Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 7527.085 | uM | 0.25295 | 0.74429 | -0.8676 | -0.9482 | 0.9854 | 0.5732 | 0.9922 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 11851.161 | uM | 193.66530 | 920.44020 | 0.6484 | -0.9970 | 0.7035 | 0.0634 | 0.8163 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 11851.154 | uM | inf | inf | 0.9971 | 0.9971 | 0.0000 | 0.0156 | 0.0000 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9760.024 | uM | 2.94480 | 7.12650 | -0.6444 | -0.9147 | 1.1769 | 0.3582 | 0.7498 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7912.016 | uM | 0.12456 | 1.17340 | -0.7859 | -1.0000 | 0.4898 | 0.6417 | 0.8875 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7914.016 | uM | 5.1710 | 21.78670 | -0.1829 | -1.0000 | 0.7639 | 0.2318 | 0.9521 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 10127.049 | uM | 2.48560 | 4.22630 | -0.9279 | -0.9578 | 2.0160 | 0.3667 | 0.9657 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9759.019 | uM | 2.73010 | 5.45130 | -0.2468 | -0.4718 | 0.9610 | 0.2580 | 0.9868 | 1.3677 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10127.049 | uM | 0.03776 | 0.03383 | 0.3881 | 0.1905 | 4.3680 | 0.5207 | 0.7710 | 0.6294 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9759.012 | uM | 0.0130 | 0.01442 | -0.1909 | -0.0740 | 1.3326 | 0.7299 | 0.9855 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9760.024 | uM | 0.01422 | 0.01563 | -0.2070 | -0.1050 | 2.0137 | 0.7455 | 0.9918 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9760.131 | uM | inf | inf | 0.0731 | 0.0731 | 0.0000 | 0.6949 | 0.2538 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 10127.12 | uM | 0.00992 | 0.01206 | -0.2912 | -0.1834 | 1.5995 | 0.8220 | 0.8715 | 0.5076 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9760.011 | uM | 0.01177 | 0.01091 | 0.1988 | 0.1580 | 5.0000 | 0.6040 | 0.9817 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9759.011 | uM | 0.01008 | 0.01118 | -0.4098 | -0.3361 | 5.0000 | 0.9634 | 0.9873 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 11851.16 | uM | 48.29610 | 344.4820 | 0.4174 | -1.0000 | 0.5592 | 0.1148 | 0.9623 | 1.1668 | ||
| SK-BR-3 | HER2amp | Luminal | GM6001 | MMP | MMP | 7527.096 | uM | inf | inf | 0.9212 | 0.9212 | 0.0000 | 0.0674 | -0.2316 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10127.001 | uM | 4.71990 | 6.16470 | -0.5137 | -0.5295 | 2.7045 | 0.2236 | 0.9752 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9759.001 | uM | 8.13140 | 8.17820 | -0.0136 | -0.0145 | 4.9937 | 0.0854 | 0.9779 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9760.001 | uM | 5.06510 | 7.71320 | -0.4467 | -0.5547 | 1.7748 | 0.1880 | 0.9905 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7526.071 | uM | inf | inf | -0.0013 | -0.0013 | 0.0000 | 0.0814 | 0.4134 | 1.2290 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7526.098 | uM | inf | inf | 0.7747 | 0.7747 | 0.0000 | 0.0610 | 0.4157 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7526.091 | uM | inf | inf | -0.7665 | -0.7665 | 0.0000 | 0.3103 | 0.5701 | 1.6709 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7527.098 | uM | 3.48470 | 5.25680 | -0.8083 | -0.8162 | 2.3541 | 0.3671 | 0.9967 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7527.092 | uM | 4.77030 | 6.38960 | -0.5593 | -0.5636 | 2.5825 | 0.2999 | 0.9979 | 2.0383 |