Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | IKK16 | IKK | NFKB | 10520.1 | uM | 2.40510 | 2.88530 | -0.7137 | -0.7142 | 4.8747 | 0.4327 | 0.9970 | 3.6151 | |
| SUM159PT | TNBC | Basal B | IKK16 | IKK | NFKB | 7531.093 | uM | 1.40610 | 2.10440 | -0.7611 | -0.7731 | 2.3179 | 0.4823 | 0.9996 | 3.5995 | |
| SUM159PT | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7531.091 | uM | 16.48580 | 19.68790 | -0.7788 | -0.7146 | 5.0000 | 0.4358 | 0.9967 | 3.3140 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7531.067 | uM | 0.14051 | 1.2530 | -0.7605 | -1.0000 | 0.5021 | 0.5563 | 0.9445 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7531.095 | uM | 0.01770 | 0.35537 | -0.7677 | -1.0000 | 0.3663 | 0.7622 | 0.9140 | 3.5302 | |
| SUM159PT | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 11057.144 | uM | 14.15840 | 170.79050 | -0.1209 | -1.0000 | 0.4412 | 0.2119 | 0.8005 | 3.7784 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 10520.137 | uM | 18.60730 | 49.81870 | 0.2133 | -1.0000 | 1.1155 | 0.1476 | 0.8304 | 3.7823 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 11057.149 | uM | 29.35970 | 49.41790 | 0.4099 | -0.8250 | 1.8716 | 0.0368 | 0.9824 | 4.1019 | |
| SUM159PT | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7531.098 | uM | inf | inf | 0.9783 | 0.9783 | 0.0000 | -0.0040 | 0.0169 | 3.4793 | |
| SUM159PT | TNBC | Basal B | LBH589 | HDAC | HDAC | 11057.154 | uM | 0.24013 | 0.40952 | -0.7352 | -0.7529 | 1.7208 | 0.6122 | 0.9965 | 3.8498 | |
| SUM159PT | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10520.142 | uM | 0.60192 | 4.63920 | -0.7591 | -1.0000 | 0.5380 | 0.5173 | 0.9805 | 3.1766 | |
| SUM159PT | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11057.154 | uM | 0.93514 | 4.6160 | -0.7352 | -1.0000 | 0.6881 | 0.3694 | 0.9808 | 3.8498 | |
| SUM159PT | TNBC | Basal B | Mebendazole | 13054.174 | uM | 0.26419 | 0.20965 | 0.0726 | 0.1958 | 2.1487 | 0.3901 | 0.9341 | 3.1161 | |||
| SUM159PT | TNBC | Basal B | Mebendazole | 13004.174 | uM | 0.25791 | 0.33026 | -0.1743 | -0.1821 | 1.2558 | 0.5096 | 0.9921 | 3.2757 | |||
| SUM159PT | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7531.085 | uM | inf | inf | 0.9657 | 0.9657 | 0.0000 | 0.0219 | 0.4445 | 3.5188 | |
| SUM159PT | TNBC | Basal B | Methylglyoxal | 13054.184 | uM | 220.47610 | 301.56480 | -0.8767 | -0.7403 | 2.9008 | 0.8005 | 0.8788 | 2.8248 | |||
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14287.189 | uM | 0.06674 | 0.07631 | -0.9166 | -0.4766 | 5.0000 | 0.8754 | 0.6679 | 2.3947 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14287.189 | uM | 0.06674 | 0.07631 | -0.9166 | -0.4766 | 5.0000 | 0.8754 | 0.6679 | 2.3947 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14176.189 | uM | 0.07247 | 0.0870 | -1.0000 | -0.7475 | 5.0000 | 0.9511 | 0.8952 | 0.4285 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14176.189 | uM | 0.07247 | 0.0870 | -1.0000 | -0.7475 | 5.0000 | 0.9511 | 0.8952 | 0.4285 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11057.145 | uM | 0.05731 | 0.07460 | -0.7373 | -0.5011 | 2.6315 | 0.7726 | 0.9669 | 3.8266 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11057.145 | uM | 0.05731 | 0.07460 | -0.7373 | -0.5011 | 2.6315 | 0.7726 | 0.9669 | 3.8266 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14625.189 | uM | 0.04393 | 0.06589 | -0.8973 | -0.8783 | 2.5014 | 1.0556 | 0.9734 | 2.7202 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14625.189 | uM | 0.04393 | 0.06589 | -0.8973 | -0.8783 | 2.5014 | 1.0556 | 0.9734 | 2.7202 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 10520.135 | uM | 0.79624 | 0.86326 | -0.0471 | -0.0481 | 1.1374 | 0.3389 | 0.9955 | 3.6895 |