Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 10579.14 | uM | 2.24220 | 3.78720 | -0.9927 | -0.9999 | 2.0957 | 0.5832 | 0.9989 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | NU6102 | CDK1/2 | CDK | 12098.147 | uM | 43.87710 | 54.63610 | -0.4591 | -0.9968 | 4.9999 | 0.2268 | 0.8542 | 1.1904 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7533.066 | uM | 15.83360 | 22.27750 | -0.9482 | -1.0000 | 3.2175 | 0.1961 | 0.9891 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7534.066 | uM | 20.6350 | 33.12770 | -0.6725 | -1.0000 | 2.3208 | 0.1603 | 0.9915 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 12098.147 | uM | 5.27270 | 5.62770 | -0.1980 | -0.1926 | 5.0000 | 0.3237 | 0.9619 | 1.1904 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 10579.087 | uM | 0.00169 | 0.00768 | -0.8823 | -0.6699 | 0.5607 | 1.0541 | 0.9637 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Oxamflatin | HDAC | HDAC | 12098.147 | uM | 0.85121 | 2.73110 | -0.9191 | -1.0000 | 0.9424 | 0.5630 | 0.9647 | 1.1904 | |
| SUM225CWN | HER2amp | Basal A | PD 98059 | MEK | MAPK | 12098.159 | uM | 10.17520 | 7.80930 | 0.3290 | 0.3669 | 5.0000 | 0.1714 | 0.8727 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | PD 98059 | MEK | MAPK | 10579.136 | uM | 24.91990 | 24.74360 | 0.0183 | 0.0174 | 4.9999 | 0.0770 | 0.9827 | 0.6876 | |
| SUM225CWN | HER2amp | Basal A | PD173074 | FGFR1/3 | RTK | 10579.1 | uM | 13.56940 | 23.08410 | -0.8067 | -1.0000 | 2.0677 | 0.2038 | 0.9791 | 0.9677 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 12098.155 | uM | inf | inf | 0.7400 | 0.7400 | 0.0000 | 0.1295 | 0.3373 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 12098.155 | uM | inf | inf | 0.7400 | 0.7400 | 0.0000 | 0.1295 | 0.3373 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7533.095 | uM | inf | inf | 0.7658 | 0.7658 | 0.0000 | 0.0600 | 0.0756 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7534.095 | uM | inf | inf | 0.8515 | 0.8515 | 0.0000 | 0.0060 | 0.2793 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7534.065 | uM | inf | inf | 0.8726 | 0.8726 | 0.0000 | -0.0301 | 0.3917 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7533.065 | uM | inf | inf | 0.6455 | 0.6455 | 0.0000 | 0.0965 | 0.4664 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 7533.067 | uM | 87.46430 | 215.85730 | 0.3519 | -0.3881 | 0.6360 | 0.0789 | 0.8937 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 7534.067 | uM | 21.72610 | 22.1420 | 0.0420 | -0.0133 | 1.3846 | 0.1628 | 0.9824 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ribavirin | 15403.211 | uM | inf | inf | 0.4799 | 0.4799 | 0.0000 | 0.2473 | 0.3950 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Ro 32-0432 | PKC | PKC | 10579.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0168 | -0.2942 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 10579.144 | uM | inf | inf | 0.8597 | 0.8597 | 0.0000 | -0.0118 | 0.3052 | 0.9576 | |
| SUM225CWN | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 12098.144 | uM | inf | 19.97250 | 0.7121 | 0.7120 | 5.0000 | 0.0215 | 0.8105 | 1.1959 | |
| SUM225CWN | HER2amp | Basal A | Selumetinib | MEK | MAPK | 12098.155 | uM | inf | 0.00788 | 0.8639 | 0.8687 | 4.9796 | 0.0832 | 0.6381 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 10579.141 | uM | 0.44576 | 2.38110 | -0.9858 | -1.0000 | 0.6557 | 0.6692 | 0.8501 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 12098.158 | uM | 0.94124 | 3.5940 | -0.9729 | -1.0000 | 0.8200 | 0.5030 | 0.9740 | 1.1438 |