Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7511.074 | uM | 0.09189 | 0.13938 | -0.8458 | -0.7677 | 2.2329 | 0.9765 | 0.9962 | 1.2617 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 10938.145 | uM | inf | inf | -0.7748 | -0.7748 | 0.0000 | 0.6316 | 0.4642 | 1.1073 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 12333.17 | uM | 1.87440 | 1.82280 | 0.0467 | 0.0652 | 5.0000 | 0.2502 | 0.9202 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12959.177 | uM | 0.04903 | 0.06108 | -0.9997 | -0.9996 | 5.0000 | 0.9551 | 0.9974 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9664.12 | uM | 86.80630 | 181.19670 | -0.9811 | -1.0000 | 1.4929 | 0.3589 | 0.980 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7897.011 | uM | 264.53130 | 424.32160 | -0.7668 | -0.9070 | 2.1894 | 0.1984 | 0.9920 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7897.018 | uM | inf | inf | 0.8611 | 0.8611 | 0.0000 | 0.0755 | -0.1097 | 0.8448 | |
| MDA-MB-415 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9664.124 | uM | inf | inf | 0.9407 | 0.9407 | 0.0000 | -0.0184 | 0.0798 | 0.8433 | |
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9664.124 | uM | 28.40860 | 85.09720 | -0.9519 | -1.0000 | 1.0014 | 0.4499 | 0.8374 | 0.8433 | ||
| MDA-MB-415 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7897.018 | uM | 45.97130 | 379.0920 | -0.8720 | -1.0000 | 0.5207 | 0.5420 | 0.8753 | 0.8448 | ||
| MDA-MB-415 | HR+ | Luminal | Chloroquine | 12959.177 | uM | 5.27820 | 10.03080 | -0.9994 | -1.0000 | 1.7110 | 0.4009 | 0.9371 | 0.5538 | |||
| MDA-MB-415 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7897.035 | uM | 38.65720 | 56.84430 | -0.7395 | -0.7857 | 2.4494 | 0.2131 | 0.9933 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9664.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7193 | |
| MDA-MB-415 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 7897.007 | uM | 8.97980 | 17.41260 | -0.8093 | -0.9796 | 1.6383 | 0.3015 | 0.9699 | 0.8772 | |
| MDA-MB-415 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9664.121 | uM | 9.85150 | 20.34320 | -0.8115 | -1.0000 | 1.5151 | 0.2111 | 0.9952 | 0.7294 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 12333.155 | uM | inf | inf | 0.7859 | 0.7859 | 0.0000 | 0.4088 | 0.3155 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 10938.155 | uM | inf | inf | 0.6152 | 0.6152 | 0.0000 | 0.3282 | 0.3513 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12959.176 | uM | inf | inf | 0.7219 | 0.7219 | 0.0000 | 0.2500 | -1.1239 | 0.5779 | |
| MDA-MB-415 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13587.176 | uM | inf | inf | 0.8841 | 0.8841 | 0.0000 | 0.0658 | 0.2992 | 0.7367 | |
| MDA-MB-415 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 12959.174 | uM | 9.17640 | 26.76890 | -0.4756 | -1.0000 | 1.0262 | 0.3262 | 0.8405 | 0.5020 | |
| MDA-MB-415 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13587.174 | uM | 12.5020 | 17.09140 | -0.9911 | -1.0000 | 3.5135 | 0.2860 | 0.9699 | 0.6955 | |
| MDA-MB-415 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 12959.002 | uM | 0.01374 | 0.01598 | -0.2005 | -0.1966 | 2.1926 | 0.5937 | 0.9768 | 0.3805 | |
| MDA-MB-415 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 7897.002 | uM | 0.00266 | 0.00248 | 0.0526 | 0.0532 | 1.6034 | 0.6152 | 0.9806 | 0.8381 | |
| MDA-MB-415 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9664.002 | uM | 0.00223 | 0.00274 | -0.2371 | -0.2903 | 2.2103 | 0.8128 | 0.9836 | 0.5947 | |
| MDA-MB-415 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7897.007 | uM | 0.35013 | 0.44871 | -0.9997 | -0.6929 | 3.5049 | 0.7207 | 0.9579 | 0.8772 |