Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9648.002 | uM | 0.00471 | 0.00566 | -0.2165 | -0.2169 | 1.9624 | 0.7100 | 0.9654 | 0.6465 | |
| MDA-MB-361 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 7896.002 | uM | 0.0130 | 0.01389 | -0.0909 | -0.1059 | 2.9224 | 0.5705 | 0.9819 | 1.1441 | |
| MDA-MB-361 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 12989.002 | uM | 0.00679 | 0.00820 | -0.2712 | -0.2397 | 2.0828 | 0.6940 | 0.9982 | 0.6028 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9648.121 | uM | 0.11428 | 0.13646 | -0.9995 | -0.7141 | 5.0000 | 0.8762 | 0.9561 | 0.6537 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7505.078 | uM | 0.35120 | 0.63497 | -0.9764 | -0.6448 | 1.3988 | 0.5949 | 0.9563 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 10095.034 | uM | 0.09494 | 0.16667 | -0.9958 | -0.6518 | 1.4828 | 0.7776 | 0.9615 | 0.7874 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7896.007 | uM | 0.21394 | 0.48965 | -0.9610 | -0.7252 | 1.0825 | 0.6704 | 0.9714 | 1.1203 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7896.043 | uM | 4.09090 | 6.99190 | -0.5297 | -0.5851 | 1.4456 | 0.3427 | 0.9856 | 0.8553 | |
| MDA-MB-361 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7896.017 | uM | 0.25479 | 0.30463 | -0.9995 | -0.7217 | 5.0000 | 0.8046 | 0.9647 | 1.0113 | |
| MDA-MB-361 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 9648.017 | uM | 0.17877 | 0.21867 | -1.0000 | -0.8691 | 5.0000 | 0.9654 | 0.9842 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7505.09 | uM | inf | 7.04310 | 0.5491 | 0.5416 | 5.0000 | 0.1188 | 0.6842 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7506.091 | uM | inf | 11.9710 | 0.5290 | 0.5289 | 5.0000 | 0.0500 | 0.9444 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7507.09 | uM | 70.83440 | 218.58970 | 0.5210 | -0.9999 | 0.9749 | 0.0435 | 0.9824 | 1.0118 | |
| MDA-MB-361 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7508.091 | uM | 33.25310 | 94.15250 | 0.1742 | -1.0000 | 1.0556 | 0.0938 | 0.9879 | 0.6662 | |
| MDA-MB-361 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 7506.074 | uM | 27.26110 | 30.64750 | -0.1136 | -0.1280 | 1.9469 | 0.2574 | 0.9659 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 7507.074 | uM | 11.56640 | 16.89680 | -0.6505 | -0.6690 | 2.2408 | 0.4008 | 0.9939 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 7508.074 | uM | 13.21680 | 20.82640 | -0.6749 | -0.6730 | 1.8752 | 0.3501 | 0.9965 | 0.7924 | |
| MDA-MB-361 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 10999.156 | uM | 0.03525 | 0.12861 | -0.7418 | -0.5459 | 0.5701 | 0.7164 | 0.9016 | 0.4940 | |
| MDA-MB-361 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 12379.164 | uM | 0.00391 | 0.03155 | -0.8811 | -0.7211 | 0.4276 | 0.9830 | 0.9557 | 0.4318 | |
| MDA-MB-361 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 7507.084 | uM | 0.07258 | 0.09014 | -0.9768 | -0.9770 | 4.9989 | 0.8976 | 0.9982 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 7508.084 | uM | 0.06168 | 0.07680 | -0.9982 | -0.9967 | 4.9999 | 0.9083 | 0.9993 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 7506.085 | uM | 0.06910 | 0.08822 | -0.9793 | -0.9664 | 4.4045 | 0.8845 | 0.9995 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10643.137 | uM | inf | 6.50940 | 0.7332 | 0.7331 | 4.9998 | 0.0153 | 0.7892 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10999.149 | uM | inf | 5.87620 | 0.6617 | 0.6617 | 4.9590 | 0.0547 | 0.9163 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10999.154 | uM | inf | inf | 0.7597 | 0.7597 | 0.0000 | 0.0769 | -0.0123 | 0.7027 |