Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 12969.174 | uM | 12.06230 | 475.56020 | 0.1360 | -1.0000 | 0.2990 | 0.2230 | 0.7865 | 1.1194 | |
| SUM52PE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13570.174 | uM | inf | 0.04829 | 0.7255 | 0.6325 | 4.7807 | 0.2216 | 0.7871 | 0.5197 | |
| SUM52PE | HR+ | Luminal | Docetaxel | TUBB | TUBB | 12969.002 | uM | 0.00197 | 0.00104 | 0.1240 | 0.1207 | 0.4307 | 0.5928 | 0.7473 | 1.0653 | |
| SUM52PE | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9878.002 | uM | 0.00219 | 0.00315 | -0.3020 | -0.2924 | 1.2701 | 0.8102 | 0.9880 | 1.3437 | |
| SUM52PE | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9889.002 | uM | 0.00130 | 0.00174 | -0.3619 | -0.3400 | 1.7739 | 0.9146 | 0.9936 | 1.1879 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9889.034 | uM | 0.08331 | 0.14745 | -0.8893 | -0.5445 | 1.2903 | 0.7318 | 0.9567 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7540.078 | uM | 0.12817 | 0.16578 | -0.9997 | -0.8307 | 3.8038 | 0.8677 | 0.9932 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7923.017 | uM | 0.00162 | 0.03188 | -0.9999 | -1.0000 | 0.3688 | 1.3173 | 0.790 | 0.6267 | |
| SUM52PE | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9878.017 | uM | 0.30083 | 0.45917 | -0.9967 | -0.6770 | 2.0246 | 0.7526 | 0.9685 | 1.3463 | |
| SUM52PE | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7540.09 | uM | inf | inf | -0.0311 | -0.0311 | 0.0000 | 0.3195 | 0.4818 | 0.5702 | |
| SUM52PE | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7541.091 | uM | 55.96950 | 95.19380 | 0.3900 | -0.7153 | 1.6722 | 0.0421 | 0.9360 | 1.4119 | |
| SUM52PE | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7539.092 | uM | 12.30920 | 11.93560 | 0.0733 | 0.0628 | 4.3571 | 0.0841 | 0.9766 | 1.2233 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 7541.074 | uM | 2.57960 | 4.42740 | -0.5256 | -0.4690 | 1.2247 | 0.4922 | 0.9923 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Everolimus | MTOR | MTOR | 11852.156 | uM | 0.01372 | 0.85090 | -0.9736 | -1.0000 | 0.2662 | 0.7618 | 0.7760 | 1.0109 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7541.084 | uM | 0.21080 | 0.39949 | -0.9703 | -0.9992 | 1.7177 | 0.7205 | 0.9913 | 1.2092 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10695.149 | uM | 86.4740 | 40.52320 | 0.6748 | 0.2751 | 1.0539 | 0.0440 | 0.8238 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 11852.161 | uM | 40.46870 | 29.18790 | 0.2988 | 0.2250 | 1.8292 | 0.0858 | 0.9627 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11852.154 | uM | 8.83230 | 7.87840 | 0.2108 | 0.2100 | 4.7656 | 0.0991 | 0.9282 | 1.2816 | |
| SUM52PE | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10695.154 | uM | 19.78620 | 45.25810 | 0.2100 | -0.9668 | 1.3007 | 0.0780 | 0.9755 | 1.4756 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7923.016 | uM | inf | inf | -0.8122 | -0.8122 | 0.0000 | 1.1063 | -0.0557 | 0.6280 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7540.016 | uM | 8.32790 | 8.00520 | 0.0903 | 0.0896 | 4.9971 | 0.1567 | 0.8380 | 0.9455 | |
| SUM52PE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9878.019 | uM | 8.80480 | 9.32790 | -0.1460 | -0.1495 | 4.5342 | 0.1215 | 0.9879 | 1.4790 | |
| SUM52PE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9889.012 | uM | 0.01345 | 0.01458 | -0.3687 | -0.1222 | 2.7132 | 0.7451 | 0.9620 | 1.3671 | |
| SUM52PE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9878.012 | uM | 0.00869 | 0.01198 | -0.3961 | -0.3029 | 1.4774 | 0.9011 | 0.9907 | 1.2431 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9878.011 | uM | 0.00732 | 0.00992 | -0.4142 | -0.1960 | 1.0863 | 0.8674 | 0.9254 | 1.2938 |