Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7546.074 | uM | 1.40170 | 3.59650 | -0.9706 | -1.0000 | 1.1659 | 0.5733 | 0.9954 | 0.8465 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7546.074 | uM | 1.40170 | 3.59650 | -0.9706 | -1.0000 | 1.1659 | 0.5733 | 0.9954 | 0.8465 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 14849.203 | uM | 0.01686 | 0.02097 | -0.9900 | -0.9877 | 5.0000 | 1.2349 | 0.9993 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 14849.203 | uM | 0.01686 | 0.02097 | -0.9900 | -0.9877 | 5.0000 | 1.2349 | 0.9993 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 12608.17 | uM | inf | 4.16560 | 0.6154 | 0.6143 | 5.0000 | 0.1122 | 0.7923 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 13070.177 | uM | 0.06571 | 0.08431 | -0.9999 | -0.9924 | 4.3883 | 0.9456 | 0.9920 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Chloroquine | 13070.177 | uM | 7.53590 | 14.91010 | -0.9998 | -1.0000 | 1.6100 | 0.4579 | 0.7490 | 0.9040 | |||
| T47DKBLUC | Unknown | Unknown | Dactolisib | PI3K | PI3K | 12608.155 | uM | 0.45477 | 0.27074 | 0.4920 | 0.4626 | 5.0000 | 0.2439 | 0.8734 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Dichloroacetate | PDK | PDK | 13070.176 | uM | inf | inf | 0.7638 | 0.7638 | 0.0000 | 0.0901 | 0.5163 | 0.9664 | |
| T47DKBLUC | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 13070.174 | uM | 0.07509 | 0.04598 | 0.5170 | 0.4319 | 4.0634 | 0.3402 | 0.8236 | 0.7993 | |
| T47DKBLUC | Unknown | Unknown | Docetaxel | TUBB | TUBB | 13070.002 | uM | 0.01168 | 0.01504 | -0.3570 | -0.3140 | 1.9304 | 0.6646 | 0.9968 | 0.7888 | |
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7544.092 | uM | inf | inf | 0.9208 | 0.9208 | 0.0000 | 0.0137 | -0.0102 | 1.1147 | |
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7545.092 | uM | inf | inf | 0.9211 | 0.9211 | 0.0000 | -0.0109 | 0.4842 | 0.9794 | |
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7546.091 | uM | inf | 25.29620 | 0.6366 | 0.4707 | 0.8202 | 0.0468 | 0.9418 | 0.9137 | |
| T47DKBLUC | Unknown | Unknown | Etoposide | TOP2 | TOP | 7546.074 | uM | 1.42620 | 1.74870 | -0.2071 | -0.1331 | 1.1580 | 0.4349 | 0.9856 | 0.8465 | |
| T47DKBLUC | Unknown | Unknown | Everolimus | MTOR | MTOR | 12608.164 | uM | 3.22850 | 44.48590 | -0.3473 | -1.0000 | 0.4188 | 0.3159 | 0.8078 | 1.1044 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 7546.084 | uM | 0.04180 | 0.06384 | -0.9926 | -0.9946 | 2.5849 | 0.9923 | 0.9974 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 12608.166 | uM | 131.28130 | 123.39570 | 0.7748 | 0.1328 | 4.9834 | 0.0232 | 0.6626 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 12608.167 | uM | inf | inf | 0.9819 | 0.9819 | 0.0000 | -0.0030 | 0.1862 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 12608.169 | uM | inf | inf | 0.8859 | 0.8859 | 0.0000 | 0.0116 | 0.3497 | 1.2559 | ||
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7544.092 | uM | inf | inf | 0.8657 | 0.8657 | 0.0000 | 0.0626 | 0.0671 | 1.1147 | |
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7545.098 | uM | inf | 0.28442 | 0.4163 | 0.6197 | 0.6883 | 0.1888 | 0.5808 | 1.1555 | |
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7545.092 | uM | inf | 0.24280 | 0.9122 | 0.9282 | 4.6306 | 0.0113 | 0.6526 | 0.9794 | |
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7546.091 | uM | inf | 0.42964 | 0.7488 | 0.7283 | 5.0000 | 0.1086 | 0.9374 | 0.9137 | |
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7544.098 | uM | 13.71230 | 21.16040 | -0.9149 | -1.0000 | 2.5323 | 0.2565 | 0.9739 | 1.2438 |