Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10999.15 | uM | 5.18730 | 0.35596 | 0.4787 | 0.4393 | 0.7871 | 0.2250 | 0.9020 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12379.169 | uM | 2.84960 | 1.58770 | 0.3859 | 0.4731 | 4.9984 | 0.1591 | 0.9361 | 0.5957 | |
| MDA-MB-415 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7897.016 | uM | 32.84980 | 48.58170 | -0.9480 | -1.0000 | 2.8076 | 0.2266 | 0.9871 | 0.7300 | ||
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9664.037 | uM | 0.09572 | 0.11439 | -0.9995 | -0.7190 | 5.0000 | 0.8937 | 0.9660 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7897.037 | uM | 0.01547 | 0.02922 | -0.9359 | -0.7663 | 1.4609 | 1.1406 | 0.9681 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 2-deoxyglucose | 12959.177 | uM | inf | inf | 0.3997 | 0.3997 | 0.0000 | 0.1758 | 0.1401 | 0.5538 | |||
| MDA-MB-415 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12333.143 | uM | 69.31480 | 1000.00000 | -0.2174 | -0.7755 | 0.3509 | 0.4155 | 0.8044 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10938.143 | uM | 2.97220 | 999.99980 | 0.0360 | -0.5648 | 0.1299 | 0.5525 | 0.8889 | 1.0173 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7897.035 | uM | 199.69580 | 698.60690 | -0.7189 | -0.8653 | 0.8021 | 0.5067 | 0.9935 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12333.165 | uM | 0.76831 | 1.79190 | -0.9988 | -1.0000 | 1.2973 | 0.7164 | 0.9035 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7511.066 | uM | inf | inf | 0.9792 | 0.9792 | 0.0000 | -0.0212 | -0.3797 | 1.1691 | |
| MDA-MB-415 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7512.066 | uM | inf | inf | 0.9738 | 0.9738 | 0.0000 | -0.0064 | -0.0661 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7510.066 | uM | inf | inf | 0.7164 | 0.7164 | 0.0000 | 0.1448 | 0.1074 | 0.9189 | |
| MDA-MB-415 | HR+ | Luminal | AG1478 | EGFR | ErbB | 7897.016 | uM | inf | inf | 0.7698 | 0.7698 | 0.0000 | 0.0413 | 0.3296 | 0.7300 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12333.165 | uM | inf | 0.00107 | 0.6376 | 0.6596 | 4.9998 | 0.2729 | 0.7587 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10938.153 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 7511.073 | uM | inf | 52.84510 | 0.6306 | 0.6292 | 4.8844 | 0.0134 | 0.9407 | 1.0909 | |
| MDA-MB-415 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10938.072 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5611 | |
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7512.074 | uM | 0.11726 | 0.18064 | -0.9205 | -0.8344 | 2.2716 | 1.0037 | 0.9881 | 0.9022 | |
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7512.074 | uM | 0.11726 | 0.18064 | -0.9205 | -0.8344 | 2.2716 | 1.0037 | 0.9881 | 0.9022 | |
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14845.203 | uM | 0.01985 | 0.04922 | -0.9548 | -0.8923 | 1.1277 | 1.0483 | 0.9930 | 0.7023 | |
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14845.203 | uM | 0.01985 | 0.04922 | -0.9548 | -0.8923 | 1.1277 | 1.0483 | 0.9930 | 0.7023 | |
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7510.074 | uM | 0.16354 | 0.20064 | -0.9653 | -0.8900 | 5.0000 | 0.9948 | 0.9955 | 0.7920 | |
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7510.074 | uM | 0.16354 | 0.20064 | -0.9653 | -0.8900 | 5.0000 | 0.9948 | 0.9955 | 0.7920 | |
| MDA-MB-415 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7511.074 | uM | 0.09189 | 0.13938 | -0.8458 | -0.7677 | 2.2329 | 0.9765 | 0.9962 | 1.2617 |