Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7534.069 | uM | 0.01858 | 1.36910 | -0.8119 | -1.0000 | 0.2555 | 0.6545 | 0.7962 | 0.8641 | |
| SUM225CWN | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7533.069 | uM | 0.00404 | 0.00166 | 0.2934 | 0.3132 | 1.1071 | 0.5248 | 0.9943 | 1.1713 | |
| SUM225CWN | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7534.084 | uM | 10.43950 | 104.81120 | -0.8432 | -1.0000 | 0.4763 | 0.4154 | 0.8179 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7533.084 | uM | 62.5130 | 235.27250 | -0.1872 | -0.6522 | 0.6299 | 0.2496 | 0.9859 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Sulindac sulfide | COX1/2 | COX | 10579.136 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0370 | -2.7510 | 0.6876 | |
| SUM225CWN | HER2amp | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7534.067 | uM | 5.05080 | 7.3920 | -0.9982 | -1.0000 | 2.8847 | 0.4927 | 0.9968 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7533.067 | uM | 7.49230 | 10.23850 | -0.9978 | -0.9990 | 3.5158 | 0.3989 | 0.9982 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 12098.159 | uM | 0.68326 | 0.91431 | -0.5733 | -0.4456 | 2.1874 | 0.3698 | 0.9871 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 10579.14 | uM | 0.89562 | 1.64720 | -0.6237 | -0.6332 | 1.3428 | 0.3766 | 0.9973 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 12098.135 | uM | 46.02120 | 26.01180 | 0.4713 | 0.4711 | 4.9981 | 0.0756 | 0.8364 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10579.135 | uM | 27.94260 | 27.10220 | 0.0711 | 0.0708 | 5.0000 | 0.0993 | 0.9788 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Temsirolimus | MTOR | MTOR | 10579.144 | uM | inf | inf | -0.9866 | -0.9866 | 0.0000 | 0.8900 | 0.5669 | 0.9576 | |
| SUM225CWN | HER2amp | Basal A | Temsirolimus | MTOR | MTOR | 12098.144 | uM | 0.05398 | 1.60770 | -0.9617 | -1.0000 | 0.3237 | 0.7616 | 0.8855 | 1.1959 | |
| SUM225CWN | HER2amp | Basal A | Torkinib | 15403.211 | uM | 0.02304 | 0.20245 | -0.6514 | -0.8008 | 0.4399 | 0.7911 | 0.9881 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12098.16 | uM | 14.87220 | 31.06620 | -0.0609 | -1.0000 | 1.4914 | 0.1300 | 0.9038 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10579.138 | uM | 17.78210 | 27.86030 | -0.9296 | -1.0000 | 2.4468 | 0.2690 | 0.9743 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | TPCA-1 | IKK | NFKB | 10579.1 | uM | 55.67060 | 355.420 | 0.2212 | -1.0000 | 0.5926 | 0.1641 | 0.7025 | 0.9677 | |
| SUM225CWN | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7533.065 | uM | 15.79290 | 30.37820 | -0.8989 | -0.9229 | 1.5987 | 0.7929 | 0.9958 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7534.065 | uM | 10.50870 | 15.19020 | -0.9528 | -0.9489 | 2.8877 | 0.8542 | 0.9991 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Triciribine | AKT | AKT | 7534.074 | uM | 0.13095 | 1.40330 | -0.2458 | -0.6053 | 0.3345 | 0.4788 | 0.9547 | 1.1026 | |
| SUM225CWN | HER2amp | Basal A | Triciribine | AKT | AKT | 7533.074 | uM | 0.12897 | 0.47437 | -0.1958 | -0.3392 | 0.3976 | 0.4636 | 0.9657 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 12098.143 | uM | 662.97740 | 1000.00000 | -0.9490 | -0.4767 | 1.6290 | 0.2498 | 0.8247 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 10579.143 | uM | 578.370 | 1000.00000 | -0.9691 | -0.5846 | 1.4142 | 0.2789 | 0.8858 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7534.065 | uM | 154.18940 | 274.48430 | -0.9415 | -0.9448 | 1.8400 | 0.6487 | 0.9875 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7533.065 | uM | 128.55160 | 280.87380 | -0.8907 | -0.9190 | 1.3346 | 0.6680 | 0.9918 | 1.0679 |