Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | IKK16 | IKK | NFKB | 7535.1 | uM | 0.90842 | 1.74550 | -0.9920 | -1.0000 | 1.6821 | 0.6060 | 0.9931 | 0.8740 | |
| SUM229PE | TNBC | - | Imatinib | ABL/KIT/PDGFR | nRTK | 7536.09 | uM | 5.28840 | 5.97590 | -0.8266 | -0.2285 | 3.0803 | 0.5234 | 0.7358 | 1.1257 | |
| SUM229PE | TNBC | - | Imatinib | ABL/KIT/PDGFR | nRTK | 7535.092 | uM | 4.79920 | 11.29430 | -0.9795 | -1.0000 | 1.2837 | 0.6892 | 0.9769 | 1.1267 | |
| SUM229PE | TNBC | - | Imatinib | ABL/KIT/PDGFR | nRTK | 7537.091 | uM | 22.32830 | 35.37410 | -0.8881 | -0.8842 | 2.2131 | 0.4003 | 0.9990 | 2.0227 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 7537.067 | uM | 0.04217 | 0.43153 | -0.8917 | -1.0000 | 0.4724 | 0.6911 | 0.9357 | 1.9773 | |
| SUM229PE | TNBC | - | Ixabepilone | TUBB | TUBB | 7537.095 | uM | 0.00129 | 0.16649 | -0.8426 | -1.0000 | 0.2259 | 0.9025 | 0.8089 | 1.9867 | |
| SUM229PE | TNBC | - | Ixabepilone | TUBB | TUBB | 7535.095 | uM | 0.00741 | 0.02531 | -0.9977 | -0.8822 | 0.8277 | 1.0671 | 0.9688 | 0.8131 | |
| SUM229PE | TNBC | - | JNK-IN-5A | JNK | JNK | 11058.144 | uM | 5.57780 | 0.74698 | 0.2152 | 0.3693 | 0.6674 | 0.2310 | 0.8560 | 2.1171 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 11058.149 | uM | 29.3710 | 33.44390 | 0.2808 | -0.4533 | 4.9690 | 0.0465 | 0.9754 | 2.1834 | |
| SUM229PE | TNBC | - | Lapatinib | EGFR/HER2 | ErbB | 7535.098 | uM | inf | inf | 0.8443 | 0.8443 | 0.0000 | 0.0793 | -0.0135 | 1.0037 | |
| SUM229PE | TNBC | - | Lapatinib | EGFR/HER2 | ErbB | 7537.098 | uM | 20.68970 | 69.47480 | 0.5343 | -0.3982 | 0.4836 | 0.1040 | 0.9689 | 1.8887 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 11058.154 | uM | 0.34314 | 0.57547 | -0.6155 | -0.5953 | 1.5166 | 0.4957 | 0.9965 | 2.0897 | |
| SUM229PE | TNBC | - | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11058.154 | uM | 0.45129 | 1.84470 | -0.5592 | -0.7539 | 0.6530 | 0.4208 | 0.9917 | 2.0897 | |
| SUM229PE | TNBC | - | Mebendazole | 13062.174 | uM | 21.85180 | 649.20950 | 0.2977 | -1.0000 | 0.3239 | 0.1848 | 0.9092 | 1.6688 | |||
| SUM229PE | TNBC | - | Mebendazole | 13009.174 | uM | 0.27704 | 0.26351 | -0.0137 | 0.0324 | 1.3375 | 0.4514 | 0.9639 | 1.4104 | |||
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 7537.084 | uM | inf | 0.14909 | 0.6713 | 0.6999 | 4.9991 | 0.1845 | 0.9423 | 1.8684 | |
| SUM229PE | TNBC | - | Methylglyoxal | 13062.184 | uM | 489.42160 | 1000.00000 | -0.8881 | -0.8545 | 1.3948 | 0.6065 | 0.9903 | 1.7868 | |||
| SUM229PE | TNBC | - | Methylglyoxal | 13201.184 | uM | 535.45630 | 662.02810 | -0.9518 | -0.9445 | 4.9999 | 0.6502 | 0.9991 | 1.3314 | |||
| SUM229PE | TNBC | - | MG-132 | Proteasome | Proteasome | 14224.189 | uM | 0.15754 | 0.16136 | -0.4163 | -0.0638 | 5.0000 | 0.5693 | 0.5763 | 1.8849 | |
| SUM229PE | TNBC | - | MG-132 | Proteasome | Proteasome | 14224.189 | uM | 0.15754 | 0.16136 | -0.4163 | -0.0638 | 5.0000 | 0.5693 | 0.5763 | 1.8849 | |
| SUM229PE | TNBC | - | MG-132 | Proteasome | Proteasome | 11058.145 | uM | 0.11057 | 0.14934 | -0.6137 | -0.5960 | 2.6106 | 0.7457 | 0.9989 | 2.2039 | |
| SUM229PE | TNBC | - | MG-132 | Proteasome | Proteasome | 11058.145 | uM | 0.11057 | 0.14934 | -0.6137 | -0.5960 | 2.6106 | 0.7457 | 0.9989 | 2.2039 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 11058.135 | uM | 0.29089 | 0.27058 | -0.0109 | 0.0494 | 1.4364 | 0.4085 | 0.9879 | 2.1492 | |
| SUM229PE | TNBC | - | Nelfinavir | 13062.174 | uM | inf | inf | 0.8787 | 0.8787 | 0.0000 | 0.0341 | 0.4048 | 1.6688 | |||
| SUM229PE | TNBC | - | Nelfinavir | 13009.174 | uM | 6.26470 | 9.98760 | -0.8378 | -0.9544 | 2.2893 | 0.2181 | 0.9953 | 1.4104 |