Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 11057.135 | uM | 1.28990 | 0.96672 | 0.1560 | 0.1358 | 1.0990 | 0.2860 | 0.9973 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Nelfinavir | 13054.174 | uM | inf | inf | 0.9613 | 0.9613 | 0.0000 | 0.0251 | 0.1450 | 3.1161 | |||
| SUM159PT | TNBC | Basal B | Nelfinavir | 13004.174 | uM | 9.96910 | 15.89760 | -0.7031 | -1.0000 | 2.3541 | 0.1857 | 0.9862 | 3.2757 | |||
| SUM159PT | TNBC | Basal B | Nilotinib | ABL | nRTK | 11057.145 | uM | inf | inf | 1.0062 | 1.0062 | 0.0000 | -0.0143 | -0.1841 | 3.8266 | |
| SUM159PT | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10520.14 | uM | 1.48650 | 1.72640 | -0.7051 | -0.5565 | 5.0000 | 0.5214 | 0.9692 | 3.7031 | |
| SUM159PT | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 11057.152 | uM | 2.59470 | 3.4840 | -0.7348 | -0.5153 | 2.4037 | 0.4415 | 0.9745 | 3.8541 | |
| SUM159PT | TNBC | Basal B | NU6102 | CDK1/2 | CDK | 11057.147 | uM | 17.1090 | 24.21920 | -0.1545 | -0.3781 | 1.6205 | 0.1481 | 0.9919 | 3.9818 | |
| SUM159PT | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7531.066 | uM | 28.51480 | 18.95280 | 0.4313 | 0.4300 | 4.8127 | 0.0341 | 0.9860 | 3.3129 | |
| SUM159PT | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 11057.147 | uM | 7.28880 | 6.97660 | 0.0532 | 0.0438 | 2.0939 | 0.2366 | 0.9949 | 3.9818 | |
| SUM159PT | TNBC | Basal B | Omipalisib | PI3K | PI3K | 10520.087 | uM | 0.05981 | 0.06791 | -0.1654 | -0.1232 | 1.7340 | 0.5120 | 0.9904 | 2.3483 | |
| SUM159PT | TNBC | Basal B | Omipalisib | PI3K | PI3K | 7531.086 | uM | 0.02036 | 0.02017 | -0.0133 | 0.0051 | 1.1296 | 0.5707 | 0.9982 | 3.3103 | |
| SUM159PT | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7920.075 | uM | 9.39680 | 19.30080 | -0.2022 | -0.3465 | 0.7314 | 0.3790 | 0.9828 | 4.5785 | |
| SUM159PT | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9844.021 | uM | 3.94970 | 11.04590 | -0.5941 | -0.6389 | 0.8005 | 0.4951 | 0.9919 | 2.4889 | |
| SUM159PT | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7919.011 | uM | 3.12240 | 8.27220 | -0.4592 | -0.5231 | 0.7349 | 0.5067 | 0.9950 | 3.6508 | |
| SUM159PT | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7918.011 | uM | 3.87110 | 9.76440 | -0.4701 | -0.5380 | 0.7894 | 0.5014 | 0.9983 | 2.8897 | |
| SUM159PT | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 11057.147 | uM | 0.84250 | 4.57980 | -0.7232 | -1.0000 | 0.6489 | 0.4577 | 0.9988 | 3.9818 | |
| SUM159PT | TNBC | Basal B | PD 98059 | MEK | MAPK | 11057.152 | uM | 172.25410 | 634.23160 | 0.7857 | -0.9988 | 0.8422 | 0.0305 | 0.8640 | 3.8541 | |
| SUM159PT | TNBC | Basal B | PD 98059 | MEK | MAPK | 10520.136 | uM | inf | 60.9410 | 0.7037 | 0.5045 | 0.8153 | 0.0356 | 0.8909 | 4.0331 | |
| SUM159PT | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 7531.093 | uM | 7.4930 | 12.79190 | -0.7611 | -1.0000 | 2.0541 | 0.1933 | 0.9948 | 3.5995 | |
| SUM159PT | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 10520.1 | uM | 10.6390 | 15.90380 | -0.7137 | -0.7746 | 2.3277 | 0.1919 | 0.9963 | 3.6151 | |
| SUM159PT | TNBC | Basal B | PD184352 | MEK | MAPK | 11057.155 | uM | 20.13750 | 999.99970 | 0.4189 | -0.5412 | 0.1878 | 0.2397 | 0.9353 | 4.1614 | |
| SUM159PT | TNBC | Basal B | PD184352 | MEK | MAPK | 11057.155 | uM | 20.13750 | 999.99970 | 0.4189 | -0.5412 | 0.1878 | 0.2397 | 0.9353 | 4.1614 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7531.095 | uM | inf | inf | 0.9518 | 0.9518 | 0.0000 | 0.0484 | 0.3294 | 3.5302 | |
| SUM159PT | TNBC | Basal B | PS-1145 | IKK | NFKB | 7531.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0370 | -7.5867 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7531.067 | uM | inf | 34.52310 | 0.8619 | 0.8619 | 5.0000 | 0.0137 | 0.8457 | 3.6061 |