Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9648.012 | uM | inf | inf | 0.8401 | 0.8401 | 0.0000 | -0.0369 | 0.4891 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7896.05 | uM | inf | inf | 0.8009 | 0.8009 | 0.0000 | 0.0341 | 0.5481 | 0.9241 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7894.05 | uM | inf | 0.00198 | 0.5609 | 0.7483 | 2.9483 | 0.1670 | 0.6357 | 0.7608 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7505.05 | uM | 21.94740 | 24.13160 | 0.8214 | -0.3035 | 4.9994 | 0.0147 | 0.6601 | 0.9037 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7895.05 | uM | inf | 996.89040 | 0.7547 | -0.1743 | 0.3520 | 0.0528 | 0.7821 | 1.1017 | |
| MDA-MB-361 | HER2amp | Luminal | Trametinib | MEK | MAPK | 10095.012 | uM | inf | 1.33090 | 0.7165 | 0.6353 | 0.4959 | 0.0872 | 0.9845 | 0.8966 | |
| MDA-MB-361 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9648.026 | uM | inf | 0.00320 | 0.3886 | 0.5402 | 1.5326 | 0.2764 | 0.8808 | 0.7065 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7508.065 | uM | 3.12410 | 7.26230 | -0.9882 | -1.0000 | 1.3024 | 1.0464 | 0.9860 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7507.065 | uM | 8.78480 | 11.99920 | -0.9707 | -0.9713 | 3.4613 | 0.9352 | 0.9972 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7506.065 | uM | 8.12750 | 10.77710 | -0.9395 | -0.9410 | 3.7513 | 0.9322 | 0.9978 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 7506.074 | uM | inf | 0.29172 | 0.5221 | 0.5207 | 0.5995 | 0.1853 | 0.9039 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 7507.074 | uM | 17.11480 | 86.79730 | 0.4340 | -0.3926 | 0.3570 | 0.1620 | 0.9153 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 7508.074 | uM | 60.88170 | 0.75645 | 0.5210 | 0.3771 | 0.3198 | 0.2126 | 0.9233 | 0.7924 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 10999.143 | uM | 708.13210 | 1000.00000 | -0.9987 | -0.5593 | 2.1752 | 0.2507 | 0.8852 | 0.5216 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 10643.143 | uM | 573.8690 | 1000.00000 | -0.9989 | -0.6639 | 1.5214 | 0.3323 | 0.9046 | 0.4866 | |
| MDA-MB-361 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12379.143 | uM | 450.79670 | 972.52820 | -0.9995 | -1.0000 | 1.4288 | 0.4119 | 0.9965 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7896.042 | uM | inf | inf | -0.9577 | -0.9577 | 0.0000 | 1.2088 | 0.4007 | 1.1632 | |
| MDA-MB-361 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7895.018 | uM | 0.00973 | 0.01406 | -0.9311 | -0.5423 | 1.9942 | 0.9455 | 0.9539 | 1.2916 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 7506.065 | uM | 58.0050 | 106.92690 | -0.9509 | -0.9678 | 1.7607 | 0.8280 | 0.9897 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 7507.065 | uM | 53.25920 | 115.37960 | -0.9756 | -1.0000 | 1.4211 | 0.8304 | 0.9941 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 7508.065 | uM | 44.19490 | 88.7310 | -0.9914 | -1.0000 | 1.5762 | 0.8387 | 0.9977 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 10999.151 | uM | 0.31174 | 0.34620 | -0.2351 | -0.3446 | 5.0000 | 0.6082 | 0.9731 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 12379.157 | uM | 0.93556 | 1.07060 | -0.5453 | -0.4810 | 5.0000 | 0.5227 | 0.9875 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 10643.139 | uM | 1.26840 | 1.49340 | -0.2555 | -0.2435 | 2.4294 | 0.4028 | 0.9958 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10643.138 | uM | 18.37680 | 28.88720 | -0.9928 | -1.0000 | 2.4289 | 0.3131 | 0.8880 | 0.4981 |