Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7532.091 | uM | 13.00210 | 19.9110 | -0.9881 | -0.9968 | 2.5729 | 0.5005 | 0.9982 | 0.9414 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 7532.067 | uM | 0.09840 | 0.67187 | -0.9893 | -1.0000 | 0.5719 | 0.6496 | 0.9465 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7532.095 | uM | 0.00315 | 0.10647 | -0.9979 | -1.0000 | 0.3122 | 0.9528 | 0.8310 | 0.7413 | |
| SUM185PE | TNBC | Luminal | JNK-IN-5A | JNK | JNK | 12269.144 | uM | inf | inf | -0.2421 | -0.2421 | 0.0000 | 0.2687 | 0.5217 | 1.0241 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7532.098 | uM | inf | inf | 0.8747 | 0.8747 | 0.0000 | 0.1305 | 0.3737 | 0.6992 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 12269.154 | uM | 0.07923 | 0.19201 | -0.9328 | -0.9155 | 1.1756 | 0.7622 | 0.9993 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12269.154 | uM | 0.04492 | 0.47511 | -0.9659 | -1.0000 | 0.4658 | 0.7628 | 0.7945 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Mebendazole | 13140.174 | uM | 0.40247 | 0.41642 | -0.0809 | -0.0374 | 2.1152 | 0.4704 | 0.9571 | 0.5769 | |||
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 7532.084 | uM | inf | inf | 0.8047 | 0.8047 | 0.0000 | 0.0855 | 0.1512 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methylglyoxal | 13619.184 | uM | 665.77460 | 699.53910 | -0.6332 | -0.1403 | 5.0000 | 0.4759 | 0.5806 | 0.8825 | |||
| SUM185PE | TNBC | Luminal | MG-132 | Proteasome | Proteasome | 12269.145 | uM | 0.06331 | 0.08807 | -0.9924 | -0.8782 | 3.0716 | 0.9437 | 0.9880 | 0.4894 | |
| SUM185PE | TNBC | Luminal | MG-132 | Proteasome | Proteasome | 12269.145 | uM | 0.06331 | 0.08807 | -0.9924 | -0.8782 | 3.0716 | 0.9437 | 0.9880 | 0.4894 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 12269.135 | uM | 0.03219 | 1.2480 | -0.4560 | -0.8365 | 0.2688 | 0.6831 | 0.7744 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Nelfinavir | 13140.174 | uM | 5.14150 | 9.05190 | -0.8796 | -1.0000 | 1.9423 | 0.2983 | 0.9624 | 0.5769 | |||
| SUM185PE | TNBC | Luminal | Nilotinib | ABL | nRTK | 12269.145 | uM | inf | inf | -0.2047 | -0.2047 | 0.0000 | 0.3187 | 0.1533 | 0.4894 | |
| SUM185PE | TNBC | Luminal | NSC 663284 | CDC25 | CDC | 12269.152 | uM | 0.28492 | 0.80724 | -0.9909 | -1.0000 | 1.0549 | 0.8215 | 0.9829 | 0.8791 | |
| SUM185PE | TNBC | Luminal | NU6102 | CDK1/2 | CDK | 12269.147 | uM | inf | inf | -0.7298 | -0.7298 | 0.0000 | 0.5320 | 0.2531 | 0.8519 | |
| SUM185PE | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 7532.066 | uM | 24.1910 | 48.19870 | -0.2640 | -1.0000 | 1.5937 | 0.1621 | 0.9184 | 0.9011 | |
| SUM185PE | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 12269.147 | uM | 0.95156 | 11.57380 | -0.5955 | -1.0000 | 0.4397 | 0.4958 | 0.6152 | 0.8519 | |
| SUM185PE | TNBC | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10146.12 | uM | 38.30250 | 59.44580 | -0.9703 | -0.9779 | 2.4656 | 0.3989 | 0.9889 | 1.0341 | |
| SUM185PE | TNBC | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7921.011 | uM | 33.13270 | 44.30690 | -0.9812 | -0.9843 | 3.7441 | 0.4150 | 0.9918 | 0.6757 | |
| SUM185PE | TNBC | Luminal | Oxamflatin | HDAC | HDAC | 12269.147 | uM | 0.31755 | 1.27050 | -0.9871 | -1.0000 | 0.7924 | 0.6283 | 0.9894 | 0.8519 | |
| SUM185PE | TNBC | Luminal | PD 98059 | MEK | MAPK | 12269.152 | uM | inf | inf | 0.1019 | 0.1019 | 0.0000 | 0.1402 | 0.2810 | 0.8791 | |
| SUM185PE | TNBC | Luminal | PD184352 | MEK | MAPK | 12269.155 | uM | inf | inf | 0.4424 | 0.4424 | 0.0000 | 0.3571 | 0.2001 | 0.7969 | |
| SUM185PE | TNBC | Luminal | PD184352 | MEK | MAPK | 12269.155 | uM | inf | inf | 0.4424 | 0.4424 | 0.0000 | 0.3571 | 0.2001 | 0.7969 |