Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
T47DKBLUC
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14628.189
uM
0.17560
0.28579
 -0.9767 -0.9852 2.2353 0.9189
0.9813
 0.7555
T47DKBLUC
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14628.189
uM
0.17560
0.28579
 -0.9767 -0.9852 2.2353 0.9189
0.9813
 0.7555
T47DKBLUC
Unknown
Unknown
 MG-132
Proteasome
Proteasome
12608.17
uM
0.13489
0.16763
 -0.9557 -0.9486 4.8948 0.9084
0.9968
 1.0776
T47DKBLUC
Unknown
Unknown
 MG-132
Proteasome
Proteasome
12608.17
uM
0.13489
0.16763
 -0.9557 -0.9486 4.8948 0.9084
0.9968
 1.0776
T47DKBLUC
Unknown
Unknown
 Pevonedistat
NAE1
NAE1
12608.135
uM
0.15085
0.13952
 0.2081 0.1616 5.0000 0.4217
0.9692
 1.2417
T47DKBLUC
Unknown
Unknown
 Nelfinavir
13070.174
uM
inf
inf
 1.0500 1.0500 0.0000 0.0140
0.0000
 0.7993
T47DKBLUC
Unknown
Unknown
 Nilotinib
ABL
nRTK
12608.17
uM
inf
inf
 0.9687 0.9687 0.0000 0.0606
0.0000
 1.0776
T47DKBLUC
Unknown
Unknown
 NSC 663284
CDC25
CDC
12608.152
uM
3.5040
5.39940
 -0.9460 -0.9563 2.4725 0.5549
0.9978
 1.1477
T47DKBLUC
Unknown
Unknown
 NU6102
CDK1/2
CDK
12608.147
uM
39.84450
90.57230
 0.2005 -1.0000 1.3378 0.1063
0.9593
 1.3009
T47DKBLUC
Unknown
Unknown
 Nutlin 3a
MDM2
MDM2
7544.066
uM
54.87290
107.74220
 0.3707 -1.0000 1.6282 0.0929
0.8708
 1.0898
T47DKBLUC
Unknown
Unknown
 Nutlin 3a
MDM2
MDM2
7545.066
uM
26.99770
65.54360
 -0.0153 -1.0000 1.2386 0.1570
0.9171
 1.2546
T47DKBLUC
Unknown
Unknown
 Nutlin 3a
MDM2
MDM2
7546.066
uM
35.39930
100.5350
 0.2077 -1.0000 1.0525 0.0787
0.9476
 0.8758
T47DKBLUC
Unknown
Unknown
 Olomoucine II
CDK1
CDK
12608.147
uM
8.56650
7.48840
 0.2356 0.2405 4.8755 0.2156
0.9274
 1.3009
T47DKBLUC
Unknown
Unknown
 Omipalisib
PI3K
PI3K
7544.087
uM
0.02145
0.03016
 -0.2919 -0.1951 0.9662 0.6448
0.9818
 1.1715
T47DKBLUC
Unknown
Unknown
 Omipalisib
PI3K
PI3K
7545.087
uM
0.01629
0.03193
 -0.5472 -0.4318 0.9249 0.7648
0.9922
 1.1323
T47DKBLUC
Unknown
Unknown
 Oxamflatin
HDAC
HDAC
12608.147
uM
1.41050
3.00680
 -0.9054 -0.9979 1.4496 0.5366
0.9863
 1.3009
T47DKBLUC
Unknown
Unknown
 PD 98059
MEK
MAPK
12608.152
uM
inf
inf
 0.9193 0.9193 0.0000 0.0522
0.0000
 1.1477
T47DKBLUC
Unknown
Unknown
 PD173074
FGFR1/3
RTK
7545.1
uM
17.05940
30.44070
 -0.6468 -1.0000 1.8972 0.2343
0.9490
 1.1396
T47DKBLUC
Unknown
Unknown
 PD173074
FGFR1/3
RTK
7544.093
uM
8.09160
11.64830
 -0.9258 -1.0000 3.0154 0.2267
0.9758
 1.2382
T47DKBLUC
Unknown
Unknown
 PD184352
MEK
MAPK
12608.155
uM
inf
inf
 0.9291 0.9291 0.0000 0.0321
0.0410
 1.1556
T47DKBLUC
Unknown
Unknown
 PD184352
MEK
MAPK
12608.155
uM
inf
inf
 0.9291 0.9291 0.0000 0.0321
0.0410
 1.1556
T47DKBLUC
Unknown
Unknown
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7544.095
uM
inf
0.07571
 0.7085 0.6381 0.1573 0.2323
0.6143
 1.0175
T47DKBLUC
Unknown
Unknown
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7545.095
uM
inf
0.05456
 0.7150 0.6999 0.4189 0.2366
0.7634
 1.0123
T47DKBLUC
Unknown
Unknown
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7546.095
uM
0.24555
0.14696
 0.2826 0.3262 2.0588 0.5126
0.9837
 0.8399
T47DKBLUC
Unknown
Unknown
 PS-1145
IKK
NFKB
7545.065
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0500
-45672.5960
 0.9803