074 | uM | 2.0210 | 9.25790 | -0.4413 | -0.6520 | 0.5485 | 0.4865 | 0.9491 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Everolimus | MTOR | MTOR | 12206.164 | uM | 0.04481 | 5.0760 | -0.6044 | -1.0000 | 0.2323 | 0.6218 | 0.8258 | 0.9848 | |
| MDA-MB-134-VI | HR+ | Luminal | Everolimus | MTOR | MTOR | 10998.156 | uM | 0.03087 | 0.03675 | -0.6176 | -0.1754 | 1.7241 | 0.6564 | 0.8948 | 0.5969 | |
| MDA-MB-134-VI | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7494.084 | uM | 0.22848 | 0.40566 | -0.9871 | -0.9935 | 1.9062 | 0.7320 | 0.9661 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10998.149 | uM | inf | inf | 0.8891 | 0.8891 | 0.0000 | 0.0573 | -0.0816 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10519.137 | uM | inf | inf | 0.8748 | 0.8748 | 0.0000 | 0.0872 | -0.0369 | 1.0772 | |
| MDA-MB-134-VI | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12206.161 | uM | inf | inf | 0.6658 | 0.6658 | 0.0000 | 0.0853 | 0.130 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10998.154 | uM | inf | inf | 0.7776 | 0.7776 | 0.0000 | 0.1253 | -0.1381 | 0.7412 | |
| MDA-MB-134-VI | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12206.154 | uM | inf | inf | 0.8646 | 0.8646 | 0.0000 | 0.0941 | 0.0903 | 1.0125 | |
| MDA-MB-134-VI | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10519.142 | uM | inf | inf | 0.6717 | 0.6717 | 0.0000 | 0.1516 | 0.1548 | 0.8963 | |
| MDA-MB-134-VI | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7876.016 | uM | 38.95080 | 42.56820 | 0.7100 | -0.2794 | 4.9982 | 0.0209 | 0.7741 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | Gefitinib | EGFR | ErbB | 10077.049 | uM | 30.07760 | 34.24460 | 0.3223 | -0.4566 | 5.0000 | 0.0293 | 0.8649 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 10077.049 | uM | 0.01974 | 0.03726 | -0.8013 | -0.6827 | 1.3555 | 0.9971 | 0.9821 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 7876.04 | uM | 0.01441 | 0.01851 | -0.6865 | -0.6674 | 3.3908 | 1.1164 | 0.9993 | 1.0852 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 10077.119 | uM | 625.98190 | 1000.00000 | -0.9991 | -0.6749 | 1.8238 | 0.1906 | 0.870 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10998.15 | uM | 1.00540 | 3.50130 | -0.8631 | -1.0000 | 0.8805 | 0.3939 | 0.9837 | 0.8386 | ||
| MDA-MB-134-VI | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12206.16 | uM | 1.22030 | 5.55730 | -0.8227 | -1.0000 | 0.7247 | 0.4363 | 0.9848 | 0.9874 | ||
| MDA-MB-134-VI | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10519.138 | uM | 1.95280 | 4.4310 | -0.7360 | -0.8790 | 1.2382 | 0.3284 | 0.9962 | 1.0592 | ||
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 10077.001 | uM | 3.58350 | 6.40860 | -0.4458 | -0.6001 | 1.3565 | 0.2544 | 0.9488 | 0.5941 |