Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Torkinib | 15401.211 | uM | -inf | 0.00012 | -0.9603 | -0.8964 | 0.4331 | 1.6631 | 0.9588 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10875.15 | uM | 0.60965 | 4.66480 | -0.3108 | -0.8213 | 0.4775 | 0.3610 | 0.9612 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12428.169 | uM | 3.01360 | 12.5950 | -0.8598 | -1.0000 | 0.7682 | 0.3878 | 0.9673 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 10381.093 | uM | 0.74301 | 1.23160 | -0.4026 | -0.4073 | 1.1791 | 0.4288 | 0.9942 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | Trametinib | MEK | MAPK | 7529.05 | uM | 0.05070 | 0.05677 | -0.0577 | -0.0590 | 0.9862 | 0.4749 | 0.9651 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | Trametinib | MEK | MAPK | 10139.012 | uM | 0.15977 | 0.58216 | -0.2185 | -0.3974 | 0.4523 | 0.3967 | 0.9658 | 0.8556 | |
| SUM1315MO2 | TNBC | Basal B | Trametinib | MEK | MAPK | 9797.012 | uM | 0.01756 | 0.02951 | -0.3386 | -0.2586 | 0.8029 | 0.6087 | 0.9686 | 0.4792 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7528.065 | uM | 44.86490 | 65.5740 | -0.9054 | -0.8543 | 2.6255 | 0.6553 | 0.9931 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 9044.065 | uM | 35.57120 | 53.06090 | -1.0000 | -1.0000 | 2.7472 | 0.7056 | 0.9961 | 0.5944 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 10381.065 | uM | 47.60670 | 65.64780 | -0.9168 | -0.8928 | 3.1883 | 0.6130 | 0.9986 | 1.2390 | |
| SUM1315MO2 | TNBC | Basal B | Triciribine | AKT | AKT | 9044.074 | uM | 0.12505 | 0.26132 | -0.1131 | -0.2218 | 0.4981 | 0.4707 | 0.9829 | 0.6607 | |
| SUM1315MO2 | TNBC | Basal B | Triciribine | AKT | AKT | 7528.074 | uM | 0.96910 | 2.10810 | 0.0070 | -0.2267 | 0.4811 | 0.3010 | 0.9908 | 1.0143 | |
| SUM1315MO2 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 12428.143 | uM | 902.48790 | 1000.00000 | -0.8280 | -0.3352 | 5.0000 | 0.1793 | 0.8521 | 0.7057 | |
| SUM1315MO2 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 10875.143 | uM | 744.6310 | 1000.00000 | -0.8216 | -0.4130 | 2.0418 | 0.2543 | 0.8722 | 0.8219 | |
| SUM1315MO2 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9797.006 | uM | 0.00425 | 0.00528 | -1.0000 | -0.9693 | 4.9995 | 1.7533 | 0.9968 | 0.4196 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 9044.065 | uM | 82.98250 | 261.01970 | -0.9871 | -0.9939 | 0.9551 | 0.6403 | 0.9792 | 0.5944 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7528.065 | uM | 131.72910 | 438.6910 | -0.7595 | -0.8756 | 0.8413 | 0.5743 | 0.9877 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 10381.065 | uM | 212.2460 | 499.47260 | -0.8654 | -0.9079 | 1.2097 | 0.5192 | 0.9975 | 1.2390 | |
| SUM1315MO2 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 12428.157 | uM | 1.02840 | 0.98339 | 0.2789 | 0.1002 | 5.0000 | 0.3657 | 0.8404 | 0.9842 | |
| SUM1315MO2 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 10875.151 | uM | 0.42450 | 0.64818 | -0.9033 | -0.8837 | 2.4049 | 0.7977 | 0.9990 | 0.7096 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14281.189 | uM | 0.21395 | 0.34111 | -0.9998 | -0.9158 | 2.2313 | 0.8353 | 0.9788 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12428.169 | uM | inf | inf | 0.9057 | 0.9057 | 0.0000 | 0.0256 | 0.3399 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 10875.15 | uM | inf | 0.00704 | 0.8585 | 0.8717 | 4.9959 | 0.0873 | 0.6578 | 0.8527 | |
| SUM149PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7917.016 | uM | 274.97130 | 946.23690 | 0.6414 | -1.0000 | 0.8890 | 0.0413 | 0.9052 | 2.9532 | ||
| SUM149PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9830.019 | uM | 40.41620 | 63.43880 | -0.8334 | -1.0000 | 2.4368 | 0.1575 | 0.9930 | 1.9053 |