Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7898.017 | uM | 0.26568 | 3.85210 | -0.8480 | -1.0000 | 0.4108 | 0.6423 | 0.9082 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7900.017 | uM | 0.97766 | 1.11680 | -0.9886 | -0.4723 | 4.9987 | 0.5534 | 0.9133 | 0.5383 | |
| MDA-MB-436 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7899.017 | uM | 3.20650 | 10.28940 | -0.0707 | -0.3111 | 0.4149 | 0.3459 | 0.9247 | 2.0395 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7902.016 | uM | inf | inf | 0.6917 | 0.6917 | 0.0000 | 0.0572 | 0.2876 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 10266.024 | uM | inf | inf | 0.1508 | 0.1508 | 0.0000 | 0.1715 | 0.5163 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7898.016 | uM | 33.64070 | 37.69040 | 0.5161 | -0.3827 | 4.9998 | 0.0012 | 0.9236 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7900.012 | uM | 0.00157 | 0.00156 | -0.2721 | 0.0157 | 5.0000 | 0.8700 | 0.6184 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7898.04 | uM | 0.15745 | 0.10691 | 0.0350 | 0.2401 | 1.6905 | 0.4040 | 0.9062 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 10266.024 | uM | 0.05746 | 0.08750 | -0.2843 | -0.1227 | 0.5217 | 0.5902 | 0.9184 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10266.131 | uM | -inf | 0.00975 | -0.9900 | -1.0000 | 0.1117 | 1.3424 | 0.6662 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7900.011 | uM | 0.06723 | 0.07509 | -0.1058 | -0.0978 | 1.6154 | 0.7042 | 0.7985 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7898.011 | uM | 0.03270 | 0.03486 | -0.2459 | -0.1245 | 3.4756 | 0.7520 | 0.9623 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7902.075 | uM | 0.05068 | 0.03698 | 0.1485 | 0.1761 | 1.3785 | 0.6315 | 0.9687 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10266.011 | uM | 0.02860 | 0.03214 | -0.5466 | -0.3964 | 4.9995 | 0.9392 | 0.9813 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7900.001 | uM | 0.03947 | 1.61930 | -0.7009 | -1.0000 | 0.2958 | 0.6061 | 0.7089 | 0.7944 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7902.001 | uM | 0.54959 | 23.68160 | -0.1816 | -1.0000 | 0.2919 | 0.3808 | 0.7924 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7899.001 | uM | 0.71670 | 1.01170 | -0.0366 | -0.0889 | 0.4748 | 0.3065 | 0.8762 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7898.001 | uM | 0.10945 | 0.73566 | -0.4589 | -0.6440 | 0.4344 | 0.5284 | 0.9251 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 10266.001 | uM | 0.05908 | 0.06633 | -0.3222 | -0.1740 | 2.5780 | 0.5795 | 0.9469 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7900.001 | uM | 0.03727 | 0.03981 | -0.5333 | -0.1951 | 5.0000 | 0.6629 | 0.8563 | 0.7944 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7902.001 | uM | 0.00296 | 0.00205 | 0.3678 | 0.4200 | 5.0000 | 0.4307 | 0.9112 | 1.9359 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7899.001 | uM | 0.02210 | 0.00549 | 0.3607 | 0.4166 | 1.2863 | 0.3825 | 0.9565 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 10266.001 | uM | 0.01358 | 0.01386 | -0.2223 | -0.0556 | 4.9998 | 0.6171 | 0.9643 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7898.001 | uM | 0.01767 | 0.01948 | -0.2097 | -0.1217 | 2.2342 | 0.6544 | 0.9777 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7902.001 | uM | 0.07096 | 0.01408 | 0.2360 | 0.3855 | 0.9113 | 0.3756 | 0.7453 | 1.9359 |