Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7896.016 | uM | 2.41090 | 1.76380 | 0.2423 | 0.3952 | 5.0000 | 0.2011 | 0.9175 | 0.8912 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7895.016 | uM | 14.62070 | 42.06130 | -0.7058 | -1.0000 | 1.0397 | 0.2695 | 0.9848 | 1.2977 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7505.016 | uM | 9.56020 | 7.19810 | 0.3631 | 0.3739 | 4.8550 | 0.1270 | 0.9890 | 1.0721 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 12379.165 | uM | 13.32740 | 22.35950 | -0.4017 | -1.0000 | 2.1232 | 0.1570 | 0.9461 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 10999.153 | uM | 17.58280 | 35.76950 | 0.3266 | -0.3866 | 0.8066 | 0.0966 | 0.9640 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 10643.141 | uM | 11.52480 | 19.71840 | -0.8544 | -1.0000 | 2.0456 | 0.2025 | 0.9924 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10999.072 | uM | inf | inf | 0.9315 | 0.9315 | 0.0000 | 0.0176 | 0.0119 | 0.7551 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 7506.073 | uM | 210.65320 | 209.41650 | 0.7332 | 0.0128 | 4.3964 | -0.0021 | 0.8478 | 0.9958 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10472.072 | uM | inf | 43.4090 | 0.6069 | 0.6059 | 4.4140 | 0.0339 | 0.9076 | 0.6135 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10643.072 | uM | 139.8590 | 163.75380 | 0.1605 | -0.6002 | 4.9999 | 0.0146 | 0.9776 | 0.6128 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7506.074 | uM | 1142.02650 | 79.87280 | 0.6162 | 0.3688 | 0.5028 | 0.0808 | 0.9323 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7506.074 | uM | 1142.02650 | 79.87280 | 0.6162 | 0.3688 | 0.5028 | 0.0808 | 0.9323 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7508.074 | uM | 25.2250 | 18.20490 | 0.2166 | 0.1194 | 0.8366 | 0.1346 | 0.9643 | 0.7924 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7508.074 | uM | 25.2250 | 18.20490 | 0.2166 | 0.1194 | 0.8366 | 0.1346 | 0.9643 | 0.7924 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7507.074 | uM | 6.14380 | 59.72970 | -0.2740 | -1.0000 | 0.4830 | 0.3065 | 0.9817 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7507.074 | uM | 6.14380 | 59.72970 | -0.2740 | -1.0000 | 0.4830 | 0.3065 | 0.9817 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14767.203 | uM | 0.01240 | 0.02303 | -0.8101 | -0.6784 | 1.3851 | 1.0449 | 0.9850 | 1.0253 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14767.203 | uM | 0.01240 | 0.02303 | -0.8101 | -0.6784 | 1.3851 | 1.0449 | 0.9850 | 1.0253 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 10999.145 | uM | 1.20710 | 1.48890 | -0.2166 | -0.2230 | 1.7578 | 0.4530 | 0.9586 | 0.7621 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 10643.145 | uM | 0.94868 | 1.88120 | -0.6683 | -0.6633 | 1.2334 | 0.5056 | 0.9928 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 12379.17 | uM | 1.26110 | 1.5010 | -0.6583 | -0.6497 | 4.7811 | 0.3770 | 0.9984 | 0.5805 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12989.177 | uM | 0.19876 | 0.30381 | -1.0000 | -1.0000 | 2.5891 | 0.7753 | 0.9758 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9648.011 | uM | 41.9650 | 116.5730 | -0.8091 | -0.9392 | 1.0348 | 0.3751 | 0.9946 | 0.6920 | |
| MDA-MB-361 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7896.011 | uM | 76.08920 | 168.42030 | -0.6310 | -0.7668 | 1.1700 | 0.2842 | 0.9954 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10095.021 | uM | 46.19340 | 66.44160 | -0.5371 | -0.5631 | 2.0754 | 0.3790 | 0.9975 | 0.9164 |