Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7541.067 | uM | 15.23910 | 15.42490 | 0.0199 | -0.0090 | 1.4644 | 0.2301 | 0.9623 | 1.4459 | |
| SUM52PE | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 11852.144 | uM | inf | 25.94550 | 0.6006 | 0.6001 | 4.8149 | 0.0038 | 0.9292 | 1.2876 | |
| SUM52PE | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10695.144 | uM | 20.92760 | 25.58980 | -0.8646 | -0.8666 | 4.9994 | 0.1286 | 0.9946 | 1.2333 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 11852.155 | uM | 13.44280 | 3.97070 | 0.4002 | 0.3713 | 1.1129 | 0.1293 | 0.9810 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 10695.146 | uM | 11.59760 | 6.51090 | 0.3182 | 0.2851 | 1.4625 | 0.0955 | 0.9832 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10695.153 | uM | 1.37770 | 5.1960 | -0.8869 | -1.0000 | 0.8276 | 0.4248 | 0.9818 | 1.4050 | |
| SUM52PE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 11852.158 | uM | 1.58830 | 5.7660 | -0.9078 | -1.0000 | 0.8521 | 0.3847 | 0.9842 | 1.3172 | |
| SUM52PE | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7540.068 | uM | 0.00006 | 0.02391 | -0.9666 | -1.0000 | 0.1851 | 1.1952 | 0.7788 | 0.9679 | |
| SUM52PE | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7541.069 | uM | 0.00929 | 0.41233 | -0.4334 | -0.6820 | 0.2268 | 0.6661 | 0.8344 | 1.5197 | |
| SUM52PE | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7541.084 | uM | 1.81090 | 6.40210 | -0.6430 | -0.5390 | 0.5792 | 0.5861 | 0.9414 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7541.067 | uM | 1.20340 | 3.27480 | -0.9936 | -1.0000 | 1.0974 | 0.6535 | 0.9933 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Taxol | TUBB | TUBB | 12969.002 | uM | 0.00472 | 0.0040 | 0.1005 | 0.1359 | 1.9204 | 0.6282 | 0.8872 | 1.0653 | |
| SUM52PE | HR+ | Luminal | Taxol | TUBB | TUBB | 9889.002 | uM | 0.00261 | 0.00339 | -0.4047 | -0.3473 | 2.0228 | 0.9632 | 0.9952 | 1.1879 | |
| SUM52PE | HR+ | Luminal | Taxol | TUBB | TUBB | 9878.002 | uM | 0.00699 | 0.00894 | -0.4289 | -0.3904 | 2.3439 | 0.8797 | 0.9958 | 1.3437 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 11852.159 | uM | 0.36432 | 0.50909 | -0.5787 | -0.4125 | 1.7981 | 0.4497 | 0.9793 | 1.3247 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10695.152 | uM | 0.39667 | 0.56843 | -0.6108 | -0.5773 | 2.1334 | 0.4949 | 0.9984 | 1.2495 | |
| SUM52PE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10695.148 | uM | 14.9730 | 46.8350 | -0.1802 | -1.0000 | 0.9634 | 0.1796 | 0.9788 | 1.5078 | |
| SUM52PE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11852.135 | uM | 26.48710 | 26.44040 | 0.0047 | 0.0044 | 5.0000 | 0.0852 | 0.9843 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10695.144 | uM | 0.00009 | 0.11643 | -0.9723 | -1.0000 | 0.1538 | 1.0263 | 0.6812 | 1.2333 | |
| SUM52PE | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 11852.144 | uM | 0.00436 | 0.03753 | -0.3336 | -0.3874 | 0.2665 | 0.8256 | 0.8074 | 1.2876 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 7540.078 | uM | 0.00839 | 0.02466 | -0.7407 | -0.7887 | 0.8780 | 1.1756 | 0.9868 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10695.15 | uM | 0.41910 | 0.92056 | -0.4728 | -0.5248 | 0.9120 | 0.4451 | 0.9829 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11852.16 | uM | 0.34294 | 0.72463 | -0.3662 | -0.4251 | 0.8224 | 0.4315 | 0.9931 | 1.2383 | |
| SUM52PE | HR+ | Luminal | TPCA-1 | IKK | NFKB | 7539.093 | uM | 0.47224 | 0.74636 | 0.0991 | -0.0997 | 0.3971 | 0.4229 | 0.8010 | 1.5919 | |
| SUM52PE | HR+ | Luminal | Trametinib | MEK | MAPK | 7540.05 | uM | 0.12639 | 0.01882 | 0.2120 | 0.3321 | 0.5730 | 0.3383 | 0.8729 | 0.6835 |