Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | XRP44X | ELK3 | MAPK | 12269.157 | uM | 0.01870 | 0.01625 | 0.1418 | 0.2521 | 4.9999 | 0.4915 | 0.6464 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 12269.16 | uM | 29.68990 | 62.01540 | -0.3594 | -1.0000 | 1.4915 | 0.1898 | 0.9050 | 0.6567 | |
| SUM190PT | HER2amp | Luminal | Ribavirin | 15358.211 | uM | inf | inf | 1.0036 | 1.0036 | 0.0000 | -0.0073 | -0.0327 | 1.3504 | |||
| SUM190PT | HER2amp | Luminal | Torkinib | 15358.211 | uM | 0.12352 | 0.43018 | -0.6414 | -0.6618 | 0.6757 | 0.6069 | 0.9927 | 1.3504 | |||
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 10579.143 | uM | 368.270 | 1000.00000 | -0.3720 | -0.6996 | 0.8761 | 0.2790 | 0.9539 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 12098.143 | uM | 184.02540 | 1000.00000 | -0.3284 | -0.8209 | 0.5739 | 0.3134 | 0.9890 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 12098.158 | uM | 0.01127 | 0.11444 | -0.9807 | -0.9096 | 0.4472 | 0.9166 | 0.9438 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7533.066 | uM | 6.97750 | 6.8250 | 0.0527 | 0.0523 | 5.0000 | 0.1191 | 0.9671 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7534.066 | uM | 7.97910 | 4.70390 | 0.3051 | 0.2458 | 1.2803 | 0.1265 | 0.9847 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 10579.141 | uM | 0.94552 | 29.31350 | -0.0851 | -1.0000 | 0.3199 | 0.4084 | 0.8362 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 12098.158 | uM | 9.92050 | 169.70510 | 0.1308 | -1.0000 | 0.3869 | 0.2087 | 0.9233 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 10579.072 | uM | 38.17410 | 40.38090 | -0.1613 | -0.1622 | 4.9999 | 0.1497 | 0.9502 | 0.9654 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14803.203 | uM | 0.00522 | 0.00940 | -0.4349 | -0.3483 | 0.8989 | 0.9027 | 0.9647 | 1.4290 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14803.203 | uM | 0.00522 | 0.00940 | -0.4349 | -0.3483 | 0.8989 | 0.9027 | 0.9647 | 1.4290 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7534.074 | uM | 0.03580 | 0.07687 | -0.7017 | -0.6263 | 1.0626 | 0.9468 | 0.9861 | 1.1026 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7534.074 | uM | 0.03580 | 0.07687 | -0.7017 | -0.6263 | 1.0626 | 0.9468 | 0.9861 | 1.1026 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7533.074 | uM | 0.06657 | 0.12544 | -0.6770 | -0.6155 | 1.2665 | 0.8771 | 0.9932 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7533.074 | uM | 0.06657 | 0.12544 | -0.6770 | -0.6155 | 1.2665 | 0.8771 | 0.9932 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 15335.203 | uM | 0.01161 | 0.03143 | -0.9577 | -0.9350 | 1.0585 | 1.1505 | 0.9995 | 0.8170 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 15335.203 | uM | 0.01161 | 0.03143 | -0.9577 | -0.9350 | 1.0585 | 1.1505 | 0.9995 | 0.8170 | |
| SUM225CWN | HER2amp | Basal A | Bosutinib | Src | nRTK | 10579.145 | uM | 0.91723 | 7.74360 | -0.0649 | -0.5659 | 0.3548 | 0.4411 | 0.8943 | 1.0664 | |
| SUM225CWN | HER2amp | Basal A | Bosutinib | Src | nRTK | 12098.145 | uM | 1.55050 | 3.34380 | -0.4423 | -0.5615 | 0.9796 | 0.4708 | 0.9506 | 0.9769 | |
| SUM225CWN | HER2amp | Basal A | Celecoxib | COX2 | COX | 10579.136 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6876 | |
| SUM225CWN | HER2amp | Basal A | Chk2 inhibitor II | CHK2 | CHK | 10579.14 | uM | inf | inf | 0.6784 | 0.6784 | 0.0000 | 0.0743 | 0.2850 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 12098.155 | uM | inf | inf | 0.5885 | 0.5885 | 0.0000 | 0.3880 | 0.4982 | 1.0503 |