Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Temsirolimus | MTOR | MTOR | 10874.144 | uM | 1.21660 | 8.77790 | -0.9941 | -1.0000 | 0.5559 | 0.5000 | 0.9217 | 0.7282 | |
| MX1 | Unknown | Unknown | Temsirolimus | MTOR | MTOR | 10644.144 | uM | 7.08820 | 15.7050 | -0.9998 | -1.0000 | 1.3809 | 0.3582 | 0.9868 | 0.5357 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10644.138 | uM | 0.49260 | 0.61118 | -0.9998 | -0.9701 | 5.0000 | 0.8876 | 0.9713 | 0.5624 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10874.15 | uM | 0.11068 | 0.36637 | -0.8552 | -0.8793 | 0.8477 | 0.6723 | 0.9865 | 0.9133 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12220.16 | uM | 0.19982 | 0.24291 | -0.9386 | -0.8274 | 5.0000 | 0.6814 | 0.9955 | 0.4410 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 7523.065 | uM | 15.65140 | 27.53810 | -0.9775 | -0.9786 | 1.9190 | 0.7791 | 0.9986 | 0.7668 | |
| MX1 | Unknown | Unknown | Triciribine | AKT | AKT | 7523.074 | uM | 0.03756 | 0.58390 | -0.8018 | -1.0000 | 0.4004 | 0.6722 | 0.9454 | 0.8505 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 12220.143 | uM | 16.61280 | 137.74590 | -0.9997 | -1.0000 | 0.5194 | 0.8265 | 0.8979 | 0.4532 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 10644.143 | uM | 355.22210 | 734.46760 | -0.9986 | -1.0000 | 1.5124 | 0.6015 | 0.9444 | 0.6221 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 10874.143 | uM | 659.99370 | 1000.00000 | -0.9925 | -0.8356 | 2.3645 | 0.3630 | 0.9849 | 0.7639 | |
| MX1 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7523.065 | uM | 85.53840 | 217.5980 | -0.9664 | -0.9657 | 1.1518 | 0.6518 | 0.9960 | 0.7668 | |
| MX1 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 10644.139 | uM | 0.59123 | 1.02640 | -0.9667 | -0.9881 | 1.9773 | 0.8155 | 0.9858 | 0.6077 | |
| MX1 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 10874.151 | uM | 0.39810 | 0.48080 | -0.8735 | -0.7817 | 4.9873 | 0.7696 | 0.9958 | 0.7476 | |
| MX1 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12220.157 | uM | 0.78424 | 0.95931 | -0.8685 | -0.8693 | 5.0000 | 0.7073 | 0.9972 | 0.3325 | |
| MX1 | Unknown | Unknown | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14278.189 | uM | 0.71917 | 1.01730 | -0.9902 | -0.9903 | 3.1493 | 0.7164 | 0.9850 | 0.7296 | |
| MX1 | Unknown | Unknown | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14649.189 | uM | 0.70080 | 0.92660 | -0.9986 | -0.9984 | 3.9295 | 0.6674 | 0.9968 | 0.5692 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 10874.15 | uM | 0.48692 | 1.34650 | 0.1577 | -0.1988 | 0.3291 | 0.3828 | 0.8488 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 10644.138 | uM | 0.42739 | 0.67816 | -0.9994 | -0.7754 | 2.0282 | 0.7559 | 0.9401 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 12220.16 | uM | 0.55140 | 0.86309 | -0.7759 | -0.6390 | 1.8375 | 0.5614 | 0.9888 | 0.4410 | |
| SK-BR-3 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7914.016 | uM | inf | 1000.00000 | 0.6091 | 0.1558 | 0.1923 | 0.1631 | 0.7877 | 1.6240 | ||
| SK-BR-3 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7912.016 | uM | 2.24250 | 0.70769 | 0.2656 | 0.2054 | 0.4587 | 0.3518 | 0.9448 | 0.4337 | ||
| SK-BR-3 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9759.019 | uM | 43.44110 | 92.81930 | -0.4154 | -1.0000 | 1.4470 | 0.1702 | 0.9813 | 1.3677 | ||
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 10127.037 | uM | 0.01916 | 0.02958 | -0.4757 | -0.1437 | 0.5815 | 0.7611 | 0.6487 | 0.7262 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9759.037 | uM | 0.04238 | 0.11134 | -0.6105 | -0.3754 | 0.5798 | 0.6842 | 0.9183 | 1.2944 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9760.037 | uM | 0.05110 | 0.46472 | -0.7818 | -0.7942 | 0.4308 | 0.7388 | 0.9507 | 0.9398 |