Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-175-VII
HR+
Luminal
 GSK923295
CENPE
Kinesin
7884.001
uM
0.03097
0.03414
 -0.4481 -0.0900 1.7001 0.5764
0.9033
 0.5364
MDA-MB-175-VII
HR+
Luminal
 GSK923295
CENPE
Kinesin
7885.001
uM
0.15528
0.08830
 0.0952 0.3114 1.7270 0.2942
0.9150
 0.6265
MDA-MB-175-VII
HR+
Luminal
 GW843682X
PLK
PLK
10642.139
uM
inf
inf
 0.8856 0.8856 0.0000 0.0467
0.0078
 0.7017
MDA-MB-175-VII
HR+
Luminal
 Ibandronate
FDPS
10642.143
uM
14.68780
50.81510
 -0.9195 -1.0000 0.8851 0.6829
0.8879
 0.5076
MDA-MB-175-VII
HR+
Luminal
 Ibandronate
FDPS
10818.143
uM
29.27380
68.90020
 -0.8212 -0.9190 1.2186 0.6018
0.9085
 0.6263
MDA-MB-175-VII
HR+
Luminal
 Ibandronate
FDPS
12126.143
uM
83.13350
138.95970
 -0.8487 -0.8720 1.9648 0.4595
0.9467
 0.6729
MDA-MB-175-VII
HR+
Luminal
 ICRF-193
TOP2
TOP
10642.139
uM
inf
inf
 0.8934 0.8934 0.0000 0.0557
-0.0365
 0.7017
MDA-MB-175-VII
HR+
Luminal
 ICRF-193
TOP2
TOP
12126.157
uM
inf
inf
 0.7186 0.7186 0.0000 0.2323
0.2360
 0.7555
MDA-MB-175-VII
HR+
Luminal
 ICRF-193
TOP2
TOP
10818.151
uM
inf
2.74760
 0.7835 0.7584 1.0048 0.0557
0.6193
 0.4459
MDA-MB-175-VII
HR+
Luminal
 Imatinib
ABL/KIT/PDGFR
nRTK
7499.09
uM
6.18820
13.53550
 -0.9990 -1.0000 1.4037 0.6428
0.9856
 0.9238
MDA-MB-175-VII
HR+
Luminal
 Imatinib
ABL/KIT/PDGFR
nRTK
7500.091
uM
14.29550
19.80740
 -0.9993 -0.9996 3.3680 0.5434
0.9889
 0.6237
MDA-MB-175-VII
HR+
Luminal
 Ispinesib
KSP
Kinesin
7500.067
uM
0.11677
1.55590
 -0.9993 -1.0000 0.4242 0.5568
0.7848
 0.7143
MDA-MB-175-VII
HR+
Luminal
 Ispinesib
KSP
Kinesin
7499.067
uM
0.38970
3.18410
 -0.9999 -1.0000 0.5230 0.4627
0.8282
 0.7759
MDA-MB-175-VII
HR+
Luminal
 Ixabepilone
TUBB
TUBB
7500.095
uM
0.01082
0.57770
 -0.9986 -1.0000 0.2762 0.7708
0.6111
 0.4619
MDA-MB-175-VII
HR+
Luminal
 Ixabepilone
TUBB
TUBB
7499.094
uM
0.00935
0.32584
 -0.9999 -1.0000 0.3094 1.0308
0.8764
 0.6407
MDA-MB-175-VII
HR+
Luminal
 JNK-IN-5A
JNK
JNK
10818.144
uM
inf
inf
 0.3384 0.3384 0.0000 0.1520
0.3008
 0.4912
MDA-MB-175-VII
HR+
Luminal
 JNK-IN-5A
JNK
JNK
12126.144
uM
inf
inf
 0.7596 0.7596 0.0000 0.1516
0.4109
 0.6379
MDA-MB-175-VII
HR+
Luminal
 JNK-IN-5A
JNK
JNK
10642.144
uM
9.52720
18.16140
 0.1742 -0.1764 0.4685 0.2838
0.8052
 0.6510
MDA-MB-175-VII
HR+
Luminal
 L-779450
BRAF
MAPK
12126.161
uM
7.54790
16.90510
 -0.7317 -1.0000 1.3625 0.4061
0.7165
 0.6227
MDA-MB-175-VII
HR+
Luminal
 L-779450
BRAF
MAPK
10818.149
uM
5.19560
8.67450
 -0.1184 -0.3778 1.0980 0.2357
0.8850
 0.4210
MDA-MB-175-VII
HR+
Luminal
 L-779450
BRAF
MAPK
10642.137
uM
9.22370
8.72110
 0.1213 0.1200 4.8986 0.0683
0.9852
 0.6570
MDA-MB-175-VII
HR+
Luminal
 Lapatinib
EGFR/HER2
ErbB
7499.098
uM
0.86961
0.84874
 -0.0283 0.0572 4.9999 0.1750
0.9799
 0.6421
MDA-MB-175-VII
HR+
Luminal
 Lapatinib
EGFR/HER2
ErbB
7500.098
uM
0.95570
1.37580
 -0.4556 -0.4748 1.8326 0.3023
0.9865
 0.7767
MDA-MB-175-VII
HR+
Luminal
 LBH589
HDAC
HDAC
12126.154
uM
0.27124
0.50934
 -0.9836 -1.0000 1.7435 0.7744
0.9444
 0.6012
MDA-MB-175-VII
HR+
Luminal
 LBH589
HDAC
HDAC
10818.154
uM
0.37589
0.64398
 -0.9294 -0.9170 1.9349 0.6408
0.9843
 0.5056