Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | NU6102 | CDK1/2 | CDK | 10875.147 | uM | 2.25980 | 7.82550 | -0.9660 | -1.0000 | 0.8845 | 0.3574 | 0.9621 | 0.7554 | |
| SUM1315MO2 | TNBC | Basal B | NU6102 | CDK1/2 | CDK | 12428.147 | uM | 4.31060 | 10.71710 | -0.9508 | -1.0000 | 1.2063 | 0.3108 | 0.9859 | 0.6926 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 9044.066 | uM | 17.21680 | 31.40520 | -0.6165 | -1.0000 | 1.8277 | 0.1712 | 0.9561 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7528.066 | uM | 22.50560 | 44.30250 | -0.3231 | -1.0000 | 1.6221 | 0.1520 | 0.9703 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 10381.066 | uM | 16.81440 | 37.95530 | -0.3782 | -1.0000 | 1.3494 | 0.1873 | 0.9744 | 1.4484 | |
| SUM1315MO2 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 12428.147 | uM | 3.62890 | 6.03330 | -0.9670 | -0.9998 | 2.1608 | 0.4834 | 0.9971 | 0.6926 | |
| SUM1315MO2 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 10875.147 | uM | 3.34440 | 5.18440 | -0.9484 | -0.9640 | 2.4506 | 0.4788 | 0.9986 | 0.7554 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 10381.087 | uM | 0.00950 | 0.05569 | -0.6720 | -0.6295 | 0.4608 | 0.7970 | 0.9747 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10139.021 | uM | 11.52390 | 26.06550 | -0.9909 | -1.0000 | 1.3460 | 0.5022 | 0.9904 | 0.8389 | |
| SUM1315MO2 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9797.011 | uM | 14.70390 | 27.26290 | -0.9996 | -1.0000 | 1.7794 | 0.5022 | 0.9904 | 0.5004 | |
| SUM1315MO2 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 10875.147 | uM | 2.05390 | 2.55590 | -0.9932 | -0.9923 | 5.0000 | 0.5106 | 0.9974 | 0.7554 | |
| SUM1315MO2 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 12428.147 | uM | 2.12860 | 2.64750 | -0.9931 | -0.9882 | 5.0000 | 0.4864 | 0.9989 | 0.6926 | |
| SUM1315MO2 | TNBC | Basal B | PD 98059 | MEK | MAPK | 12428.152 | uM | inf | inf | 0.6663 | 0.6663 | 0.0000 | 0.0645 | 0.5698 | 0.8719 | |
| SUM1315MO2 | TNBC | Basal B | PD 98059 | MEK | MAPK | 10875.152 | uM | inf | 1.40660 | 0.6669 | 0.5616 | 0.2100 | 0.1593 | 0.5998 | 0.7465 | |
| SUM1315MO2 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 10381.093 | uM | 3.27850 | 4.8590 | -0.6231 | -0.6510 | 2.1192 | 0.2588 | 0.9925 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | PD184352 | MEK | MAPK | 10875.155 | uM | inf | 0.06510 | 0.8182 | 0.8795 | 4.9994 | 0.0502 | 0.6963 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | PD184352 | MEK | MAPK | 10875.155 | uM | inf | 0.06510 | 0.8182 | 0.8795 | 4.9994 | 0.0502 | 0.6963 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | PD184352 | MEK | MAPK | 12428.155 | uM | 17.66090 | 82.23440 | 0.3075 | -1.0000 | 0.7142 | 0.1086 | 0.9658 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | PD184352 | MEK | MAPK | 12428.155 | uM | 17.66090 | 82.23440 | 0.3075 | -1.0000 | 0.7142 | 0.1086 | 0.9658 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10381.095 | uM | inf | inf | 0.9036 | 0.9036 | 0.0000 | 0.0459 | 0.3358 | 1.2787 | |
| SUM1315MO2 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 9044.095 | uM | inf | inf | 0.8681 | 0.8681 | 0.0000 | 0.1009 | 0.5260 | 0.7214 | |
| SUM1315MO2 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7528.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.8526 | |
| SUM1315MO2 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7528.065 | uM | inf | inf | 0.9471 | 0.9471 | 0.0000 | 0.0539 | 0.1818 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | PS-1145 | IKK | NFKB | 9044.065 | uM | inf | inf | 0.8636 | 0.8636 | 0.0000 | -0.0127 | 0.3821 | 0.5944 | |
| SUM1315MO2 | TNBC | Basal B | PS-1145 | IKK | NFKB | 10381.065 | uM | inf | inf | 0.8948 | 0.8948 | 0.0000 | -0.0084 | 0.4505 | 1.2390 |