Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-175-VII
HR+
Luminal
 FTase Inhibitor I
Ftase
MAPK
12126.154
uM
inf
inf
 0.6563 0.6563 0.0000 0.2735
-0.1456
 0.6012
MDA-MB-175-VII
HR+
Luminal
 FTase Inhibitor I
Ftase
MAPK
10818.154
uM
inf
inf
 0.8900 0.8900 0.0000 0.0571
-0.1057
 0.5056
MDA-MB-175-VII
HR+
Luminal
 FTase Inhibitor I
Ftase
MAPK
10642.142
uM
inf
inf
 1.0500 1.0500 0.0000 0.0208
0.0000
 0.5006
MDA-MB-175-VII
HR+
Luminal
 Gefitinib
EGFR
ErbB
7885.016
uM
0.23630
0.50459
 -0.7802 -0.7534 1.2114 0.6452
0.9401
 0.7137
MDA-MB-175-VII
HR+
Luminal
 Gefitinib
EGFR
ErbB
7886.016
uM
0.14084
0.47182
 -0.9508 -0.9672 0.8904 0.6601
0.9949
 0.7194
MDA-MB-175-VII
HR+
Luminal
 Gefitinib
EGFR
ErbB
7884.016
uM
0.47631
0.73937
 -0.9300 -0.8658 2.2852 0.5216
0.9965
 0.4603
MDA-MB-175-VII
HR+
Luminal
 Geldanamycin
HSP90
HSP90
7886.04
uM
0.01509
0.01945
 -0.5854 -0.5556 2.9455 1.0357
0.9980
 0.7771
MDA-MB-175-VII
HR+
Luminal
 Gemcitabine
DNA replication
DNA replication
7885.011
uM
0.00714
0.00693
 0.0079 0.0681 5.0000 0.7470
0.9256
 0.5102
MDA-MB-175-VII
HR+
Luminal
 Gemcitabine
DNA replication
DNA replication
7886.011
uM
0.00562
0.00512
 -0.0228 0.0707 1.6531 0.7393
0.9469
 0.6942
MDA-MB-175-VII
HR+
Luminal
 Glycyl-H-1152
ROCK2
12126.16
uM
inf
inf
 0.7655 0.7655 0.0000 0.2418
0.0000
 0.6930
MDA-MB-175-VII
HR+
Luminal
 Glycyl-H-1152
ROCK2
10818.15
uM
inf
inf
 1.0023 1.0023 0.0000 0.1451
0.0029
 0.4390
MDA-MB-175-VII
HR+
Luminal
 Glycyl-H-1152
ROCK2
10642.138
uM
inf
inf
 0.7146 0.7146 0.0000 0.1815
0.0686
 0.5620
MDA-MB-175-VII
HR+
Luminal
 GSK1070916
AURK
AURK
7884.001
uM
6.05390
9.41410
 -0.9771 -1.0000 2.4883 0.3526
0.8689
 0.5364
MDA-MB-175-VII
HR+
Luminal
 GSK1070916
AURK
AURK
7886.001
uM
8.61980
10.66740
 -0.8844 -0.8923 4.8052 0.2094
0.9501
 0.7999
MDA-MB-175-VII
HR+
Luminal
 GSK1070916
AURK
AURK
7885.001
uM
14.54190
19.70290
 -0.4939 -0.7859 3.1100 0.1099
0.9765
 0.6265
MDA-MB-175-VII
HR+
Luminal
 GSK1838705A
IGF1R
RTK
7500.098
uM
6.87270
3.64120
 0.2805 0.4791 5.0000 0.1344
0.7777
 0.7767
MDA-MB-175-VII
HR+
Luminal
 GSK1838705A
IGF1R
RTK
7499.09
uM
14.12530
215.67680
 0.0070 -1.0000 0.4030 0.2288
0.7968
 0.9238
MDA-MB-175-VII
HR+
Luminal
 GSK1838705A
IGF1R
RTK
7499.07
uM
3.18620
4.13560
 -0.9821 -0.9864 4.1772 0.5020
0.9759
 0.7073
MDA-MB-175-VII
HR+
Luminal
 GSK1838705A
IGF1R
RTK
7500.091
uM
47.01170
59.85550
 -0.7435 -0.8147 4.0025 0.1249
0.9785
 0.6237
MDA-MB-175-VII
HR+
Luminal
 GSK1838705A
IGF1R
RTK
7500.071
uM
5.09520
6.28580
 -0.9749 -0.9287 4.9998 0.4512
0.9920
 0.8688
MDA-MB-175-VII
HR+
Luminal
 GSK1838705A
IGF1R
RTK
7499.098
uM
4.77910
5.95350
 -0.9866 -1.0000 5.0000 0.3604
0.9983
 0.6421
MDA-MB-175-VII
HR+
Luminal
 GSK461364
PLK1
PLK
7884.001
uM
inf
inf
 -0.7398 -0.7398 0.0000 0.5921
0.3286
 0.5364
MDA-MB-175-VII
HR+
Luminal
 GSK461364
PLK1
PLK
7886.001
uM
inf
inf
 -0.9822 -0.9822 0.0000 0.4835
0.4966
 0.7999
MDA-MB-175-VII
HR+
Luminal
 GSK461364
PLK1
PLK
7885.001
uM
8.81610
15.27210
 -0.6546 -1.0000 1.9995 0.2504
0.8039
 0.6265
MDA-MB-175-VII
HR+
Luminal
 GSK923295
CENPE
Kinesin
7886.001
uM
0.06110
0.05080
 -0.0752 0.3012 5.0000 0.3217
0.8270
 0.7999