Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 12098.157 | uM | inf | 1.40390 | 0.3594 | 0.5068 | 4.9916 | 0.1832 | 0.8708 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 10579.139 | uM | 2.020 | 1.80530 | 0.1277 | 0.1416 | 2.9630 | 0.3124 | 0.9786 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 10579.138 | uM | inf | inf | 0.2201 | 0.2201 | 0.0000 | 0.2647 | 0.4560 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 12098.16 | uM | 13.38460 | 65.75340 | -0.2414 | -1.0000 | 0.6902 | 0.2552 | 0.8253 | 0.9575 | |
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7536.016 | uM | 1.33320 | 1.43040 | -0.3635 | -0.2106 | 5.0000 | 0.4917 | 0.8761 | 0.6413 | ||
| SUM229PE | TNBC | - | (Z)-4-Hydroxytamoxifen | ESR1 | 9860.019 | uM | 7.90460 | 30.21810 | -0.8836 | -1.0000 | 0.8193 | 0.3487 | 0.9244 | 1.6927 | ||
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 9860.037 | uM | 0.02383 | 0.13802 | -0.8181 | -0.6015 | 0.4496 | 0.7806 | 0.8992 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 7536.05 | uM | 0.03109 | 0.06441 | -0.6473 | -0.6005 | 1.0833 | 0.9322 | 0.9561 | 0.9494 | |
| SUM229PE | TNBC | - | 2-deoxyglucose | 13062.177 | uM | 1113.5250 | 980.09460 | 0.1793 | 0.1197 | 2.1446 | 0.1413 | 0.7486 | 1.7820 | |||
| SUM229PE | TNBC | - | 2-deoxyglucose | 13009.177 | uM | 737.68510 | 1000.00000 | 0.0596 | -0.1957 | 1.0856 | 0.1991 | 0.7659 | 1.2366 | |||
| SUM229PE | TNBC | - | 5-DFUR | TYMS | TYMS | 11058.143 | uM | 122.56230 | 1000.00000 | -0.1077 | -0.6589 | 0.4004 | 0.3527 | 0.9720 | 2.3374 | |
| SUM229PE | TNBC | - | 5-FU | TYMS | TYMS | 9860.017 | uM | 101.33310 | 457.99020 | -0.6201 | -0.7786 | 0.6224 | 0.5379 | 0.9953 | 1.7158 | |
| SUM229PE | TNBC | - | Afatinib | EGFR/HER2 | ErbB | 11058.158 | uM | 1.76370 | 5.52960 | -0.8088 | -1.0000 | 0.9614 | 0.4777 | 0.9540 | 2.1018 | |
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 7537.066 | uM | 26.08790 | 6.20780 | 0.4820 | 0.3992 | 1.1154 | 0.1176 | 0.9213 | 2.0549 | |
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 7535.066 | uM | 5.15860 | 4.60680 | 0.2165 | 0.2160 | 5.0000 | 0.1733 | 0.9238 | 0.7812 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 9860.019 | uM | inf | 0.66920 | 0.6943 | 0.6826 | 1.3958 | 0.1614 | 0.7691 | 1.6927 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 7536.016 | uM | 7.57380 | 8.19850 | -0.4001 | -0.2432 | 5.0000 | 0.4156 | 0.8150 | 0.6413 | |
| SUM229PE | TNBC | - | AS-252424 | PI3K | PI3K | 11058.158 | uM | inf | 1.27320 | 0.4597 | 0.6173 | 1.6385 | 0.1628 | 0.6573 | 2.1018 | |
| SUM229PE | TNBC | - | Baicalein | Lipoxygenase | Metabolism | 11058.072 | uM | inf | 999.9990 | 0.7363 | 0.5109 | 0.1359 | 0.1245 | 0.6645 | 2.3023 | |
| SUM229PE | TNBC | - | Baicalein | Lipoxygenase | Metabolism | 7535.072 | uM | 50.49310 | 39.54220 | 0.3408 | 0.3400 | 4.6606 | 0.0824 | 0.9254 | 1.0923 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7535.074 | uM | 0.75051 | 3.36660 | -0.9254 | -1.0000 | 0.7320 | 0.6555 | 0.9722 | 1.0507 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7535.074 | uM | 0.75051 | 3.36660 | -0.9254 | -1.0000 | 0.7320 | 0.6555 | 0.9722 | 1.0507 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 7537.074 | uM | 0.02770 | 0.04580 | -0.7839 | -0.7561 | 1.8316 | 1.1238 | 0.9963 | 2.0080 |