Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 11852.16 | uM | 14.77880 | 13.0570 | 0.1470 | 0.1318 | 2.4703 | 0.1317 | 0.9476 | 1.2383 | ||
| SUM52PE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10695.15 | uM | 4.74640 | 5.78340 | -0.0819 | -0.1663 | 1.4529 | 0.1768 | 0.9932 | 1.3520 | ||
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 9878.001 | uM | 0.11784 | 0.35409 | -0.5428 | -0.5522 | 0.6762 | 0.5438 | 0.9799 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK1070916 | AURK | AURK | 9889.001 | uM | 0.20965 | 0.55738 | -0.5741 | -0.5720 | 0.7799 | 0.4868 | 0.9906 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7539.092 | uM | inf | inf | 0.2651 | 0.2651 | 0.0000 | 0.2678 | 0.5391 | 1.2233 | |
| SUM52PE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7540.09 | uM | inf | inf | -0.7641 | -0.7641 | 0.0000 | 0.7833 | 0.5535 | 0.5702 | |
| SUM52PE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7541.098 | uM | 1.83130 | 4.36550 | -0.7103 | -0.8398 | 1.1347 | 0.4759 | 0.9625 | 1.6271 | |
| SUM52PE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7539.098 | uM | 2.49030 | 3.97350 | -0.7635 | -0.8176 | 2.0736 | 0.4865 | 0.9675 | 1.6240 | |
| SUM52PE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7541.091 | uM | 2.32450 | 9.19540 | -0.8795 | -1.0000 | 0.7989 | 0.4210 | 0.9868 | 1.4119 | |
| SUM52PE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7541.071 | uM | 5.22250 | 8.00390 | -0.8014 | -0.8235 | 2.2799 | 0.4126 | 0.9881 | 1.3491 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9889.001 | uM | 0.00596 | 0.00650 | -0.6000 | -0.1837 | 3.5848 | 0.7728 | 0.9070 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9878.001 | uM | 0.00532 | 0.00606 | -0.2712 | -0.1337 | 1.8195 | 0.7604 | 0.9501 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9878.001 | uM | 0.02217 | 0.02482 | -0.4420 | -0.2648 | 3.7582 | 0.7026 | 0.9845 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9889.001 | uM | 0.02221 | 0.02342 | -0.2156 | -0.1520 | 5.0000 | 0.6376 | 0.9886 | 1.4638 | |
| SUM52PE | HR+ | Luminal | Ibandronate | FDPS | 11852.143 | uM | 24.46870 | 27.570 | -0.1219 | -0.0911 | 1.4031 | 0.3170 | 0.9903 | 1.2284 | ||
| SUM52PE | HR+ | Luminal | Ibandronate | FDPS | 10695.143 | uM | 44.74560 | 60.12140 | -0.2519 | -0.2540 | 1.3909 | 0.3183 | 0.9906 | 1.2894 | ||
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10695.151 | uM | 1.65180 | 0.75962 | 0.2610 | 0.4363 | 2.6534 | 0.1764 | 0.8966 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 11852.157 | uM | 5.23170 | 7.83140 | 0.1296 | -0.1209 | 0.5369 | 0.1970 | 0.9101 | 1.4174 | |
| SUM52PE | HR+ | Luminal | IKK16 | IKK | NFKB | 7539.093 | uM | 1.34480 | 3.16990 | -0.9190 | -1.0000 | 1.2813 | 0.5640 | 0.9664 | 1.5919 | |
| SUM52PE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7540.09 | uM | 1.32850 | 1.48930 | -0.8299 | -0.1742 | 2.6167 | 0.6147 | 0.6850 | 0.5702 | |
| SUM52PE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7539.092 | uM | 21.02320 | 55.97160 | -0.9661 | -1.0000 | 1.1219 | 0.3851 | 0.9904 | 1.2233 | |
| SUM52PE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7541.091 | uM | 25.05540 | 56.75860 | -0.9595 | -1.0000 | 1.3435 | 0.3630 | 0.9982 | 1.4119 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7541.067 | uM | 0.01768 | 0.05412 | -0.9804 | -0.7175 | 0.7956 | 0.8388 | 0.9347 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7541.095 | uM | 0.00031 | 0.00056 | -0.9787 | -0.3061 | 0.7899 | 1.0595 | 0.6623 | 1.4542 | |
| SUM52PE | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7539.095 | uM | 0.00619 | 0.15845 | -0.9933 | -1.0000 | 0.3387 | 0.8621 | 0.8539 | 1.1392 |