Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 12414.155 | uM | 39.26240 | 41.19550 | 0.6846 | -0.1173 | 4.3855 | 0.0557 | 0.5773 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 12414.155 | uM | 39.26240 | 41.19550 | 0.6846 | -0.1173 | 4.3855 | 0.0557 | 0.5773 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7517.095 | uM | inf | inf | 0.6190 | 0.6190 | 0.0000 | 0.4058 | 0.0000 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7518.095 | uM | inf | inf | 0.8558 | 0.8558 | 0.0000 | 0.0847 | 0.0759 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7515.095 | uM | inf | inf | 0.4487 | 0.4487 | 0.0000 | 0.4056 | 0.3245 | 0.9628 | |
| MDA-MB-453 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7516.095 | uM | inf | inf | 0.1417 | 0.1417 | 0.0000 | 0.2650 | 0.3783 | 1.3423 | |
| MDA-MB-453 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7518.065 | uM | inf | inf | 0.9324 | 0.9324 | 0.0000 | -0.0310 | -0.1509 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7515.065 | uM | inf | inf | 0.7626 | 0.7626 | 0.0000 | 0.1588 | 0.0295 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7516.065 | uM | inf | inf | 0.8456 | 0.8456 | 0.0000 | 0.0909 | 0.0484 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7517.065 | uM | inf | 75.32750 | 0.8491 | 0.8330 | 0.5724 | 0.0481 | 0.7757 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 7518.067 | uM | inf | inf | 0.8749 | 0.8749 | 0.0000 | 0.2698 | -0.1447 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 7517.067 | uM | inf | 2.62770 | 0.9085 | 0.8391 | 4.6694 | 0.0251 | 0.5929 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ribavirin | 15398.211 | uM | inf | inf | 0.8982 | 0.8982 | 0.0000 | 0.0145 | 0.1417 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | SB-3CT | MMP2/9 | MMP | 12414.168 | uM | inf | 4.03070 | 0.5643 | 0.6238 | 1.6484 | 0.1458 | 0.8451 | 1.2069 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 12414.155 | uM | inf | 4.06690 | 0.7350 | 0.7375 | 5.0000 | 0.0483 | 0.8704 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Sigma A6730 | AKT | AKT | 12414.165 | uM | 1.99070 | 4.41480 | -0.9516 | -1.0000 | 1.3794 | 0.4333 | 0.9973 | 1.2459 | |
| MDA-MB-453 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7518.069 | uM | 0.07350 | 0.03663 | 0.1491 | 0.1266 | 0.4191 | 0.4555 | 0.9895 | 1.5543 | |
| MDA-MB-453 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7517.084 | uM | inf | inf | 0.8484 | 0.8484 | 0.0000 | 0.1100 | -0.0346 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7518.084 | uM | inf | 14.81730 | 0.5714 | 0.5599 | 4.9933 | 0.1318 | 0.8275 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7517.067 | uM | inf | inf | -0.9439 | -0.9439 | 0.0000 | 0.3480 | 0.4207 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7518.067 | uM | 5.55180 | 6.91490 | -0.9997 | -0.9988 | 5.0000 | 0.5773 | 0.8581 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 7903.002 | uM | 0.00625 | 0.00804 | -0.5025 | -0.4695 | 2.6296 | 0.9842 | 0.9884 | 1.2202 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 9708.002 | uM | 0.00970 | 0.01172 | -0.2544 | -0.1950 | 1.7464 | 0.7160 | 0.9893 | 1.0482 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 12964.002 | uM | 0.00864 | 0.01139 | -0.5617 | -0.5234 | 2.5980 | 0.9297 | 0.9952 | 0.5925 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 9723.002 | uM | 0.01302 | 0.01943 | -0.4095 | -0.4017 | 1.4740 | 0.8003 | 0.9958 | 0.8443 |