Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7536.09 | uM | inf | inf | 0.4561 | 0.4561 | 0.0000 | 0.2955 | 0.4278 | 1.1257 | |
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7535.092 | uM | 4.99350 | 105.27110 | 0.1007 | -1.0000 | 0.3604 | 0.2420 | 0.8485 | 1.1267 | |
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7537.091 | uM | 28.06160 | 33.68310 | 0.4130 | -0.0340 | 0.3606 | 0.1825 | 0.9730 | 2.0227 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 7535.074 | uM | 0.7680 | 1.77280 | -0.8127 | -0.7914 | 1.1343 | 0.7541 | 0.9949 | 1.0507 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 7537.074 | uM | 1.34020 | 3.84820 | -0.5228 | -0.6098 | 0.7559 | 0.5759 | 0.9969 | 2.0080 | |
| SUM229PE | TNBC | - | Everolimus | MTOR | MTOR | 11058.156 | uM | 17.5140 | 27.36110 | -0.8063 | -1.0000 | 2.4626 | 0.2311 | 0.9561 | 1.9927 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 7537.084 | uM | 0.40339 | 0.56565 | -0.8695 | -0.8666 | 2.9742 | 0.5868 | 0.9991 | 1.8684 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 11058.149 | uM | 113.61470 | 998.910 | 0.6850 | -0.9807 | 0.4994 | 0.0676 | 0.8296 | 2.1834 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 11058.154 | uM | inf | inf | 0.7973 | 0.7973 | 0.0000 | 0.0599 | 0.3406 | 2.0897 | |
| SUM229PE | TNBC | - | Gefitinib | EGFR | ErbB | 7536.016 | uM | 5.35670 | 6.57570 | -0.8931 | -0.8937 | 4.9996 | 0.3861 | 0.8670 | 0.6413 | |
| SUM229PE | TNBC | - | Gefitinib | EGFR | ErbB | 9860.019 | uM | 7.39230 | 14.22470 | -0.6371 | -1.0000 | 1.6785 | 0.2353 | 0.9599 | 1.6927 | |
| SUM229PE | TNBC | - | Geldanamycin | HSP90 | HSP90 | 9860.012 | uM | 0.01197 | 0.01380 | -0.1744 | -0.1506 | 1.8528 | 0.7853 | 0.9974 | 1.7144 | |
| SUM229PE | TNBC | - | Gemcitabine | DNA replication | DNA replication | 9860.011 | uM | 0.13926 | 0.09413 | 0.1354 | 0.1900 | 1.2204 | 0.4395 | 0.9770 | 1.4618 | |
| SUM229PE | TNBC | - | Glycyl-H-1152 | ROCK2 | 11058.15 | uM | 7.67640 | 5.95940 | 0.2551 | 0.1076 | 0.9571 | 0.1467 | 0.9649 | 2.2684 | ||
| SUM229PE | TNBC | - | GSK1070916 | AURK | AURK | 9860.001 | uM | 0.74684 | 4.08710 | -0.8582 | -1.0000 | 0.6463 | 0.4010 | 0.9378 | 1.6119 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7536.09 | uM | 1.41040 | 1.44250 | -0.1485 | -0.0596 | 5.0000 | 0.4511 | 0.7353 | 1.1257 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7537.091 | uM | 0.80344 | 3.41010 | -0.8389 | -0.8757 | 0.7001 | 0.5314 | 0.9812 | 2.0227 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7535.092 | uM | 0.57156 | 1.34310 | -0.9514 | -0.8961 | 1.2018 | 0.6138 | 0.9831 | 1.1267 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7537.071 | uM | 0.64321 | 3.09880 | -0.8120 | -1.0000 | 0.6987 | 0.5906 | 0.9838 | 1.9607 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7535.098 | uM | 0.79863 | 1.97230 | -0.9658 | -0.9957 | 1.2120 | 0.5957 | 0.9865 | 1.0037 | |
| SUM229PE | TNBC | - | GSK1838705A | IGF1R | RTK | 7537.098 | uM | 0.55408 | 1.93350 | -0.7965 | -0.9343 | 0.8432 | 0.5524 | 0.9964 | 1.8887 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 9860.001 | uM | 0.01553 | 0.01497 | -0.2168 | 0.0836 | 4.9873 | 0.5183 | 0.9233 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 9860.001 | uM | 0.06371 | 0.25684 | -0.6640 | -0.5100 | 0.5043 | 0.5438 | 0.8760 | 1.6119 | |
| SUM229PE | TNBC | - | Ibandronate | FDPS | 11058.143 | uM | 81.08170 | 74.23080 | 0.0736 | 0.0415 | 0.9823 | 0.2245 | 0.9959 | 2.3374 | ||
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 11058.151 | uM | 1.50180 | 0.58814 | 0.3024 | 0.2328 | 0.6684 | 0.2705 | 0.9577 | 2.2617 |