Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13054.176 | uM | inf | inf | 0.9156 | 0.9156 | 0.0000 | 0.0190 | 0.3141 | 3.2146 | |
| SUM159PT | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13004.176 | uM | inf | 0.07582 | 0.9422 | 0.9462 | 0.8257 | 0.0105 | 0.5981 | 3.4179 | |
| SUM159PT | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13004.174 | uM | 1.95710 | 8.34490 | -0.8406 | -1.0000 | 0.7576 | 0.4341 | 0.8919 | 3.2757 | |
| SUM159PT | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13054.174 | uM | 0.14850 | 0.11072 | 0.4517 | 0.3848 | 5.0000 | 0.3095 | 0.8992 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7918.002 | uM | 0.00859 | 0.01002 | -0.0723 | -0.1259 | 1.4569 | 0.5958 | 0.9893 | 2.8377 | |
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 13004.002 | uM | 0.00146 | 0.00162 | -0.0693 | -0.0843 | 1.4851 | 0.7365 | 0.9961 | 3.1387 | |
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 13054.002 | uM | 0.00080 | 0.00091 | -0.1135 | -0.1113 | 1.6186 | 0.8007 | 0.9974 | 3.0574 | |
| SUM159PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9844.002 | uM | 0.0030 | 0.00332 | -0.1446 | -0.1743 | 2.9893 | 0.7264 | 0.9975 | 2.4608 | |
| SUM159PT | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9844.034 | uM | 0.09713 | 0.13291 | -0.6988 | -0.3868 | 1.8270 | 0.6763 | 0.9549 | 2.2318 | |
| SUM159PT | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7918.007 | uM | 0.10887 | 0.25075 | -0.6820 | -0.4974 | 0.8278 | 0.6724 | 0.9603 | 2.9756 | |
| SUM159PT | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7919.043 | uM | 0.64675 | 1.14680 | -0.2526 | -0.2895 | 0.7976 | 0.4315 | 0.9888 | 3.1744 | |
| SUM159PT | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7918.017 | uM | 0.16444 | 0.17142 | -0.3793 | -0.0359 | 1.6707 | 0.5924 | 0.7989 | 3.1833 | |
| SUM159PT | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7919.017 | uM | 0.18887 | 0.25521 | -0.6913 | -0.3973 | 1.9428 | 0.6797 | 0.9592 | 3.7958 | |
| SUM159PT | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7531.091 | uM | inf | 6.98870 | 0.5380 | 0.5311 | 1.9151 | 0.0762 | 0.9866 | 3.3140 | |
| SUM159PT | TNBC | Basal B | Etoposide | TOP2 | TOP | 7531.074 | uM | 1.76780 | 7.65810 | -0.6168 | -0.7182 | 0.6074 | 0.5028 | 0.990 | 3.2488 | |
| SUM159PT | TNBC | Basal B | Everolimus | MTOR | MTOR | 11057.156 | uM | 14.08440 | 25.29270 | -0.7626 | -1.0000 | 1.8765 | 0.3194 | 0.8382 | 3.5568 | |
| SUM159PT | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7531.085 | uM | 0.68336 | 1.24990 | -0.7688 | -0.8239 | 1.6128 | 0.4546 | 0.9968 | 3.5188 | |
| SUM159PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 10520.137 | uM | inf | inf | 0.8283 | 0.8283 | 0.0000 | 0.0670 | 0.5419 | 3.7823 | |
| SUM159PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 11057.149 | uM | 138.43220 | 340.81150 | 0.7733 | -0.4654 | 0.7303 | 0.0467 | 0.7551 | 4.1019 | |
| SUM159PT | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10520.142 | uM | 13.24080 | 17.6640 | -0.7591 | -0.9325 | 3.6518 | 0.1331 | 0.9929 | 3.1766 | |
| SUM159PT | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 11057.154 | uM | 8.08130 | 9.68710 | -0.5505 | -0.5595 | 4.1437 | 0.1410 | 0.9976 | 3.8498 | |
| SUM159PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9042.016 | uM | 9.91910 | 9.6060 | 0.0942 | 0.0337 | 2.1769 | 0.0899 | 0.9684 | 2.8524 | |
| SUM159PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7920.016 | uM | 27.5070 | 43.54760 | 0.3380 | -0.8378 | 2.1423 | 0.0270 | 0.9777 | 4.3230 | |
| SUM159PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7918.016 | uM | 7.33990 | 16.57960 | -0.4571 | -1.0000 | 1.3483 | 0.1645 | 0.9898 | 3.1190 | |
| SUM159PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7919.016 | uM | 12.87620 | 24.64390 | -0.2507 | -1.0000 | 1.6924 | 0.1133 | 0.9971 | 3.5497 |