Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 9044.067 | uM | inf | inf | -0.2355 | -0.2355 | 0.0000 | 0.4250 | 0.1569 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7528.067 | uM | 7.43620 | 8.85450 | -0.7158 | -0.6968 | 5.0000 | 0.3324 | 0.9973 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ribavirin | 15401.211 | uM | inf | inf | 0.9740 | 0.9740 | 0.0000 | 0.0925 | 0.0630 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 10875.144 | uM | 50.31320 | 314.96770 | 0.3208 | -1.0000 | 0.5990 | 0.1285 | 0.9463 | 0.7785 | |
| SUM1315MO2 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 12428.168 | uM | inf | 8.12910 | 0.6277 | 0.6256 | 1.6230 | 0.0899 | 0.9516 | 0.7957 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 10875.155 | uM | 9.6740 | 123.68830 | 0.1633 | -1.0000 | 0.4311 | 0.1704 | 0.9503 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 12428.155 | uM | 2.32320 | 2.03150 | 0.1719 | 0.0435 | 0.6790 | 0.2681 | 0.9728 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12428.165 | uM | 4.75260 | 11.16850 | -0.9976 | -1.0000 | 1.2858 | 0.3199 | 0.9814 | 0.7051 | |
| SUM1315MO2 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 10875.153 | uM | 3.45660 | 8.33320 | -0.9886 | -1.0000 | 1.2485 | 0.3668 | 0.9823 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7529.068 | uM | 0.18707 | 4.90180 | -0.9916 | -1.0000 | 0.3364 | 0.6856 | 0.7828 | 0.6347 | |
| SUM1315MO2 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 9044.069 | uM | 0.41926 | 17.95850 | -0.3686 | -1.0000 | 0.2924 | 0.4073 | 0.8103 | 0.9676 | |
| SUM1315MO2 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7528.069 | uM | inf | 0.00239 | 0.3079 | 0.5122 | 1.5226 | 0.3471 | 0.8365 | 1.0080 | |
| SUM1315MO2 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7528.084 | uM | inf | inf | -0.3471 | -0.3471 | 0.0000 | 0.3052 | 0.5102 | 1.0247 | |
| SUM1315MO2 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 9044.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4769 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 9044.067 | uM | 0.05573 | 1.21580 | -1.0000 | -1.0000 | 0.3564 | 0.8720 | 0.5906 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7528.067 | uM | 7.17140 | 9.68250 | -0.9991 | -1.0000 | 3.6595 | 0.4351 | 0.9964 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Taxol | TUBB | TUBB | 10139.002 | uM | 0.00921 | 0.01437 | -0.5588 | -0.5304 | 1.6260 | 0.9090 | 0.9971 | 0.8715 | |
| SUM1315MO2 | TNBC | Basal B | Taxol | TUBB | TUBB | 9797.002 | uM | 0.00284 | 0.00504 | -0.9455 | -0.9308 | 1.8346 | 1.3072 | 0.9984 | 0.4052 | |
| SUM1315MO2 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 12428.152 | uM | 0.43095 | 0.99878 | -0.9474 | -1.0000 | 1.3070 | 0.5725 | 0.9940 | 0.8719 | |
| SUM1315MO2 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 10875.152 | uM | 0.19758 | 0.40176 | -0.9810 | -0.9895 | 1.5381 | 0.6828 | 0.9980 | 0.7465 | |
| SUM1315MO2 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 10875.148 | uM | inf | inf | 0.1492 | 0.1492 | 0.0000 | 0.2658 | 0.4170 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 12428.135 | uM | 23.67060 | 153.34310 | 0.0267 | -1.0000 | 0.5880 | 0.2087 | 0.9114 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 10875.144 | uM | 0.08860 | 2.28190 | -0.9975 | -1.0000 | 0.3382 | 0.7166 | 0.8682 | 0.7785 | |
| SUM1315MO2 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 12428.168 | uM | 0.55196 | 0.92365 | -0.0587 | -0.1034 | 0.3652 | 0.4485 | 0.8852 | 0.7957 | |
| SUM1315MO2 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7529.078 | uM | 0.00722 | 0.12095 | -0.8881 | -1.0000 | 0.3897 | 1.0523 | 0.9791 | 0.7619 |