Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 11852.144 | uM | 0.99993 | 0.73942 | -0.0903 | 0.3895 | 5.0000 | 0.2056 | 0.5793 | 1.2876 | |
| SUM52PE | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10695.144 | uM | 0.40618 | 0.44426 | -0.2818 | -0.2826 | 4.9999 | 0.5520 | 0.9957 | 1.2333 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 10695.149 | uM | 7.51690 | 13.91570 | -0.6803 | -1.0000 | 1.7839 | 0.2114 | 0.9575 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 11852.161 | uM | 8.98070 | 16.22710 | -0.8083 | -1.0000 | 1.8570 | 0.2637 | 0.9662 | 1.5680 | |
| SUM52PE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7541.098 | uM | inf | inf | 0.7993 | 0.7993 | 0.0000 | 0.1329 | 0.0794 | 1.6271 | |
| SUM52PE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7539.098 | uM | inf | inf | 0.8510 | 0.8510 | 0.0000 | 0.1252 | 0.3898 | 1.6240 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 11852.154 | uM | 0.08003 | 0.1480 | -0.9211 | -0.9089 | 1.6849 | 0.7867 | 0.9986 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 10695.154 | uM | 0.26148 | 0.34978 | -0.8474 | -0.8430 | 3.3962 | 0.6504 | 0.9991 | 1.4756 | |
| SUM52PE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10695.154 | uM | 0.15968 | 1.18410 | -0.9300 | -1.0000 | 0.5483 | 0.5430 | 0.9516 | 1.4756 | |
| SUM52PE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11852.154 | uM | 0.16629 | 0.99316 | -0.9393 | -1.0000 | 0.6147 | 0.5442 | 0.9694 | 1.2816 | |
| SUM52PE | HR+ | Luminal | Mebendazole | 12969.174 | uM | 0.22867 | 0.14055 | 0.0884 | 0.2134 | 1.1431 | 0.3812 | 0.9296 | 1.1194 | |||
| SUM52PE | HR+ | Luminal | Mebendazole | 13570.174 | uM | 0.08562 | 0.10383 | -0.8517 | -0.8117 | 5.0000 | 0.9710 | 0.9580 | 0.5197 | |||
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7541.084 | uM | inf | inf | 0.9224 | 0.9224 | 0.0000 | 0.0098 | 0.2324 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methylglyoxal | 13651.184 | uM | inf | inf | -0.6727 | -0.6727 | 0.0000 | 0.8697 | 0.5569 | 0.7406 | |||
| SUM52PE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14290.189 | uM | 0.10536 | 0.12055 | -0.7967 | -0.4805 | 5.0000 | 0.7678 | 0.8845 | 0.5261 | |
| SUM52PE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14290.189 | uM | 0.10536 | 0.12055 | -0.7967 | -0.4805 | 5.0000 | 0.7678 | 0.8845 | 0.5261 | |
| SUM52PE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 11852.145 | uM | 0.07167 | 0.08515 | -0.7150 | -0.6832 | 5.0000 | 0.8905 | 0.9965 | 1.5550 | |
| SUM52PE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 11852.145 | uM | 0.07167 | 0.08515 | -0.7150 | -0.6832 | 5.0000 | 0.8905 | 0.9965 | 1.5550 | |
| SUM52PE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10695.145 | uM | 0.07446 | 0.09028 | -0.8612 | -0.8103 | 5.0000 | 0.9308 | 0.9967 | 1.1360 | |
| SUM52PE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10695.145 | uM | 0.07446 | 0.09028 | -0.8612 | -0.8103 | 5.0000 | 0.9308 | 0.9967 | 1.1360 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 10695.148 | uM | 0.22871 | 0.60119 | 0.0411 | -0.2086 | 0.3608 | 0.4862 | 0.9139 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 11852.135 | uM | 0.51894 | 0.64597 | -0.4142 | -0.2919 | 2.1000 | 0.4515 | 0.9890 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Nelfinavir | 13570.174 | uM | inf | inf | 0.3681 | 0.3681 | 0.0000 | 0.1153 | 0.4883 | 0.5197 | |||
| SUM52PE | HR+ | Luminal | Nelfinavir | 12969.174 | uM | 8.40510 | 18.55740 | -0.4010 | -1.0000 | 1.3871 | 0.2195 | 0.9278 | 1.1194 | |||
| SUM52PE | HR+ | Luminal | Nilotinib | ABL | nRTK | 11852.145 | uM | inf | inf | 1.0081 | 1.0081 | 0.0000 | 0.0183 | 0.1759 | 1.5550 |