Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-175-VII
HR+
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
12126.154
uM
0.09697
0.41793
 -0.9278 -0.7819 0.6444 0.7226
0.8237
 0.6012
MDA-MB-175-VII
HR+
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10818.154
uM
0.65803
0.88856
 -0.8282 -0.3921 1.9274 0.5051
0.8253
 0.5056
MDA-MB-175-VII
HR+
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10642.142
uM
0.65586
1.3130
 -0.8282 -0.5327 1.0450 0.5569
0.9052
 0.5006
MDA-MB-175-VII
HR+
Luminal
 Mebendazole
13754.174
uM
0.13250
21.1220
 -0.1183 -1.0000 0.2166 0.5383
0.8916
 0.4290
MDA-MB-175-VII
HR+
Luminal
 Methotrexate
DHFR
Metabolism
7499.084
uM
inf
inf
 0.8028 0.8028 0.0000 0.0973
-0.0768
 0.7991
MDA-MB-175-VII
HR+
Luminal
 Methotrexate
DHFR
Metabolism
7500.084
uM
inf
inf
 1.0314 1.0314 0.0000 0.0284
0.0671
 0.5811
MDA-MB-175-VII
HR+
Luminal
 Methylglyoxal
13676.184
uM
458.37740
1000.00000
 -0.9929 -0.6170 1.0304 0.4458
0.8181
 0.9355
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
14269.189
uM
0.16097
0.19121
 -0.9893 -0.6827 5.0000 0.8112
0.8780
 0.5173
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
14269.189
uM
0.16097
0.19121
 -0.9893 -0.6827 5.0000 0.8112
0.8780
 0.5173
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
10818.145
uM
0.17172
0.25805
 -0.9991 -0.9978 2.6938 0.8999
0.9924
 0.4621
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
10818.145
uM
0.17172
0.25805
 -0.9991 -0.9978 2.6938 0.8999
0.9924
 0.4621
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
12126.145
uM
0.19099
0.26765
 -0.9943 -0.9939 3.2434 0.8985
0.9941
 0.6493
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
12126.145
uM
0.19099
0.26765
 -0.9943 -0.9939 3.2434 0.8985
0.9941
 0.6493
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
10642.145
uM
0.30670
0.38133
 -0.9982 -0.9855 5.0000 0.8413
0.9966
 0.3537
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
10642.145
uM
0.30670
0.38133
 -0.9982 -0.9855 5.0000 0.8413
0.9966
 0.3537
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
14619.189
uM
0.35854
0.51258
 -0.8410 -0.8526 2.7843 0.7257
0.9976
 1.2787
MDA-MB-175-VII
HR+
Luminal
 MG-132
Proteasome
Proteasome
14619.189
uM
0.35854
0.51258
 -0.8410 -0.8526 2.7843 0.7257
0.9976
 1.2787
MDA-MB-175-VII
HR+
Luminal
 Pevonedistat
NAE1
NAE1
12126.135
uM
0.31289
0.42230
 -0.1996 -0.1817 1.0338 0.5180
0.9398
 0.7048
MDA-MB-175-VII
HR+
Luminal
 Pevonedistat
NAE1
NAE1
10642.135
uM
0.12059
0.45704
 -0.8966 -0.9086 0.7774 0.8054
0.950
 0.3509
MDA-MB-175-VII
HR+
Luminal
 Pevonedistat
NAE1
NAE1
10818.148
uM
0.25285
0.38355
 -0.8018 -0.6596 2.0189 0.6696
0.9876
 0.3526
MDA-MB-175-VII
HR+
Luminal
 Nelfinavir
13754.174
uM
6.54890
9.60220
 -0.9753 -1.0000 2.8707 0.3702
0.8599
 0.4290
MDA-MB-175-VII
HR+
Luminal
 Nilotinib
ABL
nRTK
12126.145
uM
inf
inf
 0.8161 0.8161 0.0000 0.1164
0.1697
 0.6493
MDA-MB-175-VII
HR+
Luminal
 Nilotinib
ABL
nRTK
10818.145
uM
inf
0.93047
 0.6960 0.6936 2.0851 0.1584
0.6048
 0.4621
MDA-MB-175-VII
HR+
Luminal
 Nilotinib
ABL
nRTK
10642.145
uM
7.49980
7.54360
 -0.3759 -0.0148 5.0000 0.2756
0.8546
 0.3537
MDA-MB-175-VII
HR+
Luminal
 NSC 663284
CDC25
CDC
10642.14
uM
4.82050
8.19110
 -0.9997 -1.0000 2.0722 0.6033
0.9324
 0.5473