Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7533.091 | uM | 22.57820 | 54.90490 | -0.1228 | -1.0000 | 1.2363 | 0.1060 | 0.9798 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7534.091 | uM | 6.97750 | 9.72720 | -0.0973 | -0.2218 | 1.1049 | 0.1773 | 0.9890 | 0.9898 | |
| SUM225CWN | HER2amp | Basal A | Etoposide | TOP2 | TOP | 7534.074 | uM | 10.40560 | 10.1190 | 0.0076 | 0.0417 | 3.1158 | 0.2624 | 0.9917 | 1.1026 | |
| SUM225CWN | HER2amp | Basal A | Etoposide | TOP2 | TOP | 7533.074 | uM | 10.92470 | 11.11810 | -0.0499 | -0.0453 | 4.9373 | 0.2631 | 0.9951 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Everolimus | MTOR | MTOR | 12098.164 | uM | 0.03639 | 1.75870 | -0.9574 | -1.0000 | 0.2833 | 0.6799 | 0.8088 | 1.2878 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7534.084 | uM | 0.03012 | 0.08208 | -0.9997 | -1.0000 | 1.0956 | 0.9283 | 0.9950 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7533.084 | uM | 0.09404 | 0.14063 | -0.9915 | -0.9787 | 2.6949 | 0.8471 | 0.9981 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 12098.161 | uM | inf | inf | 0.4834 | 0.4834 | 0.0000 | 0.1703 | 0.2896 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 10579.137 | uM | inf | 7.70680 | 0.5826 | 0.5823 | 4.9879 | 0.0352 | 0.8888 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 10579.142 | uM | 49.87590 | 78.42690 | 0.6694 | -0.4553 | 1.4303 | 0.0300 | 0.7869 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 12098.154 | uM | 31.64750 | 189.2690 | 0.4762 | -1.0000 | 0.6143 | 0.0933 | 0.8454 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 10579.138 | uM | inf | inf | 0.9224 | 0.9224 | 0.0000 | 0.0099 | 0.1840 | 0.9860 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 12098.16 | uM | inf | 21.08720 | 0.8109 | 0.8102 | 4.8078 | -0.0026 | 0.7244 | 0.9575 | ||
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7534.091 | uM | 2.82460 | 3.63060 | -0.9927 | -0.7099 | 3.5202 | 0.4656 | 0.9690 | 0.9898 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7533.091 | uM | 87.78780 | 109.34760 | -0.4535 | -0.9992 | 5.0000 | 0.0613 | 0.9925 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7534.071 | uM | 10.17320 | 12.45780 | -0.8746 | -0.8769 | 5.0000 | 0.3769 | 0.9935 | 1.0807 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7533.098 | uM | 13.0430 | 16.22530 | -0.9473 | -0.9493 | 4.8746 | 0.1539 | 0.9961 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7534.098 | uM | 3.13250 | 4.55140 | -0.9147 | -0.9130 | 2.7807 | 0.3706 | 0.9981 | 0.9286 | |
| SUM225CWN | HER2amp | Basal A | GW843682X | PLK | PLK | 10579.139 | uM | inf | inf | 0.8101 | 0.8101 | 0.0000 | 0.0896 | 0.0081 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | Ibandronate | FDPS | 12098.143 | uM | 412.9920 | 357.42140 | 0.2867 | 0.0436 | 0.6314 | 0.1180 | 0.8938 | 0.9820 | ||
| SUM225CWN | HER2amp | Basal A | Ibandronate | FDPS | 10579.143 | uM | 505.42040 | 634.29890 | 0.3443 | -0.0648 | 0.5364 | 0.1388 | 0.9562 | 0.7678 | ||
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 10579.139 | uM | inf | inf | 0.6972 | 0.6972 | 0.0000 | 0.1100 | -0.0164 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 12098.157 | uM | inf | inf | 0.7855 | 0.7855 | 0.0000 | 0.0460 | 0.3066 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | IKK16 | IKK | NFKB | 10579.1 | uM | 2.91430 | 3.99290 | -0.9851 | -0.9925 | 3.4729 | 0.4626 | 0.9905 | 0.9677 | |
| SUM225CWN | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7533.091 | uM | 15.32370 | 23.72660 | -0.9985 | -1.0000 | 2.5128 | 0.5053 | 0.9962 | 0.7547 |