Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7918.012 | uM | 0.00713 | 0.00736 | -0.2575 | -0.0364 | 2.2014 | 0.7476 | 0.8332 | 2.9753 | |
| SUM159PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9844.012 | uM | 0.01103 | 0.01573 | -0.4485 | -0.4560 | 1.8263 | 0.9855 | 0.9970 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7919.04 | uM | 0.00594 | 0.00689 | -0.2375 | -0.2460 | 2.7121 | 0.9268 | 0.9992 | 3.7375 | |
| SUM159PT | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7918.011 | uM | 0.01289 | 0.01150 | 0.1062 | 0.2169 | 4.9998 | 0.5466 | 0.9295 | 2.8897 | |
| SUM159PT | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7920.075 | uM | 0.03294 | 0.03077 | 0.0327 | 0.0670 | 2.1177 | 0.7312 | 0.9949 | 4.5785 | |
| SUM159PT | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7919.011 | uM | 0.01129 | 0.00993 | 0.1791 | 0.1893 | 3.7073 | 0.6000 | 0.9981 | 3.6508 | |
| SUM159PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 10520.138 | uM | 1.87660 | 1.27670 | 0.3703 | 0.4271 | 5.0000 | 0.1293 | 0.9660 | 3.3183 | ||
| SUM159PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 11057.15 | uM | inf | 1.87160 | 0.6613 | 0.6691 | 2.5283 | 0.0649 | 0.9799 | 4.0042 | ||
| SUM159PT | TNBC | Basal B | GM6001 | MMP | MMP | 7531.096 | uM | inf | inf | 0.9199 | 0.9199 | 0.0000 | 0.0349 | 0.0835 | 3.5504 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 7920.001 | uM | 7.60870 | 32.44490 | -0.0516 | -1.0000 | 0.7575 | 0.1691 | 0.9522 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 9844.001 | uM | 2.31250 | 10.17580 | -0.5353 | -1.0000 | 0.7415 | 0.2812 | 0.9549 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 7918.001 | uM | 4.16590 | 11.8150 | -0.5556 | -1.0000 | 1.0539 | 0.2355 | 0.9785 | 2.8818 | |
| SUM159PT | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7531.098 | uM | 21.55910 | 22.93360 | 0.2842 | -0.0231 | 0.7298 | 0.1038 | 0.9237 | 3.4793 | |
| SUM159PT | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7531.091 | uM | 3.9080 | 4.71920 | -0.7888 | -0.7840 | 5.0000 | 0.4554 | 0.9983 | 3.3140 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7918.001 | uM | 0.04851 | 0.07848 | -0.6546 | -0.4004 | 1.2227 | 0.6118 | 0.9593 | 2.8818 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9844.001 | uM | 0.03485 | 0.03924 | -0.6948 | -0.4048 | 5.0000 | 0.7254 | 0.9719 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7920.001 | uM | 0.03320 | 0.02904 | 0.0820 | 0.0724 | 1.1683 | 0.5004 | 0.9949 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7918.001 | uM | 0.19174 | 3.7620 | -0.5406 | -1.0000 | 0.3691 | 0.4525 | 0.8472 | 2.8818 | |
| SUM159PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9844.001 | uM | 0.06233 | 0.07524 | -0.5777 | -0.1413 | 1.3220 | 0.4952 | 0.8861 | 2.3587 | |
| SUM159PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7920.001 | uM | 0.04495 | 0.03755 | 0.0271 | 0.2029 | 2.8919 | 0.4024 | 0.9647 | 4.4085 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 7531.088 | uM | 40.33110 | 43.51550 | 0.7440 | -0.2311 | 4.9988 | 0.0100 | 0.8340 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW843682X | PLK | PLK | 10520.139 | uM | inf | 1.59050 | 0.6546 | 0.5886 | 0.5859 | 0.1202 | 0.8212 | 3.6491 | |
| SUM159PT | TNBC | Basal B | Ibandronate | FDPS | 11057.143 | uM | 98.76930 | 55.29940 | 0.2436 | 0.2680 | 1.3241 | 0.1795 | 0.9859 | 4.1426 | ||
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10520.139 | uM | 0.37105 | 0.20739 | 0.2882 | 0.2792 | 1.4047 | 0.3216 | 0.9530 | 3.6491 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 11057.151 | uM | 1.55590 | 0.41918 | 0.3947 | 0.3852 | 1.1222 | 0.2144 | 0.9948 | 4.1698 |