Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 12414.152 | uM | 0.50553 | 1.08480 | -0.9065 | -0.9704 | 1.4127 | 0.5655 | 0.9927 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12414.135 | uM | inf | inf | 1.0132 | 1.0132 | 0.0000 | 0.0212 | 0.0000 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Temsirolimus | MTOR | MTOR | 12414.168 | uM | 0.05955 | 0.08128 | -0.0936 | -0.0982 | 0.5763 | 0.6266 | 0.9962 | 1.2069 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 10270.121 | uM | 0.14056 | 0.29065 | -0.8760 | -0.8421 | 1.3591 | 0.8697 | 0.9686 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 9723.121 | uM | 0.06218 | 0.23448 | -0.7987 | -0.8193 | 0.7310 | 0.8811 | 0.9748 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 9708.121 | uM | 0.08870 | 0.29548 | -0.8106 | -0.7698 | 0.7745 | 0.7917 | 0.9820 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Torkinib | 15398.211 | uM | 0.00074 | 0.00583 | -0.5991 | -0.5679 | 0.3671 | 1.0368 | 0.9859 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12414.169 | uM | 6.67560 | 21.40740 | -0.9457 | -1.0000 | 0.9428 | 0.3655 | 0.8501 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | TPCA-1 | IKK | NFKB | 7515.093 | uM | inf | inf | 0.6019 | 0.6019 | 0.0000 | 0.2286 | 0.2488 | 1.3657 | |
| MDA-MB-453 | TNBC | Luminal | TPCA-1 | IKK | NFKB | 7516.093 | uM | 33.61170 | 826.26780 | 0.3961 | -1.0000 | 0.3431 | 0.1869 | 0.7526 | 1.3148 | |
| MDA-MB-453 | TNBC | Luminal | TPCA-1 | IKK | NFKB | 7517.093 | uM | inf | 4.67630 | 0.5890 | 0.5711 | 1.6784 | 0.1190 | 0.860 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 9708.012 | uM | 0.19657 | 0.08096 | 0.4504 | 0.4941 | 5.0000 | 0.2016 | 0.9603 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 7903.036 | uM | 0.74469 | 0.08519 | 0.4768 | 0.4909 | 1.8495 | 0.2114 | 0.9952 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trastuzumab | HER2 | ErbB | 9723.124 | uM | inf | 0.00115 | 0.4864 | 0.6553 | 4.9994 | 0.2269 | 0.8119 | 0.9827 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7515.065 | uM | 5.54120 | 6.82290 | -0.9261 | -0.9152 | 5.0000 | 1.0313 | 0.9902 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7516.065 | uM | 4.19160 | 6.69590 | -0.9507 | -0.9386 | 2.2561 | 1.0270 | 0.9960 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7518.065 | uM | 6.48560 | 9.99410 | -0.9220 | -0.8945 | 2.3719 | 0.8994 | 0.9990 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7517.065 | uM | 3.12630 | 5.0010 | -0.9205 | -0.8943 | 2.1829 | 1.0174 | 0.9997 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Triciribine | AKT | AKT | 7518.074 | uM | 0.12458 | 0.06726 | 0.1573 | 0.1405 | 0.5351 | 0.4048 | 0.9705 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Triciribine | AKT | AKT | 7517.074 | uM | 0.13283 | 0.24464 | 0.0317 | -0.1306 | 0.3800 | 0.4546 | 0.9905 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 12414.143 | uM | 540.73010 | 1000.00000 | -0.9149 | -0.7955 | 1.5484 | 0.3968 | 0.9734 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 9708.006 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 1.6076 | 0.3995 | 0.6313 | |
| MDA-MB-453 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7903.042 | uM | 0.00441 | 0.00494 | -0.9524 | -0.3548 | 4.7159 | 0.9002 | 0.8859 | 1.1508 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7515.065 | uM | 22.35370 | 34.68390 | -0.9186 | -0.8960 | 2.3373 | 0.9996 | 0.9606 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7516.065 | uM | 30.41320 | 45.04420 | -0.9445 | -0.9409 | 2.6948 | 0.9429 | 0.9934 | 1.3224 |