Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7546.098 | uM | inf | 0.60070 | 0.5617 | 0.5605 | 1.5819 | 0.1594 | 0.9761 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7546.071 | uM | 5.6070 | 7.54970 | -0.9685 | -0.9806 | 3.6491 | 0.4587 | 0.9780 | 0.9919 | |
| T47DKBLUC | Unknown | Unknown | Ibandronate | FDPS | 12608.143 | uM | 102.5170 | 104.09350 | -0.0226 | -0.0205 | 2.6379 | 0.1919 | 0.9927 | 1.1322 | ||
| T47DKBLUC | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 12608.171 | uM | 59.36460 | 784.13470 | 0.5749 | -1.0000 | 0.4257 | 0.1093 | 0.8147 | 1.0643 | |
| T47DKBLUC | Unknown | Unknown | IKK16 | IKK | NFKB | 7544.093 | uM | 4.14560 | 5.44390 | -0.9518 | -0.9524 | 3.9138 | 0.4403 | 0.9870 | 1.2382 | |
| T47DKBLUC | Unknown | Unknown | IKK16 | IKK | NFKB | 7545.1 | uM | 3.14960 | 3.99390 | -0.9669 | -0.9682 | 4.5357 | 0.4461 | 0.9927 | 1.1396 | |
| T47DKBLUC | Unknown | Unknown | Imatinib | ABL/KIT/PDGFR | nRTK | 7544.092 | uM | 22.78430 | 32.06150 | -0.9669 | -0.9803 | 3.1776 | 0.4751 | 0.9878 | 1.1147 | |
| T47DKBLUC | Unknown | Unknown | Imatinib | ABL/KIT/PDGFR | nRTK | 7545.092 | uM | 21.72750 | 30.76630 | -0.9856 | -0.9957 | 3.1501 | 0.4575 | 0.9950 | 0.9794 | |
| T47DKBLUC | Unknown | Unknown | Imatinib | ABL/KIT/PDGFR | nRTK | 7546.091 | uM | 15.51280 | 25.90320 | -0.9892 | -1.0000 | 2.1428 | 0.4938 | 0.9955 | 0.9137 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 7546.067 | uM | 0.12180 | 1.24590 | -0.9950 | -1.0000 | 0.4725 | 0.5386 | 0.8837 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ixabepilone | TUBB | TUBB | 7546.095 | uM | 0.01571 | 1.40280 | -0.9954 | -1.0000 | 0.2446 | 0.6612 | 0.6033 | 0.8399 | |
| T47DKBLUC | Unknown | Unknown | Ixabepilone | TUBB | TUBB | 7544.095 | uM | 0.02431 | 1.10150 | -0.9737 | -1.0000 | 0.2881 | 0.6556 | 0.6937 | 1.0175 | |
| T47DKBLUC | Unknown | Unknown | Ixabepilone | TUBB | TUBB | 7545.095 | uM | 0.00970 | 0.02021 | -0.9795 | -0.3082 | 0.6544 | 0.7119 | 0.7269 | 1.0123 | |
| T47DKBLUC | Unknown | Unknown | JNK-IN-5A | JNK | JNK | 12608.168 | uM | inf | inf | 0.9658 | 0.9658 | 0.0000 | 0.0146 | 0.0000 | 1.0486 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 12608.166 | uM | 28.92460 | 48.3580 | 0.3895 | -0.8971 | 1.9994 | 0.0582 | 0.9461 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 7544.098 | uM | inf | inf | 0.9586 | 0.9586 | 0.0000 | 0.0541 | -0.0405 | 1.2438 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 7545.098 | uM | inf | inf | 0.7009 | 0.7009 | 0.0000 | 0.1154 | 0.4976 | 1.1555 | |
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 7546.098 | uM | 12.52260 | 29.62470 | 0.3428 | -1.0000 | 1.2759 | 0.0619 | 0.8726 | 0.8495 | |
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 12608.167 | uM | 0.14055 | 0.24910 | -0.9323 | -0.9558 | 1.8674 | 0.7486 | 0.9989 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12608.167 | uM | 7.00030 | 8.19070 | -0.5949 | -0.5964 | 4.9993 | 0.1398 | 0.9962 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | Mebendazole | 13070.174 | uM | 6.44240 | 149.04650 | -0.0794 | -1.0000 | 0.3497 | 0.2663 | 0.7011 | 0.7993 | |||
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 7546.084 | uM | 0.23111 | 0.19502 | 0.0496 | 0.1191 | 1.6023 | 0.5209 | 0.9670 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methylglyoxal | 13070.184 | uM | 508.29240 | 1000.00000 | -0.9924 | -0.8019 | 1.4142 | 0.5414 | 0.9222 | 0.8653 | |||
| T47DKBLUC | Unknown | Unknown | MG-132 | Proteasome | Proteasome | 14182.189 | uM | 0.19293 | 0.21827 | -1.0000 | -0.4268 | 5.0000 | 0.7445 | 0.650 | 0.3468 | |
| T47DKBLUC | Unknown | Unknown | MG-132 | Proteasome | Proteasome | 14182.189 | uM | 0.19293 | 0.21827 | -1.0000 | -0.4268 | 5.0000 | 0.7445 | 0.650 | 0.3468 |