Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7534.091 | uM | 10.57980 | 18.55160 | -0.9993 | -1.0000 | 1.9562 | 0.5265 | 0.9981 | 0.9898 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7533.067 | uM | 0.11585 | 1.15460 | -0.9946 | -1.0000 | 0.4778 | 0.5454 | 0.8973 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7534.067 | uM | 0.11494 | 0.99902 | -0.9982 | -1.0000 | 0.5081 | 0.5924 | 0.9238 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7534.095 | uM | 0.00261 | 0.12623 | -0.9999 | -1.0000 | 0.2832 | 0.9398 | 0.7408 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7533.095 | uM | 0.03209 | 0.58907 | -0.9854 | -1.0000 | 0.3775 | 0.6854 | 0.8929 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | JNK-IN-5A | JNK | JNK | 12098.144 | uM | inf | inf | 0.8183 | 0.8183 | 0.0000 | 0.1139 | 0.5003 | 1.1959 | |
| SUM225CWN | HER2amp | Basal A | JNK-IN-5A | JNK | JNK | 10579.144 | uM | 2.03580 | 1.68810 | 0.3098 | 0.3040 | 5.0000 | 0.2207 | 0.9721 | 0.9576 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 12098.161 | uM | 7.89360 | 24.63020 | -0.3465 | -1.0000 | 0.9655 | 0.1605 | 0.9832 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 10579.137 | uM | 6.83690 | 7.39060 | -0.2373 | -0.2380 | 4.9998 | 0.1278 | 0.9841 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7533.098 | uM | 0.68808 | 0.72289 | -0.1508 | -0.1399 | 4.9987 | 0.2359 | 0.9929 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7534.098 | uM | 0.62293 | 0.82639 | -0.3240 | -0.3217 | 1.7576 | 0.2906 | 0.9956 | 0.9286 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 12098.154 | uM | 0.11096 | 0.24122 | -0.9287 | -0.9769 | 1.3948 | 0.7432 | 0.9935 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12098.154 | uM | 1.18010 | 2.08150 | -0.7514 | -0.8076 | 1.6941 | 0.4116 | 0.9814 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10579.142 | uM | 0.85957 | 2.07090 | -0.9176 | -0.9154 | 1.1835 | 0.5543 | 0.9976 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7534.084 | uM | inf | inf | 0.9557 | 0.9557 | 0.0000 | 0.0114 | 0.0130 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7533.084 | uM | inf | inf | 0.9294 | 0.9294 | 0.0000 | -0.0224 | 0.2330 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 10579.145 | uM | 0.10501 | 0.22014 | -0.5744 | -0.5606 | 1.0159 | 0.6768 | 0.9729 | 1.0664 | |
| SUM225CWN | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 10579.145 | uM | 0.10501 | 0.22014 | -0.5744 | -0.5606 | 1.0159 | 0.6768 | 0.9729 | 1.0664 | |
| SUM225CWN | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 12098.145 | uM | 0.06807 | 0.12086 | -0.6944 | -0.6272 | 1.4159 | 0.7837 | 0.9869 | 0.9769 | |
| SUM225CWN | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 12098.145 | uM | 0.06807 | 0.12086 | -0.6944 | -0.6272 | 1.4159 | 0.7837 | 0.9869 | 0.9769 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 10579.135 | uM | 4.48940 | 10.87060 | -0.4907 | -0.7214 | 1.0099 | 0.3005 | 0.930 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 12098.135 | uM | 4.4780 | 9.06550 | -0.2888 | -0.4856 | 0.9622 | 0.2497 | 0.9858 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Nilotinib | ABL | nRTK | 10579.145 | uM | inf | inf | 0.7382 | 0.7382 | 0.0000 | 0.1219 | 0.2766 | 1.0664 | |
| SUM225CWN | HER2amp | Basal A | Nilotinib | ABL | nRTK | 12098.145 | uM | inf | inf | 0.9374 | 0.9374 | 0.0000 | 0.0259 | 0.3617 | 0.9769 | |
| SUM225CWN | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 12098.159 | uM | 2.24320 | 4.11360 | -0.9847 | -1.0000 | 1.8117 | 0.5831 | 0.9949 | 1.0261 |