Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7902.075 | uM | 118.40350 | 357.34250 | -0.4322 | -0.8612 | 0.9067 | 0.2472 | 0.9750 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10266.011 | uM | 37.83660 | 78.33250 | -0.9465 | -0.9553 | 1.4682 | 0.4132 | 0.9960 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7898.011 | uM | 64.56580 | 150.0140 | -0.7335 | -0.8568 | 1.1841 | 0.3063 | 0.9972 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7902.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0247 | -0.1948 | 1.8686 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7900.018 | uM | inf | inf | 0.5694 | 0.5694 | 0.0000 | 0.2033 | -0.0548 | 0.8304 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7898.018 | uM | inf | inf | 0.9583 | 0.9583 | 0.0000 | -0.0243 | -0.0431 | 1.1279 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7899.018 | uM | inf | inf | 0.8519 | 0.8519 | 0.0000 | 0.0052 | 0.3918 | 2.0432 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 10266.026 | uM | inf | inf | 0.7319 | 0.7319 | 0.0000 | 0.0071 | 0.5379 | 0.6682 | |
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7900.018 | uM | inf | inf | -0.7506 | -0.7506 | 0.0000 | 0.4724 | 0.5038 | 0.8304 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7902.018 | uM | 788.84610 | 1000.00000 | 0.1746 | -0.0490 | 0.3938 | 0.2081 | 0.7743 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7899.018 | uM | 667.12150 | 1000.00000 | 0.1240 | -0.0951 | 0.4301 | 0.2248 | 0.8264 | 2.0432 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10266.026 | uM | 105.61670 | 682.00580 | -0.8390 | -1.0000 | 0.5890 | 0.4418 | 0.8587 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7898.018 | uM | 270.00490 | 1000.00000 | -0.4846 | -0.8278 | 0.7459 | 0.3170 | 0.9412 | 1.1279 | ||
| MDA-MB-436 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10266.131 | uM | 4.16110 | 16.58770 | -0.8545 | -1.0000 | 0.7944 | 0.5169 | 0.9207 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7899.017 | uM | 14.41330 | 10.98960 | 0.1815 | 0.1119 | 0.9339 | 0.2269 | 0.9458 | 2.0395 | |
| MDA-MB-436 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7900.017 | uM | 32.06580 | 39.47310 | -0.9130 | -0.9134 | 5.0000 | 0.3289 | 0.9461 | 0.5383 | |
| MDA-MB-436 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7898.017 | uM | 9.28230 | 25.36090 | -0.6357 | -0.8276 | 0.9716 | 0.3684 | 0.9752 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7902.13 | uM | 14.33020 | 51.3290 | -0.3940 | -0.8151 | 0.7580 | 0.2813 | 0.9798 | 1.7664 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7899.077 | uM | 20.82040 | 23.70910 | 0.1579 | -0.0699 | 1.0071 | 0.1185 | 0.9630 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 10266.121 | uM | 6.24460 | 16.04830 | -0.5125 | -0.7857 | 1.0006 | 0.2210 | 0.9847 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10266.002 | uM | 0.00837 | 0.00966 | -0.2028 | -0.1558 | 1.8929 | 0.6382 | 0.9706 | 0.6757 | |
| MDA-MB-436 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7898.002 | uM | 0.01765 | 0.01745 | 0.1055 | 0.0273 | 5.0000 | 0.4702 | 0.9780 | 1.1328 | |
| MDA-MB-436 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7900.002 | uM | 0.03316 | 0.04001 | -0.3784 | -0.2722 | 2.3158 | 0.5196 | 0.9828 | 0.4748 | |
| MDA-MB-436 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7899.077 | uM | 0.63399 | 0.46557 | 0.1078 | 0.2163 | 1.8350 | 0.3205 | 0.9702 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 10266.121 | uM | 0.57811 | 0.64880 | -0.6038 | -0.3901 | 4.9993 | 0.5387 | 0.9724 | 0.7110 |