Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10580.141 | uM | 2.6130 | 4.64090 | -0.2527 | -0.3770 | 0.9782 | 0.3831 | 0.8958 | 0.7451 | |
| UACC-812 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10754.153 | uM | 4.07350 | 16.32650 | -0.2724 | -0.7599 | 0.6657 | 0.2742 | 0.9846 | 1.2774 | |
| UACC-812 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7926.068 | uM | 0.04604 | 0.01478 | 0.1819 | 0.3009 | 0.8104 | 0.4991 | 0.8688 | 0.9443 | |
| UACC-812 | HER2amp | Luminal | Sulindac sulfide | COX1/2 | COX | 10580.136 | uM | inf | inf | 0.9119 | 0.9119 | 0.0000 | 0.1503 | 0.0000 | 0.7205 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9913.002 | uM | 0.00910 | 0.00918 | -0.0642 | -0.0148 | 3.5121 | 0.6730 | 0.9610 | 0.6723 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10267.002 | uM | 0.00511 | 0.00565 | -0.4735 | -0.3262 | 5.0000 | 0.8803 | 0.9892 | 0.4069 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10150.002 | uM | 0.00749 | 0.00833 | -0.4274 | -0.3478 | 5.0000 | 0.8685 | 0.9919 | 0.4064 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 13078.002 | uM | 0.00883 | 0.00969 | -0.3363 | -0.2963 | 4.9971 | 0.8286 | 0.9937 | 0.6437 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 10580.14 | uM | 0.93394 | 1.67770 | -0.5328 | -0.5965 | 1.3405 | 0.4390 | 0.9681 | 0.8679 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 10754.152 | uM | 0.83503 | 1.28810 | -0.4491 | -0.4246 | 1.4183 | 0.3861 | 0.9870 | 1.0670 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 11938.159 | uM | 1.02030 | 1.27090 | -0.9998 | -0.9990 | 5.0000 | 0.5078 | 0.9969 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11938.135 | uM | inf | inf | 0.7739 | 0.7739 | 0.0000 | 0.2024 | 0.0000 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10580.135 | uM | inf | inf | 0.8208 | 0.8208 | 0.0000 | 0.1245 | 0.3065 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10754.148 | uM | inf | inf | 0.7499 | 0.7499 | 0.0000 | 0.1004 | 0.5026 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 10580.144 | uM | 0.01503 | 3.40750 | -0.9570 | -1.0000 | 0.2026 | 0.7434 | 0.6450 | 0.8541 | |
| UACC-812 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 11938.144 | uM | 0.04943 | 8.74340 | -0.3947 | -1.0000 | 0.2123 | 0.6650 | 0.8683 | 0.6445 | |
| UACC-812 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 10754.144 | uM | 0.34168 | 3.58480 | -0.9978 | -1.0000 | 0.4674 | 0.6385 | 0.9453 | 0.8390 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 10267.121 | uM | 0.02610 | 0.03070 | -0.9975 | -0.6117 | 4.9211 | 0.9985 | 0.9109 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7926.077 | uM | 0.07996 | 0.84673 | -0.8946 | -1.0000 | 0.4655 | 0.7713 | 0.9168 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Torkinib | 15404.211 | uM | 0.00005 | 0.00056 | -0.8141 | -0.8007 | 0.3960 | 1.4387 | 0.9967 | 0.5754 | |||
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11938.16 | uM | inf | inf | 0.4474 | 0.4474 | 0.0000 | 0.2139 | 0.1216 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10754.15 | uM | 4.88740 | 31.99640 | -0.0676 | -1.0000 | 0.5847 | 0.2438 | 0.8712 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10580.138 | uM | 16.92470 | 30.4930 | -0.8643 | -1.0000 | 1.8661 | 0.3447 | 0.8943 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 7547.093 | uM | inf | inf | 0.8184 | 0.8184 | 0.0000 | 0.1585 | -0.1108 | 1.1087 | |
| UACC-812 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 10420.093 | uM | inf | inf | 1.0207 | 1.0207 | 0.0000 | 0.0248 | 0.0000 | 0.5629 |