Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7531.074 | uM | 0.05822 | 0.12916 | -0.7953 | -0.8182 | 1.2165 | 1.0082 | 0.9979 | 3.2488 | |
| SUM159PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7531.074 | uM | 0.05822 | 0.12916 | -0.7953 | -0.8182 | 1.2165 | 1.0082 | 0.9979 | 3.2488 | |
| SUM159PT | TNBC | Basal B | Bosutinib | Src | nRTK | 11057.145 | uM | 3.35180 | 5.16640 | -0.6605 | -0.6816 | 1.9876 | 0.4174 | 0.9853 | 3.8266 | |
| SUM159PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7918.011 | uM | 37.40730 | 46.20860 | -0.5034 | -0.4737 | 3.1542 | 0.3841 | 0.9883 | 2.8897 | |
| SUM159PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9844.021 | uM | 27.29220 | 38.00460 | -0.5814 | -0.5674 | 2.2904 | 0.4136 | 0.9976 | 2.4889 | |
| SUM159PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7920.075 | uM | 70.40610 | 84.95560 | -0.2887 | -0.2931 | 2.4562 | 0.2851 | 0.9991 | 4.5785 | |
| SUM159PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7919.011 | uM | 36.27030 | 48.14520 | -0.4327 | -0.4469 | 2.2545 | 0.3726 | 0.9997 | 3.6508 | |
| SUM159PT | TNBC | Basal B | Celecoxib | COX2 | COX | 10520.136 | uM | inf | inf | 0.9370 | 0.9370 | 0.0000 | 0.0170 | 0.1158 | 4.0331 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9042.018 | uM | inf | inf | 0.7732 | 0.7732 | 0.0000 | 0.1379 | 0.0911 | 3.2484 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7918.018 | uM | inf | inf | 0.9278 | 0.9278 | 0.0000 | 0.0321 | 0.1456 | 3.0213 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7920.018 | uM | inf | inf | 0.9492 | 0.9492 | 0.0000 | 0.0108 | 0.4781 | 4.3723 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7919.042 | uM | inf | 4.91520 | 0.9535 | 0.7757 | 0.6890 | 0.0060 | 0.8149 | 3.7203 | |
| SUM159PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9042.018 | uM | 346.46610 | 1000.00000 | -0.7773 | -0.8388 | 0.9292 | 0.3485 | 0.7508 | 3.2484 | ||
| SUM159PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9844.034 | uM | 276.70090 | 1000.00000 | -0.6118 | -0.7858 | 0.7352 | 0.3138 | 0.8126 | 2.2318 | ||
| SUM159PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7920.018 | uM | 640.18180 | 1000.00000 | -0.3159 | -0.3141 | 1.0931 | 0.2051 | 0.8249 | 4.3723 | ||
| SUM159PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7918.018 | uM | 113.81230 | 620.84460 | -0.5727 | -1.0000 | 0.6476 | 0.4014 | 0.9793 | 3.0213 | ||
| SUM159PT | TNBC | Basal B | Chk2 inhibitor II | CHK2 | CHK | 10520.14 | uM | inf | inf | 0.9128 | 0.9128 | 0.0000 | 0.0580 | 0.4027 | 3.7031 | |
| SUM159PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7918.017 | uM | 2.3120 | 11.19160 | -0.6044 | -0.8254 | 0.6181 | 0.4941 | 0.9809 | 3.1833 | |
| SUM159PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7919.017 | uM | 3.87590 | 6.04680 | -0.5573 | -0.4798 | 1.5126 | 0.4101 | 0.9928 | 3.7958 | |
| SUM159PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9844.021 | uM | 4.72050 | 8.71030 | -0.6246 | -0.5870 | 1.2677 | 0.3936 | 0.9938 | 2.4889 | |
| SUM159PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7920.13 | uM | 6.34610 | 9.52020 | -0.3684 | -0.3475 | 1.3011 | 0.3473 | 0.9952 | 4.3955 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9844.034 | uM | 3.88270 | 7.81390 | -0.4933 | -0.5965 | 1.1228 | 0.2832 | 0.9823 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7919.043 | uM | inf | 8.52240 | 0.6665 | 0.6652 | 2.5590 | 0.0488 | 0.9824 | 3.1744 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7918.007 | uM | 5.45080 | 8.01590 | -0.4277 | -0.4612 | 1.6947 | 0.2431 | 0.9949 | 2.9756 | |
| SUM159PT | TNBC | Basal B | Dactolisib | PI3K | PI3K | 11057.155 | uM | 0.06495 | 0.04736 | 0.1337 | 0.1744 | 1.3579 | 0.4633 | 0.9158 | 4.1614 |