Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7532.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0445 | -2.0993 | 0.7413 | |
| SUM185PE | TNBC | Luminal | PS-1145 | IKK | NFKB | 7532.065 | uM | 6520.15750 | 281.1310 | 0.5765 | 0.4394 | 0.6710 | 0.0905 | 0.7823 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 7532.067 | uM | 17.70060 | 19.60730 | -0.0588 | -0.0901 | 1.6188 | 0.2070 | 0.9795 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ribavirin | 15332.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0259 | 0.0000 | 0.8413 | |||
| SUM185PE | TNBC | Luminal | SB-3CT | MMP2/9 | MMP | 12269.144 | uM | 14.82210 | 212.99030 | 0.1579 | -1.0000 | 0.4122 | 0.2400 | 0.5753 | 1.0241 | |
| SUM185PE | TNBC | Luminal | Selumetinib | MEK | MAPK | 12269.155 | uM | inf | inf | 1.0402 | 1.0402 | 0.0000 | -0.0494 | -252.5060 | 0.7969 | |
| SUM185PE | TNBC | Luminal | Sigma A6730 | AKT | AKT | 12269.165 | uM | 0.53724 | 1.58370 | -0.9982 | -1.0000 | 1.0162 | 0.5697 | 0.9773 | 0.6001 | |
| SUM185PE | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7532.069 | uM | 0.06179 | 2.90620 | -0.8248 | -1.0000 | 0.2853 | 0.5683 | 0.7543 | 0.8631 | |
| SUM185PE | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7532.084 | uM | 1.81290 | 4.46610 | -0.8090 | -0.4765 | 0.7424 | 0.6219 | 0.7754 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7532.067 | uM | 0.94581 | 3.07770 | -0.9914 | -1.0000 | 0.9311 | 0.7010 | 0.9750 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Taxol | TUBB | TUBB | 10146.002 | uM | inf | inf | 0.3184 | 0.3184 | 0.0000 | 0.3433 | 0.4907 | 0.9649 | |
| SUM185PE | TNBC | Luminal | Taxol | TUBB | TUBB | 7921.002 | uM | 0.02121 | 0.02350 | -0.1769 | -0.1160 | 2.0410 | 0.6375 | 0.9937 | 0.7161 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 12269.152 | uM | 0.12910 | 0.32611 | -0.7774 | -0.7292 | 0.9707 | 0.5855 | 0.9825 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12269.135 | uM | 18.99140 | 73.06390 | -0.2667 | -1.0000 | 0.8154 | 0.2470 | 0.9230 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Temsirolimus | MTOR | MTOR | 12269.144 | uM | inf | inf | -0.9706 | -0.9706 | 0.0000 | 0.9064 | 0.5515 | 1.0241 | |
| SUM185PE | TNBC | Luminal | Topotecan | TOP1 | TOP | 10146.121 | uM | 0.05659 | 0.21442 | -0.5116 | -0.6110 | 0.5994 | 0.7900 | 0.8622 | 1.0246 | |
| SUM185PE | TNBC | Luminal | Torkinib | 15332.211 | uM | 1.12310 | 1.43350 | -0.1839 | -0.1860 | 1.2957 | 0.3381 | 0.9687 | 0.8413 | |||
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12269.16 | uM | inf | inf | -0.9827 | -0.9827 | 0.0000 | 0.7329 | 0.4219 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 7921.036 | uM | 12.09070 | 0.66507 | 0.4059 | 0.3751 | 0.4782 | 0.1614 | 0.8483 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trastuzumab | HER2 | ErbB | 10146.124 | uM | inf | inf | 0.8709 | 0.8709 | 0.0000 | -0.0388 | 0.2980 | 0.9296 | |
| SUM185PE | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7532.065 | uM | 15.77380 | 28.95350 | -0.9978 | -1.0000 | 1.8089 | 0.8125 | 0.9994 | 0.6453 | |
| SUM185PE | TNBC | Luminal | Triciribine | AKT | AKT | 7532.074 | uM | 0.12234 | 0.38450 | -0.4383 | -0.4931 | 0.5992 | 0.5244 | 0.9780 | 0.7728 | |
| SUM185PE | TNBC | Luminal | Valproic acid | HDAC | HDAC | 12269.143 | uM | 831.78640 | 1000.00000 | -0.9728 | -0.7558 | 5.0000 | 0.3220 | 0.9529 | 0.3088 | |
| SUM185PE | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7921.042 | uM | 0.00926 | 0.01132 | -0.9855 | -0.4974 | 3.4382 | 0.9396 | 0.8930 | 0.6355 | |
| SUM185PE | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7532.065 | uM | 38.29490 | 119.5990 | -0.9963 | -1.0000 | 0.9647 | 0.7993 | 0.9966 | 0.6453 |