Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Disulfiram | Proteasome | Proteasome | 13140.174 | uM | 354.06040 | 1000.00000 | 0.5561 | -0.1568 | 0.2626 | 0.1318 | 0.5867 | 0.5769 | |
| SUM185PE | TNBC | Luminal | Docetaxel | TUBB | TUBB | 10146.002 | uM | inf | 0.01745 | 0.6289 | 0.5622 | 5.0000 | 0.2445 | 0.6138 | 0.9649 | |
| SUM185PE | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7921.002 | uM | 0.01572 | 0.01584 | 0.0138 | -0.0205 | 5.0000 | 0.5296 | 0.9755 | 0.7161 | |
| SUM185PE | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 10146.121 | uM | 0.29887 | 0.51632 | -0.9534 | -0.6247 | 1.4828 | 0.6114 | 0.9592 | 1.0246 | |
| SUM185PE | TNBC | Luminal | Epirubicin | TOP2 | TOP | 7921.017 | uM | 0.37333 | 0.58272 | -0.9985 | -0.7868 | 2.1230 | 0.7709 | 0.9806 | 0.8018 | |
| SUM185PE | TNBC | Luminal | Erlotinib | EGFR | ErbB | 7532.091 | uM | inf | 12.64350 | 0.6327 | 0.6321 | 3.8299 | 0.0179 | 0.9280 | 0.9414 | |
| SUM185PE | TNBC | Luminal | Etoposide | TOP2 | TOP | 7532.074 | uM | 4.58570 | 14.60410 | -0.2017 | -0.4299 | 0.5357 | 0.3681 | 0.9836 | 0.7728 | |
| SUM185PE | TNBC | Luminal | Everolimus | MTOR | MTOR | 12269.164 | uM | 4.14390 | 6.9690 | -0.6978 | -0.7338 | 1.7375 | 0.4199 | 0.7167 | 0.4042 | |
| SUM185PE | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 7532.084 | uM | 0.05116 | 0.11640 | -0.9983 | -1.0000 | 1.3363 | 0.9200 | 0.9941 | 0.7770 | |
| SUM185PE | TNBC | Luminal | FTase Inhibitor I | Ftase | MAPK | 12269.154 | uM | inf | inf | 0.0944 | 0.0944 | 0.0000 | 0.3950 | 0.0416 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Gefitinib | EGFR | ErbB | 10146.049 | uM | 9.58160 | 10.82830 | -0.3998 | -0.4057 | 4.8572 | 0.0782 | 0.9925 | 0.8861 | |
| SUM185PE | TNBC | Luminal | Gefitinib | EGFR | ErbB | 7921.016 | uM | 7.82350 | 9.3870 | -0.7304 | -0.7336 | 4.9568 | 0.1164 | 0.9954 | 0.6622 | |
| SUM185PE | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 7921.04 | uM | 0.01550 | 0.02132 | -0.6986 | -0.6280 | 2.5504 | 1.0663 | 0.9971 | 0.7738 | |
| SUM185PE | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 10146.049 | uM | 0.01746 | 0.02114 | -0.8575 | -0.8001 | 5.0000 | 1.1932 | 0.9977 | 0.8861 | |
| SUM185PE | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 10146.12 | uM | 0.20680 | 0.07407 | 0.1910 | 0.2819 | 0.8081 | 0.3742 | 0.9331 | 1.0341 | |
| SUM185PE | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 7921.011 | uM | 0.32773 | 0.14516 | 0.1578 | 0.2094 | 0.6665 | 0.4294 | 0.9454 | 0.6757 | |
| SUM185PE | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 12269.16 | uM | inf | inf | 0.1892 | 0.1892 | 0.0000 | 0.6667 | 0.2914 | 0.6567 | ||
| SUM185PE | TNBC | Luminal | GSK1070916 | AURK | AURK | 10146.001 | uM | 1.0110 | 2.21080 | -0.9960 | -1.0000 | 1.4042 | 0.3839 | 0.9935 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7532.091 | uM | 28.95110 | 41.95150 | -0.9860 | -1.0000 | 2.9620 | 0.2714 | 0.8451 | 0.9414 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7532.098 | uM | 2.29380 | 3.63270 | -0.9972 | -1.0000 | 2.3895 | 0.5839 | 0.9418 | 0.6992 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7532.071 | uM | 5.36210 | 7.35660 | -0.9947 | -1.0000 | 3.4739 | 0.5457 | 0.9452 | 0.8178 | |
| SUM185PE | TNBC | Luminal | GSK461364 | PLK1 | PLK | 10146.001 | uM | 1.76740 | 4.94340 | -0.9656 | -1.0000 | 1.0681 | 0.4153 | 0.8876 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 10146.001 | uM | 2.6670 | 8.09230 | -0.8800 | -1.0000 | 0.9898 | 0.3137 | 0.8896 | 0.7356 | |
| SUM185PE | TNBC | Luminal | Ibandronate | FDPS | 12269.143 | uM | 160.42990 | 196.12130 | -0.8638 | -0.8651 | 5.0000 | 0.4406 | 0.8751 | 0.3088 | ||
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 12269.157 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1012 | 0.1215 | 0.5397 |