Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7919.016 | uM | inf | inf | 0.6576 | 0.6576 | 0.0000 | 0.0567 | 0.5253 | 3.5497 | ||
| SUM159PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7920.016 | uM | inf | 147.84710 | 0.8503 | 0.7670 | 4.7960 | -0.0230 | 0.6294 | 4.3230 | ||
| SUM159PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9042.016 | uM | inf | 2.5420 | 0.8028 | 0.7523 | 4.9987 | 0.0695 | 0.7154 | 2.8524 | ||
| SUM159PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7918.016 | uM | 75.36610 | 111.09270 | -0.5212 | -1.0000 | 2.8314 | 0.1653 | 0.9046 | 3.1190 | ||
| SUM159PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7919.04 | uM | 0.04167 | 0.05119 | -0.4725 | -0.2657 | 2.0719 | 0.7284 | 0.9791 | 3.7375 | |
| SUM159PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9042.05 | uM | 0.01234 | 0.0160 | -0.2937 | -0.2124 | 1.3656 | 0.8203 | 0.9834 | 3.1161 | |
| SUM159PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7920.05 | uM | 0.06950 | 0.07046 | -0.1466 | -0.0220 | 3.1217 | 0.5658 | 0.9871 | 4.1624 | |
| SUM159PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7918.037 | uM | 0.04235 | 0.04699 | -0.2412 | -0.1989 | 3.2195 | 0.7156 | 0.9877 | 2.8917 | |
| SUM159PT | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 11057.143 | uM | 117.49380 | 138.80550 | 0.0197 | -0.0551 | 0.6266 | 0.3060 | 0.9924 | 4.1426 | |
| SUM159PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 7918.017 | uM | 55.49690 | 51.00660 | -0.0611 | 0.0231 | 0.5595 | 0.4429 | 0.9278 | 3.1833 | |
| SUM159PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 7919.017 | uM | 68.19810 | 71.10910 | -0.0335 | -0.0155 | 0.7291 | 0.4298 | 0.9904 | 3.7958 | |
| SUM159PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 7920.13 | uM | 130.24210 | 83.00670 | 0.1415 | 0.1407 | 0.7336 | 0.3613 | 0.9971 | 4.3955 | |
| SUM159PT | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 11057.158 | uM | 3.9340 | 7.18480 | -0.7343 | -0.7885 | 1.5717 | 0.3293 | 0.9976 | 3.8594 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 7531.066 | uM | inf | inf | 1.0194 | 1.0194 | 0.0000 | -0.0256 | -1.3735 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 7918.016 | uM | inf | inf | 0.6825 | 0.6825 | 0.0000 | 0.1161 | 0.2905 | 3.1190 | |
| SUM159PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 9042.016 | uM | 12.53920 | 8.6790 | 0.2330 | 0.4206 | 5.0000 | 0.1638 | 0.8252 | 2.8524 | |
| SUM159PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 7919.016 | uM | 32.55880 | 79.83270 | -0.4465 | -1.0000 | 1.2249 | 0.1931 | 0.9895 | 3.5497 | |
| SUM159PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 7920.016 | uM | 25.90870 | 33.39040 | -0.2225 | -0.2898 | 1.8023 | 0.1605 | 0.9971 | 4.3230 | |
| SUM159PT | TNBC | Basal B | AS-252424 | PI3K | PI3K | 11057.158 | uM | inf | 3.06690 | 0.4735 | 0.5788 | 5.0000 | 0.0928 | 0.9104 | 3.8594 | |
| SUM159PT | TNBC | Basal B | AS-252424 | PI3K | PI3K | 10520.141 | uM | 10.8170 | 5.94660 | 0.3744 | 0.3678 | 2.2237 | 0.1320 | 0.950 | 3.6374 | |
| SUM159PT | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7531.073 | uM | 234.36780 | 162.60140 | 0.6820 | 0.3991 | 4.3786 | -0.0035 | 0.9044 | 3.4904 | |
| SUM159PT | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 11057.072 | uM | 240.88130 | 167.67830 | 0.6604 | 0.3171 | 2.7765 | 0.0050 | 0.9563 | 4.0230 | |
| SUM159PT | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10520.072 | uM | 49.21310 | 59.38050 | -0.5968 | -0.6159 | 4.2745 | 0.0997 | 0.9925 | 3.3637 | |
| SUM159PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14921.203 | uM | 0.00175 | 0.00299 | -0.7142 | -0.7255 | 1.6650 | 1.3482 | 0.9972 | 3.0799 | |
| SUM159PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14921.203 | uM | 0.00175 | 0.00299 | -0.7142 | -0.7255 | 1.6650 | 1.3482 | 0.9972 | 3.0799 |