Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 12333.143 | uM | 418.62780 | 1000.00000 | -0.9943 | -0.8308 | 1.1242 | 0.4105 | 0.9244 | 0.6265 | |
| MDA-MB-415 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7897.018 | uM | 0.0090 | 0.78301 | -0.9931 | -1.0000 | 0.2460 | 0.7416 | 0.7145 | 0.8448 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7511.065 | uM | 92.6020 | 167.9820 | -0.3886 | -0.3733 | 0.9364 | 0.5166 | 0.9759 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7512.065 | uM | 103.56830 | 236.51880 | -0.7101 | -0.6512 | 1.0099 | 0.5457 | 0.9866 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7510.065 | uM | 26.15970 | 82.36390 | -0.9294 | -0.9035 | 0.8999 | 0.7898 | 0.9968 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12333.157 | uM | 0.32702 | 0.57123 | -0.1662 | -0.1904 | 0.5785 | 0.5675 | 0.7835 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10938.151 | uM | 0.38040 | 0.81809 | 0.0984 | -0.1378 | 0.3179 | 0.4841 | 0.8690 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14272.189 | uM | 2.20420 | 2.67710 | -0.9706 | -0.8214 | 5.0000 | 0.4742 | 0.9888 | 0.5095 | |
| MDA-MB-415 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14643.189 | uM | 2.41270 | 3.99890 | -0.9475 | -0.9549 | 2.1139 | 0.4725 | 0.9914 | 0.8604 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10938.15 | uM | inf | inf | 0.5380 | 0.5380 | 0.0000 | 0.3086 | -0.0630 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 12333.169 | uM | 1.39820 | 1.39170 | 0.0058 | 0.0056 | 2.3772 | 0.3754 | 0.8602 | 0.5536 | |
| MDA-MB-436 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7902.016 | uM | inf | inf | 0.4502 | 0.4502 | 0.0000 | 0.1492 | 0.4514 | 1.9004 | ||
| MDA-MB-436 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7898.016 | uM | 29.22070 | 36.11050 | -0.9401 | -0.9411 | 5.0000 | 0.2132 | 0.9955 | 1.2127 | ||
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7900.037 | uM | inf | inf | -0.8433 | -0.8433 | 0.0000 | 0.8378 | 0.4634 | 0.6692 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7898.04 | uM | 0.58578 | 10.25510 | -0.4945 | -0.9595 | 0.3742 | 0.4546 | 0.9152 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7902.05 | uM | 1.83740 | 39.29570 | -0.2709 | -1.0000 | 0.3587 | 0.3653 | 0.9205 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 10266.037 | uM | 0.31469 | 3.51830 | -0.8011 | -1.0000 | 0.4551 | 0.5489 | 0.9312 | 0.7695 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7900.017 | uM | inf | inf | -0.7673 | -0.7673 | 0.0000 | 0.4436 | 0.5715 | 0.5383 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7902.13 | uM | 1146.91030 | 1000.00000 | 0.0429 | 0.0537 | 0.8283 | 0.2226 | 0.9182 | 1.7664 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7898.017 | uM | 385.62260 | 1000.00000 | -0.2547 | -0.3782 | 0.5911 | 0.3494 | 0.9419 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 10266.131 | uM | 533.61270 | 1000.00000 | -0.2395 | -0.2706 | 0.6887 | 0.3018 | 0.9529 | 0.8552 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7899.017 | uM | 1312.87080 | 1000.00000 | 0.1139 | 0.0885 | 0.7154 | 0.2058 | 0.9704 | 2.0395 | |
| MDA-MB-436 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7898.016 | uM | inf | inf | 0.7881 | 0.7881 | 0.0000 | 0.0310 | 0.3510 | 1.2127 | |
| MDA-MB-436 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7902.016 | uM | 43.3210 | 43.06220 | 0.0159 | 0.0147 | 4.9808 | 0.1679 | 0.7461 | 1.9004 | |
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7900.011 | uM | 64.38830 | 99.96110 | -0.9386 | -0.9392 | 2.4037 | 0.5006 | 0.7713 | 0.5977 |