Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 10875.144 | uM | 0.71710 | 0.89002 | -0.7907 | -0.7631 | 4.2897 | 0.6952 | 0.9934 | 0.7785 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 10875.149 | uM | 21.03160 | 29.56310 | -0.1898 | -1.0000 | 3.2264 | 0.1565 | 0.7999 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 12428.166 | uM | 19.14470 | 54.07310 | 0.2378 | -1.0000 | 1.0581 | 0.0827 | 0.9279 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 9044.098 | uM | 14.0530 | 113.88450 | 0.4184 | -1.0000 | 0.5251 | 0.1110 | 0.8304 | 0.8807 | |
| SUM1315MO2 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7528.098 | uM | inf | 0.18408 | 0.7450 | 0.7547 | 1.4124 | 0.0787 | 0.9255 | 0.9717 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 12428.167 | uM | 0.30244 | 0.74256 | -0.8743 | -0.9050 | 1.1503 | 0.5677 | 0.9960 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | LBH589 | HDAC | HDAC | 10875.154 | uM | 0.18989 | 0.30284 | -0.9937 | -0.9660 | 2.3047 | 0.6828 | 0.9972 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12428.167 | uM | 0.05317 | 0.41497 | -0.9765 | -1.0000 | 0.5347 | 0.7021 | 0.9708 | 1.0169 | |
| SUM1315MO2 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10875.154 | uM | 0.03307 | 0.09533 | -0.9963 | -0.8668 | 0.9498 | 0.8165 | 0.9882 | 0.7163 | |
| SUM1315MO2 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7528.084 | uM | inf | inf | 0.8853 | 0.8853 | 0.0000 | 0.0300 | 0.4220 | 1.0247 | |
| SUM1315MO2 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 9044.084 | uM | inf | inf | 0.8434 | 0.8434 | 0.0000 | -0.0323 | 0.5296 | 0.4769 | |
| SUM1315MO2 | TNBC | Basal B | Methylglyoxal | 13197.184 | uM | 477.56670 | 843.97530 | -0.9998 | -0.9846 | 1.9113 | 0.6795 | 0.9941 | 0.5530 | |||
| SUM1315MO2 | TNBC | Basal B | Methylglyoxal | 13520.184 | uM | 567.6950 | 786.82260 | -0.9992 | -0.9966 | 3.3588 | 0.6425 | 0.9974 | 0.6738 | |||
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14281.189 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.8447 | 0.5712 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14281.189 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.8447 | 0.5712 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 10875.145 | uM | 0.10386 | 0.19799 | -0.9918 | -0.9954 | 1.6979 | 0.8831 | 0.9985 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 10875.145 | uM | 0.10386 | 0.19799 | -0.9918 | -0.9954 | 1.6979 | 0.8831 | 0.9985 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 12428.17 | uM | 0.12477 | 0.22218 | -0.9639 | -0.9614 | 1.8587 | 0.8733 | 0.9993 | 0.9724 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 12428.17 | uM | 0.12477 | 0.22218 | -0.9639 | -0.9614 | 1.8587 | 0.8733 | 0.9993 | 0.9724 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 10875.148 | uM | inf | inf | 0.9445 | 0.9445 | 0.0000 | 0.2592 | 0.0755 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 12428.135 | uM | 0.06237 | 0.1150 | -0.3745 | -0.3343 | 0.8368 | 0.6468 | 0.9917 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Nilotinib | ABL | nRTK | 10875.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0427 | -3.3446 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12428.17 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0450 | -2.6385 | 0.9724 | |
| SUM1315MO2 | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10875.152 | uM | 0.93379 | 1.83720 | -0.9966 | -1.0000 | 1.6234 | 0.7461 | 0.9886 | 0.7465 | |
| SUM1315MO2 | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 12428.152 | uM | 1.13290 | 1.65830 | -0.9802 | -0.9909 | 2.8676 | 0.7650 | 0.9912 | 0.8719 |