Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7529.09 | uM | 0.33528 | 92.35460 | -0.0364 | -1.0000 | 0.1955 | 0.4723 | 0.6856 | 0.4538 | |
| SUM1315MO2 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7528.091 | uM | 8.38320 | 144.72550 | 0.0444 | -1.0000 | 0.3857 | 0.2376 | 0.9011 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 10381.092 | uM | 19.61830 | 284.84140 | 0.3667 | -1.0000 | 0.4106 | 0.1427 | 0.9356 | 1.4137 | |
| SUM1315MO2 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 9044.091 | uM | 6.14760 | 85.37030 | 0.0264 | -1.0000 | 0.4176 | 0.2321 | 0.9590 | 0.6432 | |
| SUM1315MO2 | TNBC | Basal B | Etoposide | TOP2 | TOP | 9044.074 | uM | 0.14874 | 0.57237 | -0.8205 | -0.7290 | 0.6674 | 0.8246 | 0.9586 | 0.6607 | |
| SUM1315MO2 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7528.074 | uM | 0.45241 | 3.38780 | -0.6798 | -0.8278 | 0.4851 | 0.6555 | 0.9682 | 1.0143 | |
| SUM1315MO2 | TNBC | Basal B | Everolimus | MTOR | MTOR | 12428.164 | uM | 0.44818 | 6.51110 | -0.9897 | -1.0000 | 0.4105 | 0.5040 | 0.7797 | 0.8332 | |
| SUM1315MO2 | TNBC | Basal B | Everolimus | MTOR | MTOR | 10875.156 | uM | 0.08047 | 2.12030 | -1.0000 | -1.0000 | 0.3358 | 0.6358 | 0.8196 | 0.4392 | |
| SUM1315MO2 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7528.084 | uM | 0.41330 | 0.86388 | -0.9745 | -1.0000 | 1.4901 | 0.5789 | 0.9968 | 1.0247 | |
| SUM1315MO2 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 9044.084 | uM | 0.42073 | 0.52412 | -0.9998 | -1.0000 | 5.0000 | 0.6077 | 0.9987 | 0.4769 | |
| SUM1315MO2 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 10875.149 | uM | 13.45520 | 39.12590 | 0.0664 | -1.0000 | 1.0292 | 0.1281 | 0.9415 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 12428.166 | uM | 23.54840 | 23.91770 | 0.1484 | -0.0092 | 1.1773 | 0.1309 | 0.9451 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12428.167 | uM | 116.70050 | 998.9280 | 0.5788 | -0.7604 | 0.4306 | 0.0955 | 0.9109 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10875.154 | uM | 32.91020 | 9.61220 | 0.4999 | 0.4988 | 4.8953 | 0.0149 | 0.9436 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9797.019 | uM | 0.32507 | 1.57910 | -0.8809 | -1.0000 | 0.6951 | 0.5248 | 0.9594 | 0.4912 | |
| SUM1315MO2 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7529.016 | uM | 4.92220 | 27.16080 | -0.0638 | -1.0000 | 0.6432 | 0.2152 | 0.9605 | 0.5847 | |
| SUM1315MO2 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9797.012 | uM | 0.00490 | 0.00788 | -0.5647 | -0.5372 | 1.5343 | 1.1171 | 0.9868 | 0.4792 | |
| SUM1315MO2 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 10139.012 | uM | 0.06192 | 0.07685 | -0.1379 | -0.1873 | 1.4722 | 0.6549 | 0.9926 | 0.8556 | |
| SUM1315MO2 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9797.011 | uM | 0.07699 | 5.79710 | -0.4438 | -1.0000 | 0.2542 | 0.6732 | 0.9193 | 0.5004 | |
| SUM1315MO2 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 12428.169 | uM | 10.22690 | 8.44450 | 0.2193 | 0.0693 | 0.7792 | 0.1895 | 0.9241 | 0.7851 | ||
| SUM1315MO2 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 10875.15 | uM | 4.09610 | 11.30940 | -0.1016 | -0.5895 | 0.7669 | 0.2116 | 0.9744 | 0.8527 | ||
| SUM1315MO2 | TNBC | Basal B | GSK1070916 | AURK | AURK | 10139.001 | uM | 1.52610 | 5.13290 | -0.7348 | -1.0000 | 0.9057 | 0.3315 | 0.9948 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9797.001 | uM | 0.93105 | 2.25530 | -0.9738 | -1.0000 | 1.2418 | 0.4123 | 0.9950 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7529.09 | uM | inf | inf | 0.1997 | 0.1997 | 0.0000 | 0.5313 | 0.5381 | 0.4538 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 9044.098 | uM | 1.1170 | 0.91442 | -0.5477 | 0.1026 | 1.1475 | 0.3428 | 0.5871 | 0.8807 |