Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7528.091 | uM | 5.91580 | 6.44980 | -0.9872 | -0.2702 | 5.0000 | 0.4120 | 0.6082 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 10381.092 | uM | inf | 0.14239 | 0.6644 | 0.6861 | 1.9110 | 0.1694 | 0.8916 | 1.4137 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 9044.071 | uM | 5.37940 | 7.340 | -0.9986 | -1.0000 | 3.5352 | 0.4850 | 0.9489 | 0.6310 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7528.098 | uM | inf | 0.25981 | 0.6261 | 0.6514 | 1.1265 | 0.1323 | 0.9607 | 0.9717 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 9044.091 | uM | inf | 0.19893 | 0.5371 | 0.5475 | 4.9999 | 0.2111 | 0.9825 | 0.6432 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7528.071 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 10139.001 | uM | 0.02135 | 0.02889 | -0.8738 | -0.5837 | 2.5606 | 0.8536 | 0.9771 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9797.001 | uM | 0.02360 | 0.02841 | -0.8237 | -0.7651 | 5.0000 | 1.0103 | 0.9859 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 10139.001 | uM | 0.02038 | 0.02373 | -0.2141 | -0.2588 | 2.7392 | 0.7222 | 0.9857 | 0.7336 | |
| SUM1315MO2 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9797.001 | uM | 0.04247 | 0.04995 | -0.7351 | -0.6254 | 5.0000 | 0.8257 | 0.9905 | 0.6012 | |
| SUM1315MO2 | TNBC | Basal B | Ibandronate | FDPS | 12428.143 | uM | 45.03170 | 49.71970 | -0.4598 | -0.3204 | 5.0000 | 0.3279 | 0.9836 | 0.7057 | ||
| SUM1315MO2 | TNBC | Basal B | Ibandronate | FDPS | 10875.143 | uM | 43.68790 | 48.32390 | -0.4067 | -0.3205 | 4.9112 | 0.3728 | 0.9896 | 0.8219 | ||
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10875.151 | uM | 0.16526 | 0.20236 | -0.1515 | -0.1151 | 1.0235 | 0.4430 | 0.9904 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 12428.157 | uM | 0.90538 | 0.48687 | 0.2408 | 0.2542 | 1.1444 | 0.2624 | 0.9955 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 10381.093 | uM | 1.79380 | 3.0520 | -0.9893 | -1.0000 | 2.0672 | 0.4814 | 0.9940 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7529.09 | uM | inf | inf | -0.8193 | -0.8193 | 0.0000 | 0.2798 | 0.5708 | 0.4538 | |
| SUM1315MO2 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 10381.092 | uM | 25.38850 | 37.33180 | -0.9329 | -0.9304 | 2.7262 | 0.3941 | 0.9960 | 1.4137 | |
| SUM1315MO2 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7528.091 | uM | 24.41330 | 33.8270 | -0.9921 | -0.9897 | 3.3475 | 0.4046 | 0.9963 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 9044.091 | uM | 22.17230 | 27.61230 | -0.9989 | -0.9977 | 5.0000 | 0.4073 | 0.9977 | 0.6432 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 9044.067 | uM | 0.01283 | 0.01597 | -1.0000 | -0.9908 | 4.9982 | 1.3236 | 0.7375 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7528.067 | uM | 0.03020 | 0.03608 | -0.9982 | -0.7162 | 5.0000 | 0.9009 | 0.9827 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 10381.095 | uM | 0.00685 | 0.07017 | -0.9657 | -0.8823 | 0.4369 | 0.8915 | 0.8938 | 1.2787 | |
| SUM1315MO2 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7528.095 | uM | 0.01017 | 0.01222 | -0.9950 | -0.5018 | 3.7922 | 0.8979 | 0.9229 | 0.8526 | |
| SUM1315MO2 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 9044.095 | uM | 0.00170 | 0.00249 | -0.9987 | -0.6544 | 2.1817 | 1.2201 | 0.9538 | 0.7214 | |
| SUM1315MO2 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 12428.168 | uM | 1.09410 | 1.28580 | -0.7574 | -0.6212 | 5.0000 | 0.6335 | 0.9757 | 0.7957 |